Enzyme-Triggered Nanomaterials and Their Applications

Kumar, Vikash; Koyasseril-Yehiya, Thameez M.; Thayumanavan, S.

doi:10.1021/bk-2020-1355.ch007

Cited by 6 publications

(4 citation statements)

References 86 publications

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“…71,72 As enzymatic reactions are highly substrate specific as well as regio-and stereo-specific in nature, they are widely used for constructing various functional materials. [73][74][75] Among various functional materials, supramolecular hydrogels are promising for biological applications. Enzyme-triggered assembly of small molecules provides a facile approach to study the properties of the assembled structures in a cellular environment which is important for exploring the possibilities of supramolecular gels in biomedical research.…”

Section: (Ii) Enzymatic Reactionmentioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

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Section: (Ii) Enzymatic Reactionmentioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

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“…DPPC (1,2-dipalmitoyl-snglycero-3-phosphocholine), 1,2-distearyl-sn-glycero-3-phosphoethanolamine (DSPE), distearoylphosphatidylglycerol (DSPG), 1,2-distearyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, DSPE-PEG2000, 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) have been already utilized to prepare the desired enzyme responsive liposomes by mixing them in a appropriate ratio [13,[143][144][145]. Enzymes generally cleaves the phospholipid bond by hydrolysis producing fatty acid and lysophospholipids [146,147]. These enzyme responsive liposomes are applied for various purposes including intracellular, extracellular, targeted drug delivery, diagnostic imaging, etc.…”

Section: Types Of Liposomesmentioning

confidence: 99%

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

Adhikari

2023

ajc

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Liposomes have been thoroughly investigated and are utilized for various illnesses for the past few decades starting from its first discovery in 1961. Since then, therapeutic efficiency of liposomes is enhanced by increasing drug absorbance while fast deterioration and adverse effects are avoided or minimized. This will extend the biological halfway life. Liposomes are more attractive for usage as drug delivery carriers with all of these characteristics and versatility to modify their surface to create additional specific functionalities. In various phases of research, there are numerous new liposomal compositions that improve the therapeutic efficiency of new and old medicines used in pre-clinical and clinical studies. Current multimodal imaging advances aimed at better diagnosing and monitoring liposome therapies as diagnostic tools. Liposomes are major possibilities for medication delivery improvement. Recent researches show that the liposomes can be taken widely in cancer treatments. The primary properties of these structures include minimal toxicity, cytocompatibility, reduced clearance rates, tissue targeting and sustained drug release. Liposomes offer a variety of benefits as shown by approval of Doxil, as compared to traditional chemotherapy with free medication treatment. There are a multitude of liposomes depending on their size, lamellar number, shape and composition. Diagnostic, therapeutic, improved vaccination are covered by clinical use of these systems. Drug and gene delivery are two therapeutic aspects, where due to their unique characteristics liposomes might be beneficial. Several illnesses have been examined with respect to the participation of liposomes, with some good results. Cancer is a life-threatening disease. These structures have been examined in this respect, both in imaging and in chemotherapy. These investigations have resulted in different liposome compositions in different clinical stages. We take this great opportunity to present various surface functionalization strategies and bio-applications of liposomes developed during the last two decades covering the notable work published from 2011 to 2021 in this review. In addition, we provide opinions on the liposome industry, its commercial market and the prospective developments in the field of liposome technology. It is anticipated that this review will serve as a valuable resource, fostering interest and engagement among scientists worldwide in the field of liposome research.

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“…Different cancerous cells upregulate the expression of certain enzymes on their surface such as metalloproteinase and cathepsins. This phenomenon requires future studies to help researchers develop novel targeting agents according to those upregulated enzymes [261]. Along this line, Zhu and co-workers [27] used co-acervation technology to prepare a magnetic nanoparticle by gelatin and sodium alga acid.…”

Section: Enzyme Triggeredmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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Enzyme-Triggered Nanomaterials and Their Applications

Cited by 6 publications

References 86 publications

Stimuli responsive dynamic transformations in supramolecular gels

Stimuli responsive dynamic transformations in supramolecular gels

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

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