Enzyme responsive drug delivery systems in cancer treatment

Shahriari, Mahsa; Zahiri, Mahsa; Abnous, Khalil; Taghdisi, Seyed Mohammad; Alibolandi, Mona

doi:10.1016/j.jconrel.2019.07.004

Cited by 262 publications

(127 citation statements)

References 86 publications

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“…96 Another strategy to increase the degree of smartness from inert to active of biomaterial-based drug delivery systems entails changing the mode of chemical delivery. In active delivery, the drug release is triggered by environmental stimuli such as temperature, 97 pH change, 98 chemical and redox reactions, 99 and enzymes, 100 or by external stimuli such as electric or magnetic field, light, etc. Active drug delivery relies on the drug diffusing through the carrier matrix to reach the surrounding medium.…”

Section: Applications Of Smart Biomaterials Responding To Internal Mamentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages. Traditionally, smart biomaterials have been thought as those that respond to stimuli. However, the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials. This review presents a redefinition of the term “Smart Biomaterial” and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration. To clarify the use of the term “smart biomaterials”, we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit, defining these materials as inert, active, responsive, and autonomous. Then, we present an up-to-date survey of applications of smart biomaterials for hard tissues, based on the materials’ responses (external and internal stimuli) and their use as immune-modulatory biomaterials. Finally, we discuss the limitations and obstacles to the translation from basic research (bench) to clinical utilization that is required for the development of clinically relevant applications of these technologies.

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Section: Applications Of Smart Biomaterials Responding To Internal Mamentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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“…Overexpressed enzymes under diseased conditions have long been employed as biological signals for the design and engineering of different bioresponsive materials [ [256] , [257] , [258] ]. The responsive mechanisms mainly involve the reduction/oxidation of substrates and the formation/cleavage of chemical bonds in the presence of enzymes.…”

Section: Materials and Delivery Vehicles Responsive To Inflammatory Smentioning

confidence: 99%

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Ding

et al. 2020

Journal of Controlled Release

121

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Inflammation is intimately related to the pathogenesis of numerous acute and chronic diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative diseases. Therefore anti-inflammatory therapy is a very promising strategy for the prevention and treatment of these inflammatory diseases. To overcome the shortcomings of existing anti-inflammatory agents and their traditional formulations, such as nonspecific tissue distribution and uncontrolled drug release, bioresponsive drug delivery systems have received much attention in recent years. In this review, we first provide a brief introduction of the pathogenesis of inflammation, with an emphasis on representative inflammatory cells and mediators in inflammatory microenvironments that serve as pathological fundamentals for rational design of bioresponsive carriers. Then we discuss different materials and delivery systems responsive to inflammation-associated biochemical signals, such as pH, reactive oxygen species, and specific enzymes. Also, applications of various bioresponsive drug delivery systems in the treatment of typical acute and chronic inflammatory diseases are described. Finally, crucial challenges in the future development and clinical translation of bioresponsive anti-inflammatory drug delivery systems are highlighted.

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“…In addition to the environmental stimuli such as pH and oxidative stress, enzymes that present within the cellular system can also be utilized as a trigger for targeted drug release [127]. Nanocarriers such as polymeric micelles, liposomes, and dendrimers are often functionalized by attaching cleavable peptides to the surface that are tailored to specific enzymes present in the targeting tissues [128][129][130][131]. In order to achieve the goal of targeted cargo delivery, several releasing mechanisms can be employed.…”

Section: Enzyme-responsive Nanocarriersmentioning

confidence: 99%

“…While significant progress has been made in the development of enzyme-responsive nanocarriers, several challenges remain to be addressed for the wider application of this approach. For example, there are various enzyme subtypes existing in the biological system that share similar cleavage sites [130]. In addition, current imaging technologies are yet to satisfy the need for the confirmation of controlled drug release at the targeted areas [130].…”

Section: Enzyme-responsive Nanocarriersmentioning

confidence: 99%

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Kang

2020

Pharmaceutics

129

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Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

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Enzyme responsive drug delivery systems in cancer treatment

Cited by 262 publications

References 86 publications

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

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