Enzyme Models. I. The Preparation of some Artificial Carboxylases

Designed evolution of artificial metalloenzymes: protein catalysts made to order

“…Indeed, by the 1950s, the synergism of homogeneous catalysis and enzyme chemistry was demonstrated in the first use of "model substances having enzymelike activity" to investigate the mode of action of natural enzymes. 3 Our increased understanding of chemical and enzymatic catalysis over the last 100 years, especially since the advent of genetic engineering and recombinant technology, has led the scientific community to attempt the development of new enzymes and catalysts with modified activities, specificities and activities.…”