Enzyme-Mediated Preparation of Flavonoid Esters and Their Applications

Viskupičová, Jana; Ondrejovič, Miroslav; Maliar, Tibor

doi:10.5772/34174

Cited by 13 publications

(13 citation statements)

References 122 publications

(224 reference statements)

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“…Biotransformations performed by microorganisms consist of very complex mechanisms, including cyclization reactions, condensation, dehydroxylation, hydroxylation, O-dealkylation, alkylation, dehydrogenation, halogenation, double-bond reduction, carbonyl reduction, glycosylation, sulfation, dimerization, or various types of ring degradation. They were described earlier [132,180,181].…”

Section: Prenyltransferase (Novq)mentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and beverages such as wine and beer. Over 7000 flavonoids have been identified and they have been considered substances with a beneficial action on human health, particularly of multiple positive effects because of their antioxidant and free radical scavenging action. Although several studies indicate that some flavonoids have provident actions, they occur only at high doses, confirming in most investigations the existence of anti-inflammatory effects, antiviral or anti-allergic, and their protective role against cardiovascular disease, cancer, and various pathologies. Flavonoids are generally removed by chemical methods using solvents and traditional processes, which besides being expensive, involve long periods of time and affect the bioactivity of such compounds. Recently, efforts to develop biotechnological strategies to reduce or eliminate the use of toxic solvents have been reported, reducing processing time and maintaining the bioactivity of the compounds. In this paper, we review, analyze, and discuss methodologies for biotechnological recovery/extraction of flavonoids from agro-industrial residues, describing the advances and challenges in the topic.

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Section: Prenyltransferase (Novq)mentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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“…To date, the most frequently used solvents in flavonoid acylation reactions are 2-methyl-2-butanol [7,10,[38][39][40][41][42] and acetone [7,8,14,20,41,[43][44][45][46][47][48]. These solvents present low toxicity, and their polarity permits the proper solubilization of the substrates, leading to high conversion rates [49]. Other organic solvents commonly employed are 2-methylpropan-2-ol, hexane, and acetonitrile [50].…”

Section: Factors That Influence the Flavonoid Acylation Reactionsmentioning

confidence: 99%

“…The water content required for the catalytic process depends on the type and form of the enzyme (native or immobilized) and on the solvent [58,59]. In general, the optimal water content for esterification reactions in organic solvents ranges from 0.2 to 3.0 % [49,60]. High enzymatic activities for CALB may be achieved when the water content is about 200 ppm [10].…”

Section: Factors That Influence the Flavonoid Acylation Reactionsmentioning

confidence: 99%

Biocatalytic Synthesis of Flavonoid Esters by Lipases and Their Biological Benefits

et al. 2016

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“…24 Flavonoids in the form of aglycones are known to be more efficiently transferred into the bloodstream from the intestinal tract and more effectively act as bioactive molecules than the avonol glycosides from which they are produced. [25][26][27] Glucose is the most common sugar moiety of avonol glycosides in plants, and the b-glucosidic bonds of Q3G and IR3G are possibly deconjugated via b-glucosidase catalysis. 24,[28][29][30][31] This catalysis would produce quercetin and isorhamnetin ( Fig.…”

Section: Introductionmentioning

confidence: 99%