Enzyme-linked immunosorbent assay (ELISA) for human tumor necrosis factor (hTNF)

Abe, Yasuhito; Miyake, Masaru; Sagawa, Teiri; Kimura, Shigeru

doi:10.1016/0009-8981(88)90210-0

Cited by 18 publications

(6 citation statements)

References 6 publications

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“…Though not as frequently as anti-IL-la autoantibody, we found an anti-TNF autoantibody in the sera from patients with inflammation and in that from healthy individuals (unpublished data) when establishing an ELISA for TNF (Abe et al 1988). The establishment of monoclonal anti-TNF IgMs from a CMVpositive donor supports the existence of an anti-TNF autoantibody in natural immunoglobulin (Boyle et al 1993a(Boyle et al , 1993b.…”

Section: Other Autoantibodiesmentioning

confidence: 62%

Anti‐Cytokine Nature of Natural Human Immunoglobulin: One Possible Mechanism of the Clinical Effect of Intravenous Immunoglobulin Therapy

Abe

Horiuchi

Miyake

et al. 1994

Immunological Reviews

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151

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Section: Other Autoantibodiesmentioning

confidence: 62%

Anti‐Cytokine Nature of Natural Human Immunoglobulin: One Possible Mechanism of the Clinical Effect of Intravenous Immunoglobulin Therapy

Abe

Horiuchi

Miyake

et al. 1994

Immunological Reviews

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151

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“…Although Abs to TNF-␣ have been demonstrated in the sera of healthy individuals, 9,26 IVIg does not contain high-affinity Abs against TNF-␣. 8,17 Among the TNF-family members only one had been shown to have reactivity with IVIg.…”

Section: Tnf Family Members and Ivigmentioning

confidence: 91%

“…Although Abs to TNF‐α have been demonstrated in the sera of healthy individuals, 9,26 IVIg does not contain high‐affinity Abs against TNF‐α 8,17 …”

Section: Tnf Family Members and Ivigmentioning

confidence: 99%

Intravenous Immunoglobulin and Cytokines

Pottier¹,

Sapir

Bendaoud³

et al. 2007

Annals of the New York Academy of Sciences

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The presence of natural autoantibodies against cytokines has been reported in healthy individuals. Because circulating cytokines may be implicated in the clinical outcome of numerous diseases, the mode of action of intravenous immunoglobulin (IVIg) (pooled from sera over a thousand normal individuals) may involve immunomodulation of the cytokine network. We review the anti-cytokine effects of IVIg as well as the consequences of IVIg infusions on cytokine production. Furthermore, IVIg exerts therapeutic effects in autoimmune diseases and lymphoid malignancies. These two conditions have in common an overproduction of BAFF (for B-cell-activating factor of the TNF family). The presence of antibodies with BAFF and APRIL (a proliferation-inducing ligand) specificity was investigated. We found that IVIg recognizes BAFF and APRIL and that IVIg binding prevents BAFF from exerting its antiapoptotic effect on B cells. These anti-BAFF IgGs might prevent the deleterious effects of BAFF in B-cell-mediated autoimmune diseases.

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“…28 IVIg contains antibodies to a range of immunoregulatory molecules Antibodies to interleukin-1a (IL-1a) and tumour necrosis factor-a (TNF-a) have been demonstrated in the sera of healthy individuals. 29,30 Anti-IL-8 antibodies have been reported in connective tissue disorders and in normal volunteers. 31 Since IVIg is derived from human donors, anti-cytokine antibodies may also be present within IVIg preparations.…”

Section: Ivig Contains Anti-idiotypesmentioning

confidence: 99%

“…No effect was noted for TNF-a, 38 however, some studies have shown a dose-dependent reduction in TNF-a by IVIg, which is most pronounced for Fc fragments. 29,30 IVIg selectively increases gene transcription and secretion of IL-1 receptor antagonist (IL-1Ra) and IL-8. 39 Assessment of intracellular cytokine production by mitogenstimulated PBMCs in the presence of IVIg showed no change in IL-2, IL-10, TNF-a and IFN-g, and a reduction in IL-3, IL-4, IL-5, TNF-b and granulocyte±macrophage colony-stimulating factor producing cells.…”

Section: Effects On Cytokine Levelsmentioning

confidence: 99%