Enzyme-instructed self-assembly of peptide-drug conjugates in tear fluids for ocular drug delivery

Hu, Yuhan; Wang, Yuan; Deng, Jie; Ding, Xiangyu; Lin, Deqing; Shi, Hui; Chen, Lin; Lin, Dan; Vakal, Serhii; Wang, Jiaqing; Li, Xingyi

doi:10.1016/j.jconrel.2022.03.011

Cited by 22 publications

(13 citation statements)

References 54 publications

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“…Researchers have found that ALP expression in the tear fluid of patients with uveitis was much higher than those without uveitis. ALP-instructed self-assembly of SAPs in tear fluids offers a powerful strategy for the targeted and long-term accumulation of a therapeutic agent at the lesion site. , …”

Section: Smart Saps For Therapymentioning

confidence: 99%

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Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Zhou

et al. 2023

ACS Nano

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Self-assembly has emerged as an extensively used method for constructing biomaterials with sizes ranging from nanometers to micrometers. Peptides have been extensively investigated for self-assembly. They are widely applied owing to their desirable biocompatibility, biodegradability, and tunable architecture. The development of peptide-based nanoparticles often requires complex synthetic processes involving chemical modification and supramolecular self-assembly. Stimuli-responsive peptide nanoparticles, also termed "smart" nanoparticles, capable of conformational and chemical changes in response to stimuli, have emerged as a class of promising materials. These smart nanoparticles find a diverse range of biomedical applications, including drug delivery, diagnostics, and biosensors. Stimuli-responsive systems include external stimuli (such as light, temperature, ultrasound, and magnetic fields) and internal stimuli (such as pH, redox environment, salt concentration, and biomarkers), facilitating the generation of a library of self-assembled biomaterials for biomedical imaging and therapy. Thus, in this review, we mainly focus on peptide-based nanoparticles built by self-assembly strategy and systematically discuss their mechanisms in response to various stimuli. Furthermore, we summarize the diverse range of biomedical applications of peptide-based nanomaterials, including diagnosis and therapy, to demonstrate their potential for medical translation.

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Section: Smart Saps For Therapymentioning

confidence: 99%

“…ALP-instructed self-assembly of SAPs in tear fluids offers a powerful strategy for the targeted and long-term accumulation of a therapeutic agent at the lesion site. 162,163…”

Section: Smart Saps For Therapymentioning

confidence: 99%

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Zhou

et al. 2023

ACS Nano

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Section: Disease Treatmentsmentioning

confidence: 99%

“…In addition to the above-mentioned anticancer, antibacterial, and antiinflammation applications, IEISAP can also be applied in the delivery of ocular [ 31 ] and cardiovascular [ 122 ] drugs. Hu et al implemented the IEISAP strategy for ocular drug delivery [ 31 ]. The nonsteroidal antiinflammatory drug ibuprofen (IBF) was covalently linked with a self-assembling peptide GFFpY via a hydrolyzable ester bond to generate a phosphorylated peptide-drug precursor (IBF-HYD-GFFpY).…”

Section: Disease Treatmentsmentioning

confidence: 99%

“…For instance, the most frequently used enzyme for intracellular enzyme-instructed self-assembly of peptides (IEISAP) is ALP. ALP is overexpressed on the cell membranes of tumor cells, such as Saos-2, HeLa, Hep G2, and MESSA/Dx5 [ 24 , 25 , 26 , 27 ], bacteria [ 28 , 29 , 30 ], and tear fluid [ 31 ]. ALP dephosphorylates the peptide-derived precursors, generating more hydrophobic products for peptide assembly/aggregation and realizing in situ self-assembly of peptides into supramolecular nanostructures in living systems.…”

Section: Introductionmentioning

confidence: 99%

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Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications

Lin

Chen

2022

Molecules

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Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation imaging, and multimodal imaging, which are successfully leveraged in visualizing cancer tissues and cells, bacteria, and enzyme activity. We also summarize the utilization of IEISAP in disease treatments, including anticancer, antibacterial, and antiinflammation applications, among others. We present the design, action modes, structures, properties, functions, and performance of IEISAP materials, such as nanofibers, nanoparticles, nanoaggregates, and hydrogels. Finally, we conclude with an outlook towards future developments of IEISAP materials for biomedical applications. It is believed that this review may foster the future development of IEISAP with better performance in the biomedical field.

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Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

Wang,

Luo,

Wang

et al. 2024

Adv Funct Materials

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Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, the reported PST have shown excellent application prospects in combating many major diseases including cancer, cardiovascular disease, infectious disease, autoimmune disease, metabolic disease, and so on. Through thoughtful design, the PST can be fabricated in various forms, including self‐assembled precursor molecules, functional nano‐assemblies, and macroscopic large‐scale hydrogels. The involved peptides in the PST can play different roles, such as serving drug carriers for effective delivery, acting as scaffold materials for cell culture, and functioning as bioactive sequences for treating diseases. In this review, a comprehensive overview of traditional strategies is provided to build PST and emphasize their therapeutic applications for fighting major diseases that pose a threat to human life and health. Moreover, the main challenges of PST in systems design, therapeutic application, and clinical translation are also briefly discussed. It is hoped that this review can arouse much more attention to be paid for PST and promote its practical application in the biomedical field.

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Enzyme-instructed self-assembly of peptide-drug conjugates in tear fluids for ocular drug delivery

Cited by 22 publications

References 54 publications

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications

Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

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