Enzyme-instructed self-assembly leads to the activation of optical properties for selective fluorescence detection and photodynamic ablation of cancer cells

Ji, Shenglu; Hong, Gao; Mu, Wancen; Ni, Xiang; Yi, Xiaoyong; Shen, Jing; Liu, Qian; Bao, Pingping

doi:10.1039/c7tb02685d

Cited by 52 publications

(36 citation statements)

References 53 publications

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“…6a ). 58 The probe is a combination of TPE-Py as the AIE photosensitizer and a short peptide modified with three tyrosine phosphates as the reaction site. Benefiting from tyrosine phosphates, the AIE probe showed very weak fluorescence and low ROS generation ability.…”

Section: Aie Light-up Probes For Antitumor Applicationsmentioning

confidence: 99%

Recent advances of AIE light-up probes for photodynamic therapy

et al. 2021

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Section: Aie Light-up Probes For Antitumor Applicationsmentioning

confidence: 99%

Recent advances of AIE light-up probes for photodynamic therapy

et al. 2021

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“…have designed a theranostic probe (TPE‐Py‐FpYGpYGpY) to achieve sensitive fluorescent diagnosis and on‐demand PDT, which was composed of an AIE molecule TPE‐Py and a peptide sequence containing three pY. [ 103 ] Owing to the modification of phosphotyrosine residues, TPE‐Py‐FpYGpYGpY exhibited great aqueous solubility, thus leading to nonfluorescence and weak ROS generation ability in physiological environments. After ALP enzymatic dephosphorylation, the loss of hydrophilic phosphates in probe would result in the self‐assembly of probe and impede the rotation of phenyl rings, which would demonstrate extensive emission of fluorescence and efficient production of ROS.…”

Section: Pdt‐based Theranostic Systemsmentioning

confidence: 99%

Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

et al. 2021

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Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite the great developments, their clinical application is still in the nascent stage, owing to the unsatisfied imaging quality and limited therapeutic efficacy. Fortunately, the emerging of aggregation‐induced emission (AIE) molecules with unique fluorescence property offers an opportunity to solve the imaging problem. Besides, further utilizing the tumor microenvironments and external triggers to design the stimuli‐responsive imaging‐guided therapy could enhance the therapeutic efficacy and reduce the side effects. In this review, the advancements in stimuli‐responsive theranostic systems with AIE characteristics are summarized. Theranostic systems are first classified according to their treatment modes, and then subdivided based on various stimuli, including pH, redox, enzyme, and light. In each section, the design strategies and application examples are introduced. At last, the current state of the art, limitations, as well as prospects are also discussed.

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“…Recently, Ding et al constructed a fluorescence and photoactivity dual activatable probe (TPE-Py-FpYGpYGpY) for selective imaging and photodynamic ablation of ALPoverexpressed cancer cells. [111] The tyrosine phosphates (pY) in the tripeptide of the probe could be dephosphorylated by ALP and the hydrophobic catalytic products could self-assemble into nanostructures, leading to remarkable activation of both fluorescence and ROS generation ability. TPE-Py-FpYGpYGpY could selectively target ALP-overexpressed cancer cells (Saos-2) and exert efficient cancer cell ablation under white light irradiation via a diagnosis and therapy dual turn-on manner.…”

Section: Self-aggregation Responding To Enzymementioning

confidence: 99%

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

et al. 2020

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Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine. By virtue of the good biocompatibility, outstanding fluorescence property, easy processability and functionalization, promoted photosensitizing efficiency, as well as facile construction of multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics. Numerous significant breakthroughs and state‐of‐the‐art progression have been witnessed in the past few years. This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostics based on the experimental measurements and theoretical simulations. Additionally, the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE‐active theranostics through triggering aggregation formation are comprehensively summarized. Moreover, a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented.

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Enzyme-instructed self-assembly leads to the activation of optical properties for selective fluorescence detection and photodynamic ablation of cancer cells

Abstract: An aggregation-induced emission luminogen (AIEgen)-based probe with both fluorescence and photoactivity activatable characteristics is developed for cancer theranostics.

Cited by 52 publications

References 53 publications

Recent advances of AIE light-up probes for photodynamic therapy

Recent advances of AIE light-up probes for photodynamic therapy

Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

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