Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

Hu, Jingjing; Jiang, Wenlian; Liang, Yuan; Duan, Chong; Yuan, Qiming; Long, Zi; Lou, Xiaoding; Xia, Fan

doi:10.1002/agt2.10

Cited by 143 publications

(56 citation statements)

References 138 publications

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“…RDP demonstrated the maximum absorption peak at 405 nm, which was ascribed to the PyTPE (Figure 1E and Figure S17, Supporting Information). Both PyTPE and RDP showed aggregation‐induced emission (AIE) characteristics [ 36–43 ] when the volume ratio of DMSO/H 2 O solution changed, where DMSO served as the good solvent and H 2 O as the poor solvent (Figure 1F, Figures S18 and S19, Supporting Information). After being conjugated to the hydrophilic peptides, RDP exhibited a reduced but more stable photoluminescence (PL) intensity compared to PyTPE, indicating better hydrophilicity and photostability (Figures S20 and S21, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug

Yuan

Dong

et al. 2021

Advanced Optical Materials

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Highly effective transporting and real‐time monitoring of the drug delivery system (DDS) has attracted much attention from researchers. However, separately tracking the multiple components in a complex DDS as well as its delivery process is challengeable. Here, a multi‐fluorescence‐labeled ternary complex is designed for delivering the therapeutic agents and monitoring the multiple components. Ternary complex (A@TR) is formed by three parts, including a) the carrier module TFD, which is a cell‐penetrating peptide (TAT) conjugated with anti‐cancer drug doxorubicin (DOX) and fluorescent molecule fluorescein isothiocyanate (FITC); b) therapeutic genes (ASO); c) the targeting module RDP based on a cyclic RGDFK peptide and aggregation‐induced‐emission luminogen PyTPE. The labeling of FITC through the covalent bond can stably track the location of anticancer drugs and genes in the long term. Meanwhile, the mark of PyTPE can monitor the process of targeting‐mediated endocytosis over time. After being internalized by tumor cells selectively, chemodrug and therapeutic genes can achieve a superior tumor inhibited effect. By utilizing the multi‐channel fluorescence, this ternary complex could achieve precisely monitoring the targeted binding process of DDS and delivery processes of therapeutic agents.

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Section: Resultsmentioning

confidence: 99%

Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug

Yuan

Dong

et al. 2021

Advanced Optical Materials

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“…For cell membrane fluorescent probes, accuracy and firmness are the premise, but the photostability of dyes is also important. Fortunately, AIEgen has excellent photobleaching resistance property, [47][48][49][50][51][52][53][54][55][56][57][58][59][60] which makes it ideal for long-term imaging. Therefore, the photostability of RTP was evaluated.…”

Section: Page 14 Of 25 Ccs Chemistrymentioning

confidence: 99%

Peptide-Conjugated Aggregation-Induced Emission Fluorogen: Precise and Firm Cell Membrane Labeling by Multiple Weak Interactions

Yang¹,

Hu²,

Wei³

et al. 2022

CCS Chem

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Cell membrane is a vital barrier to protect the cell from outside damage and involved in many biochemical processes. It is of great significance to label the cell membrane to explore its function. However, due to the complex and dynamic nature of cell membrane, precisely and firmly labeling the cell membrane simultaneously is still a challenge. Herein, we report a peptide-conjugated aggregation-induced emission fluorogen (AIEgen), named RTP. RTP mainly consists of three components. (1) RGD peptide (R), which can specifically bind to integrin  v  3 on cell membrane through ligand-receptor interaction. ( 2) T-MY (T), an AIE-active tetraphenylethene derivative for fluorescent imaging. (3) Palmitic acid modified peptide Pal-RRRR (P), in which Pal is inserted into the lipid on the cell membrane by hydrophobic interaction, and RRRR is combined with the negatively charged cell membrane through electrostatic interaction. RTP can precisely label the tumor cells with high integrin  v  3 expression, firmly trace the cell membrane for up to 4 hours, and has strong resistance to photobleaching. Moreover, RTP achieves tumor specific imaging by labeling cell membrane in vivo. Utilizing multiple weak interactions between the fluorescent probe and cell membrane provides a new strategy for precise and firm imaging of cell membrane simultaneously.

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“…[61][62][63][64] This enables the creation of tailor-made AIEgenic aggregates, with control over their physicochemical properties in a facile manner, concerning size, shape, morphology, flexibility, surface chemistry (for instance charge and site-targeting ligands) and stability (including both disassembly kinetics and stimuli-responsive pathways). [65][66][67][68][69][70] Co-assembly strategies increase the variety in AIEgenic assemblies even further. [25] In this review, we mainly cover the topic of amphiphilic polymeric self-assemblies with AIE properties and summarize the recent progress in their design, synthesis, selfassembly, fluorescent behavior and biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

et al. 2021

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Aggregation-induced emission (AIE) is a phenomenon in which fluorescence is enhanced rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible, conjugated systems that are limited in their dynamics when assembled, which improves their fluorescent properties. This intriguing feature has been incorporated in many different molecular assemblies and has been extended to nanoparticles composed of amphiphilic polymer building blocks. The integration of the fascinating AIE design principle with versatile polymer chemistry opens up new frontiers to approach and solve intrinsic obstacles of conventional fluorescent materials in nanoscience, including the aggregation-caused quenching effect. Furthermore, this integration has drawn significant attention from the nanomedicine community, due to the additional advantages of nanoparticles comprising AIEgenic molecules, such as emission brightness and fluorescence stability. In this regard, a range of AIEgenic amphiphilic polymers have been developed, displaying enhanced emission in the self-assembly/aggregated state. AIEgenic assemblies are regarded as attractive nanomaterials with inherent fluorescence, which display promising features in a biomedical context, for instance in biosensing, cell/tissue imaging and tracking, as well as (photo) therapeutics. In this review, we describe recent strategies for the design and synthesis of novel types of AIEgenic amphiphilic polymers via facile approaches including direct conjugation to natural/synthetic polymers, polymerization, post-polymerization and supramolecular host−guest interactions. Their self-assembly behavior and biomedical potential will be discussed.

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Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

Cited by 143 publications

References 138 publications

Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug

Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug

Peptide-Conjugated Aggregation-Induced Emission Fluorogen: Precise and Firm Cell Membrane Labeling by Multiple Weak Interactions

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

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