Enzyme Inhibition by Lead Under Normal Urban Conditions

Hernberg, Sven; Nikkanen, J.

doi:10.1016/s0140-6736(70)91846-5

Cited by 173 publications

(43 citation statements)

References 10 publications

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“…Our observations, together with -the reports of inhibition of AmLev dehydratase (22), confirm the hypothesis of Patterson that, even at the low level of exposure of the general population, adverse biological effects of Pb can be demonstrated ifsearched for with adequate techniques.…”

supporting

confidence: 89%

“…Selander and Cramer reported that urinary AmLev excretion accelerated at BPb >40, a value at the time accepted as the upper limit of normalcy (24). Because it is well established that AmLev dehydratase is significantly inhibited at BPb <40 (22), the failure to acknowledge any accumulation ofAmLev at low doses of Pb made it necessary to postulate a "reserve capacity" of the enProc. Nad Acad.…”

mentioning

confidence: 99%

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Threshold for lead damage to heme synthesis in urban children.

Piomelli¹,

Seaman²,

Zullow³

et al. 1982

Proc. Natl. Acad. Sci. U.S.A.

106

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Although lead has no physiological function and is present in only negligible amounts in the blood of remote populations, it has become customary to accept the usual blood Pb level(s) (BPb) observed in industrialized society as "normal." Pb interferes with many biochemical systems, among them the heme biosynthetic pathway; this is reflected by an exponential increase in erythrocyte protoporphyrin concentration (EP) as BPb increases. The present study estimated the threshold BPb at which an increase of EP occurs in a population of urban children. In the 2,004 children studied, BPbs ranged from 2 to 98 jug/dl, with

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supporting

confidence: 89%

mentioning

confidence: 99%

Threshold for lead damage to heme synthesis in urban children.

Piomelli¹,

Seaman²,

Zullow³

et al. 1982

Proc. Natl. Acad. Sci. U.S.A.

106

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“…ô-Aminolevulinate dehydratase (ALA-D; prophobilinogen synthase, EC 4.2.1.24) activity in red cells is widely accepted as the most sensitive indicator of lead poisoning in man and animals (7,11,16,20). It is a sulfhydral enzyme found in the cytoplasma of all aerobic cells which synthesize heme.…”

mentioning

confidence: 99%

Effect of Phenylhydrazine on Delta-Aminolevulinic Acid Dehydratase in Red Blood Cells

Abdulla¹,

Svensson²

1978

Enzyme

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δ-aminolevulinic acid dehydratase activity was measured in the blood of rats poisoned by successive injections of phenylhydrazine (1 ml, 35 mmol). After 5 days of successive injections, more than 90% of the circulating blood cells consisted of reticulocytes and the enzyme activity also increased successively and reached a maximum corresponding to the number of reticulocytes. Thus ô-aminolevulinic acid dehydratase activity measured in the peripheral blood is mainly due to the percentage of circulating reticulocytes.

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“…The threshold blood lead level for G-ALAD activity is less than 10 Pg/dL in adults and children. (6). There are eight variants of this gene described in literature but one polymorphism that yields two polymorphic alleles -ALAD-1 and ALAD-2, have been implicated in susceptibility to lead toxicity (7).…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to lead poisoning—A case report

Bijoor

Venkatesh

2007

Indian J Clin Biochem

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Lead poisoning is well documented in persons occupationally exposed to lead. What is less known is, that even in persons working in lead based CASE REPORTA 30-year old male working in a lead acid battery factory for over 6 years came to our laboratory, at the National Referral Centre for lead poisoning in India, Bangalore, wanting to check out his blood lead levels after his friend, who had abdominal pain and weakness of the right arm was detected to have high blood lead levels. He was totally asymptomatic. On examination, he was found to be a middle aged male, well built and well nourished. There was no pallor, icterus or cyanosis. His pulse, blood pressure and other vital signs were normal. Systemic examination including that of the central nervous system did not reveal any abnormality.Blood investigations were done and the findings were as follows (Values in parenthesis indicate normal range) : Haemoglobin = 14.3gms/dl (13-18gms/dl), Total count = 9900 (4000-11000), Differential count -Neutrophils = 49% (40-75%), Lymphocytes = 37% (20-45%), Eosinophils = 11%(1-6%), Myelocytes =2%(<1%), Metamyelocytes =1%(<1%), Platelets = 2.25 lacs/ml (1.5-4.1 lacs/ml) and Blood lead = 82.8Pg/dl (<10Pg/dl)

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Enzyme Inhibition by Lead Under Normal Urban Conditions

Cited by 173 publications

References 10 publications

Threshold for lead damage to heme synthesis in urban children.

Threshold for lead damage to heme synthesis in urban children.

Effect of Phenylhydrazine on Delta-Aminolevulinic Acid Dehydratase in Red Blood Cells

Genetic susceptibility to lead poisoning—A case report

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