Enzyme-functionalized gold-coated magnetite nanoparticles as novel hybrid nanomaterials: Synthesis, purification and control of enzyme function by low-frequency magnetic field

Gribanovsky

Journal of Controlled Release

et al. 2015

192

156

The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia.

Section: Observation Of Magneto-mechanical Actuation In Biologicalsupporting

confidence: 83%

Section: Observation Of Magneto-mechanical Actuation In Biologicalmentioning

confidence: 99%

Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields

Gribanovsky

Journal of Controlled Release

et al. 2015

192

156

Front. Bioeng. Biotechnol.

“…For instance, gold nanoparticles conjugated with specific oligonucleotides can sense complementary deoxyribonucleic acid (DNA) strands, detectable by color changes (Kouassi and Irudayaraj, 2006). Furthermore, gold nanoparticles can be readily functionalized with antibodies and oligonucleotides (Orendorff et al, 2006;Yu and Irudayaraj, 2007;Sun and Irudayaraj, 2009a,b;Wang et al, 2010;Wang and Irudayaraj, 2013;), enzymes (Majouga et al, 2015). These hybrid nanostructures are also active elements of a number of biosensor assays to detect gene products in plants (Kadam et al, 2014(Kadam et al, , 2017, drug and gene delivery systems (Ding et al, 2014).…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

200

107

The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

“…The energy of magnetic field dissipates when magnetic moment relaxes to equilibrium state. [103,104] For instance, Klyachko et al [103] studied the rate of enzymatic reactions of enzymes coupled with magnetic nanoparticles under low-frequency and RF magnetic field. [102] One should note that both of these processes always occur simultaneously, however, the impact of particular relaxation mechanism depends on the applied frequency and amplitude of magnetic field, particle size, and environment.…”

Section: Triggering Of the Capsules By Alternate Magnetic Fieldmentioning

confidence: 99%

Inorganic/Organic Multilayer Capsule Composition for Improved Functionality and External Triggering

Timin

Gao

Voronin

et al. 2016

Adv Materials Inter

Polyelectrolyte (PE) and nanocomposite (NC) microcapsules fabricated by layer‐by‐layer technique have been of great interest in the past decade as novel entities for cargo encapsulation and delivery as well as for diagnostic purposes. The unique physicochemical properties of polymers and inorganic nanoparticles used in layer‐by‐layer synthesis of PE and NC microcapsules make them promising in various fields, such as storage, catalysis, cells imaging, controlled drug release, and targeted drug delivery. However, the requirement of the cargo encapsulation is that the cargo should have a relatively large molecular weight in order to avoid the leakage from the capsules. In this review, recent progress in the design and functionalization of PE and NC microcapsules using sol–gel method for storage of small cargos have been presented. Moreover, various remote exposures on the permeability of organic/inorganic composite microcapsule shells such as ultrasound, magnetic field gradient, laser, and microwave radiation have been observed. Finally, the description and discussion of the new trends and perspectives for improved functionality of PE microcapsules are the major topic of this progress report.