Enzymatic synthesis of chiral intermediates for pharmaceuticals

Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.

Overview of Chirality and Chiral Drugs

“…The reaction is complete in about 3 h with reaction yields of 92% and >99% ee for (S )-6-hydroxynorleucine 11 (Fig. 1.9) [18]. There are some exceptions and limitations to the enzymatic-catalyzed reactions.…”

Enantioselective synthesis of (S)-phenylephrine by whole cells of recombinant Escherichia coli expressing the amino alcohol dehydrogenase gene from Rhodococcus erythropolis BCRC 10909

“…Chiral aryl alcohols are important chiral building blocks for the production of optically active drugs in the pharmaceutical and agrochemical industries [15][16][17]. They can be obtained by asymmetric reduction of prochiral aryl ketones using oxidoreductases.…”

Novel Strategy for Protein Exploration: High-throughput Screening Assisted with Fuzzy Neural Network

“…[2][3][4] Enzymes, which are the biological enantioselective proteins, have been the key tool for the effective synthesis of these compounds.…”