Overview of Chirality and Chiral Drugs

Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling

“…Considering the fact that more than 50% of all pharmaceuticals are chiral drugs (Lin et al, 2011), this indicates a need for investigating enantioselective toxic effects of chiral drugs and racemic mixtures already on the marked. Especially chiral and racemic drugs sold in large quantities, particularly those available over-the-counter should be investestigated for enantioselective side effects.…”

Investigation of the Mechanism of Racemization of Litronesib in Aqueous Solution: Unexpected Base‐Catalyzed Inversion of a Fully Substituted Carbon Chiral Center

“…Achiral degradation pathways involving base-catalyzed $-elimination reactions. Pathway (A) yields degradation product (3). Pathway (B) shows the proposed pathway to degradation product (4).…”

“…The maintenance of chiral integrity during manufacture, formulation, storage, and distribution is of paramount importance and is a critical aspect of the development of safe and effective drugs. [1][2][3] This paper describes an unexpected racemization reaction observed with a novel drug candidate.…”

Enantioselective Synthesis of β‐Methyl Amines via Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Sulfonyl Allyl Amines

“…Chiral amines are key structural features in natural products and fine chemicals. [1,2] Amines bearing a βmethyl stereogenic center are present in numerous bioactive compounds and pharmaceuticals. [3][4][5] Several examples of this type of drugs are shown in Figure 1.…”