Enzymatic Porphyrin Synthesis in Harderian Glands and Other Organs and Tissues of Mice.

Davidheiser, Roger H.; Figge, Frank

doi:10.3181/00379727-90-22065

Cited by 11 publications

(4 citation statements)

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“…In rodents, this gland is one of the most active sites of both porphyrin and lipid biosynthesis known (Davidheiser and Figge, 1955;Margolis, 1971;Jost et al, 1974). Porphyrin amounts are visible as brown pigment accretions within the alveolar lumens (Kennedy, 1970;Johnston et al, 1985).…”

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confidence: 99%

Postnatal development of the harderian gland in the Syrian golden hamster (Mesocricetus auratus): A light and electron microscopic study

1992

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The main objective of the present investigation was to study the morphological and chronological aspects of the development of the Harderian gland in the Syrian golden hamster. Tissues were obtained from male and female hamsters at days 1,3,5,7,10,12,15,17,20,27,37,46, and 90 after birth and processed for light and transmission electron microscopy. The present observations indicate that a well-defined temporal sequence in microscopic and ultrastructural modification is recognizable in the development of the hamster Harderian gland. Four stages of development were proposed. Between days 1-5 (first stage), the gland shows characteristics of an immature structure. The glandular cells contain many free ribosomes, few and small organelles, and large irregular-shape nuclei. Between days 7-17 (second stage), there is a marked increase of organelles involved in synthesis and secretion. The gland begins the secretion of lipids and porphyrins, but no morphological differences between male and female glands are observed. Between days 20-36 (third stage), the morphological differences between the two sexes appear and progressively develop. In 45-day-old hamsters, the Harderian gland possesses the structural characteristics of adult glands, and further developmental changes are essentially quantitative in nature (fourth stage). At all stages of development, the population of secretory cells has a uniform appearance. The morphological results are discussed as well as the possible relationship of this temporal sequence with hormonal changes.

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Postnatal development of the harderian gland in the Syrian golden hamster (Mesocricetus auratus): A light and electron microscopic study

1992

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“…According to Thomas [1938] the Harderian gland in the rat synthesises the porphyrin directly, rather than passively excreting porphyrins brought by the circulation. Recent studies in the mouse support the concept that the gland is actively producing the porphyrin [Cohn, 1955;Davidheiser and Figge, 1955]. The histology of the Harderian gland of the albino rat has been fully described by Grafflin [1942].…”

Section: Introductionmentioning

confidence: 78%

Pigment in the Harderian Glands of Mice Exposed to a Hot Environment

Collins

1957

Exp Physiol

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“…It is well known that HG of several rodents is capable of porphyrin biosynthesis (Davidheiser and Figge, 1955;Tomio and Grinstein, 1968;Margolis, 1971). These glands contain grossly visible amounts of porphyrin which exhibit a characteristic red fluorescence in the UV range (Derrien and Turchini, 1924;Grafflin, 1942).…”

Section: Discussionmentioning

confidence: 99%

An electron microscopic study of the harderian gland of the Syrian hamster with particular reference to the processes of formation and discharge of the secretory vacuoles

Tolivia

Alvarez-Uría

et al. 1993

Anat. Rec.

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The lipid-secreting cells of the Harderian gland of the Syrian hamster were studied using light, transmission, and scanning electron microscopy. Three morphologically different secretory cell types are identified in the gland: type I and II cells of the male gland and, distinct from either, the female gland cell. In all secretory cell types, lipid droplets in the cytoplasm were surrounded by unit membranes. Ultrastructural evidence of the involvement of the Golgi apparatus in the formation of the secretory vacuoles was obtained. The process of secretion involved the fusion of the boundary unit membrane of the vacuole with the plasma membrane and the release of the vacuolar content alone into the lumen. No evidence of holocrine processes was observed in this study. In addition to lipids, vacuoles contained materials whose solubility properties clearly differed from those of lipids. There appear to be variations in the ultrastructural characteristics of the vacuole content of the different types of secretory cell.

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Enzymatic Porphyrin Synthesis in Harderian Glands and Other Organs and Tissues of Mice.

Cited by 11 publications

References 0 publications

Postnatal development of the harderian gland in the Syrian golden hamster (Mesocricetus auratus): A light and electron microscopic study

Postnatal development of the harderian gland in the Syrian golden hamster (Mesocricetus auratus): A light and electron microscopic study

Pigment in the Harderian Glands of Mice Exposed to a Hot Environment

An electron microscopic study of the harderian gland of the Syrian hamster with particular reference to the processes of formation and discharge of the secretory vacuoles

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