Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices

Buaki-Sogo, Mireia; García-Carmona, Laura; Gil-Agustı́, Mayte; Zubizarreta, Leire; García-Pellicer, Marta; Quijano-López, Alfredo

doi:10.1007/s41061-020-00312-8

Cited by 14 publications

(14 citation statements)

References 132 publications

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“…It can be divided into microbial biofuel cells (microorganism as the catalyst, E. coli, actinobacteria, et al), [137] abiotic biofuel cells (the catalyst is inorganic species, Pt, Au, et al) [138] and enzymatic biofuel cells (the catalyst is an enzyme, glucose oxidase, D-glucose dehydrogenase, et al) depending on the catalyst. [139] Most of the designed biofuel cells are the production of microscale power, [140] which can be used as wearable and implan energy collection devices for blood, sweat, saliva, and other human biofluids to convert lactic acid [141] or glucose into electrical energy. [60,142] In the field of electrical stimulation DDS, biofuel cells have many application scenarios.…”

Section: Biofuel Cellmentioning

confidence: 99%

“…depending on the catalyst. [ 139 ] Most of the designed biofuel cells are the production of microscale power, [ 140 ] which can be used as wearable and implan energy collection devices for blood, sweat, saliva, and other human biofluids to convert lactic acid [ 141 ] or glucose into electrical energy. [ 60,142 ]…”

Section: Self‐powered Electrical Stimulation Drug Delivery Systemmentioning

confidence: 99%

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Self‐Powerbility in Electrical Stimulation Drug Delivery System

Yang

Mao

et al. 2021

Adv Materials Technologies

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On‐demand drug delivery is one of the main research directions of the drug delivery system (DDS). At present, with the development of various stimulus‐responsive materials and technology, it is possible to regulate drug release through various external or internal stimuli. Among them, electrical stimulation DDS has great potential due to its easy combination with sensor or microchip and precise time and space controlled‐release ability. At the same time, with the rapid growth of research in self‐powered devices, the self‐powerbility of electrical stimulation DDS has also received a lot of attention. In this review, the current biomaterials used in electrical stimulation DDS, such as conducting polymers, electroconductive hydrogels, carbon‐based nanomaterials, metal, and semiconductors are first introduced. Further the route of administration and recent advances of electrical stimulation DDS is summarized. The development and classification of self‐powered devices used in DDS are highlighted. In the end, the major challenges and future perspectives of electric stimuli‐responsive DDS are discussed.

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Section: Biofuel Cellmentioning

confidence: 99%

Section: Self‐powered Electrical Stimulation Drug Delivery Systemmentioning

confidence: 99%

Self‐Powerbility in Electrical Stimulation Drug Delivery System

Yang

Mao

et al. 2021

Adv Materials Technologies

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“…Conventional mediator molecules, such as ferricyanide, phenazine derivatives, and quinone derivatives, are soluble in water and freely diffuse into the active sites deep inside the protein shell of these enzymes. [ 9–16 ] However, enzymatic fuel cells with diffusing mediators require undesirable complex components (i.e., semipermeable membranes) to prevent the crosstalk that occurs between the anode and cathode systems. In addition, continuous glucose monitoring has been considered for diabetes management, [ 17 ] which requires that the leakage of mediators should be prevented.…”

Section: Figurementioning

confidence: 99%

Enzyme electrode for glucose oxidation using low‐solubility 4‐aminodiphenylamine derivatives as electron mediator

Masakari

Totsuka

Shinohara

et al. 2021

Electrochemical Science Adv

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A novel enzyme electrode system for glucose oxidation was constructed by co-immobilization of glucose dehydrogenase (GDH) and N,N'-diphenyl-pphenylenediamine (DPPD) on carbon electrodes. This enzyme electrode system was applied to porous carbon fabric to produce a glucose oxidation current of 7 mA/cm 2 , while the electrode catalytic activity was maintained at approximately 100% for more than 4 h, indicating that DPPD molecules were stably retained on the electrodes during the continuous redox cycling. Further, a stable mediation was also observed for other 4-aminodiphenylamine derivatives similar to DPPD.The difference was found in the adsorptivity between the reduced and oxidized forms of DPPD on the carbon electrode, suggesting that a portion of oxidized DPPD can access the active center of GDH without desorbing to solution. This electrode system with 4-aminodiphenylamine derivatives can be used in sensors for glucose monitoring and to anodes of separator-free glucose fuel cells. K E Y W O R D S4-aminodiphenylamine derivatives, enzymatic fuel cells, enzyme electrode, glucose dehydrogenase, mediator Enzyme-modified electrodes are the core components of bioelectronic devices, such as biosensors, for medical analytes and biofuel cells. These types of electrodes can generate electricity from natural fuel molecules, such as glucose. [1][2][3][4][5][6][7][8][9][10][11] Most of these bioelectronic devices employ a mediated electron transfer between the enzyme active sites and electrode surface via a redox-active molecule called mediator. Conventional mediator molecules, such as ferricyanide, phenazine derivatives, and quinone derivatives, are soluble in water and freely diffuse into the active sites deep inside the protein shell of these enzymes. [9][10][11][12][13][14][15][16] However, enzymatic fuel cells with diffusing mediators require undesirable complex components (i.e., semiper-This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Glucose BFCs consist of biodevices aimed to harvest energy from human body due to the catalytic electrochemical oxidation of glucose as a result of the selective recognition of a substrate (glucose) by the enzyme, typically glucose oxidase (GOx) or glucose dehydrogenase (GDH). Thus, low cost and availability of the enzymes are required, together with stable immobilization methods on the surface such as crosslinking, entrapment, covalent anchorage to allow stability of the binding for the long term use [7]. However, advances in wearable technologies need for new electrode configurations that can be placed anywhere in the body.…”

Section: Introductionmentioning

confidence: 99%

Development of Flexible, Conductive and Biocompatible Chitosan-Based Miniaturized Bioelectrodes for Enzymatic Glucose Biofuel Cells

et al. 2022

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The need for new clean energy sources for portable devices in biomedical, agro-food industry and environmental related sectors boosts scientists towards the development of new strategies for energy harvesting for their application in biodevices development. In this sense, enzymatic biofuel cells (BFCs) have gained much attention in the last years. This work faces the challenge of develop new generation of BFCs able to be adapted to remote and personal monitoring devices within the framework of wearable technologies. To this aim, one of the main challenges consists of the development of conductive and biocompatible electrodes, which constitute a challenge itself due to the non-conductive capabilities of most of the biocompatible supports. Additionally, bioelectrodes may achieve good mechanical properties and resilience in order to be suitable for the envisioned application, which involves exposure to deformation during long-term use. Furthermore, it is desirable that the systems developed are versatile enough to be adapted to miniaturized supports for new personal wearable devices development. In the present work, self-standing chitosan-carbon black membranes have been synthesized and modified with suitable enzymes for the assembly of an enzymatic glucose BFC. The membranes have been adapted to be integrated in miniaturized interdigitated gold electrodes as the step forward to miniaturized systems, modified with enzymes and metallic particles clusters and tested for energy harvesting from glucose solutions. The miniaturized system produces a power density of 0.64 µW/cm2 that is enhanced to 2.75 µW/cm2 in the presence of the metallic clusters, which constitute a 76% incensement. Such preliminary demonstrations highlight the good response of metals in bioelectrode configuration. However, energy harvesting real application of the developed miniaturized electrodes need still improvements but pave the way for the use of BFC as an energy source in wearable technologies due to their good mechanical, electrical and biocompatible properties.

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Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices

Cited by 14 publications

References 132 publications

Self‐Powerbility in Electrical Stimulation Drug Delivery System

Self‐Powerbility in Electrical Stimulation Drug Delivery System

Enzyme electrode for glucose oxidation using low‐solubility 4‐aminodiphenylamine derivatives as electron mediator

Development of Flexible, Conductive and Biocompatible Chitosan-Based Miniaturized Bioelectrodes for Enzymatic Glucose Biofuel Cells

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