Enzymatic degradation of glycosaminoglycans in molluscs: Formation of glucuronic acid and N-acetylhexosamines from heparan sulfate and chondroitin sulfate by enzymes from three species of molluscs of the classes gastropoda and pelecypoda

Souza, J.Felipe de; Medeiros, Maria G.L.; Paiva, Vania M.P.; Nader, Helena B.; Dietrich, Carl P.

doi:10.1016/0305-0491(85)90230-5

Comparative Biochemistry and Physiology Part B: Comparative Bio

1985

DOI: 10.1016/0305-0491(85)90230-5

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Enzymatic degradation of glycosaminoglycans in molluscs: Formation of glucuronic acid and N-acetylhexosamines from heparan sulfate and chondroitin sulfate by enzymes from three species of molluscs of the classes gastropoda and pelecypoda

J.Felipe de Souza¹,

Maria G.L. Medeiros²,

Vania M.P. Paiva³

et al.

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Cited by 3 publications

References 7 publications

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Lectin-binding glycoproteins in the developing and adult snail CNS

Serfözö

Elekes

2009

Brain Struct Funct

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Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic (Lymnaea stagnalis) and a terrestrial (Helix pomatia) snail species, applying lectin histochemistry and blotting. Lectin probes that are specific for N-acetyl-glucosamine (GlcNAc) oligomers frequently appeared in anatomically different regions of the adult ganglia of both species, such as, the periganglionic sheath, the interperikaryonal space and the neuropil. Different GlcNAc residues were found to intensively glycosylate five, high-molecular weight proteins characteristic for the ECM of Lymnaea CNS and localized mainly in the interperikaryonal space. N-acetyl-galactosamine oligomers were less pronounced in the adult snail ganglia, they were detected only in the periganglionic sheath and the attached basement lamina. Apart from some similarities, the glycosylation pattern of proteins and the distribution of glycoproteins in the neuropil displayed significant differences in Lymnaea and Helix. All continuous and increasing level of and also transient presence of glycoproteins were detected during Lymnaea CNS development. Our results indicate a rich glycosylated pattern of specific proteins in the snail CNS, displaying remarkable species- and age-dependent changes which suggest the wide importance of protein glycosylation in the CNS of invertebrates.

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Lectin-binding glycoproteins in the developing and adult snail CNS

Serfözö

Elekes

2009

Brain Struct Funct

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New pathway of heparan sulphate degradation

Medeiros

Ferreira

Leite

et al. 1998

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Elaboration in type, primary structure, and bioactivity of polysaccharides derived from mollusks

Wang

Liu

et al. 2017

Critical Reviews in Food Science and Nutrition

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Over the past decades, numerous Mollusca species have received more attention in development and utilization as valuable bio-resources. Many efforts have been focused on investigating mollusk polysaccharides because of their rich content, ease of extraction, diversified sorts, specific structure, various biofunctions and potent activities. To date, many mollusks, especially species of gastropods, bivalves, or cephalopods, have been reported containing polysaccharide compounds in tissues with abundant amount, and most of polysaccharides are obtainable through combining techniques of extraction, separation and purification. The polysaccharides isolated from mollusks appeared with various structural and physicochemical characteristics, ranged from neutral polysaccharides and sulfated polysaccharides, to GAGs series (including Hep/HS, CS/DS, HA and similarities), even to heterogeneous glycan with high molecular weight. This review article provides comprehensive knowledge of recent researches on type classification, tissue origins and possible biofunctions of various polysaccharides from mollusks. The highlights were placed in structure variation including molecular weight, sulfation pattern, linkages and monomer compositions for repeating unit, and primary molecular construction of the mollusks polysaccharides. In addition, this article covers general information on exhibition of mollusks polysaccharide extracts or preparations in the various bioactivities, such as anticoagulant, antiatherogenic, antioxidant, immunomodulatory, antivirus and antitumor activities, which would reveal their possible potentials in medical application. Furthermore, the article presents a brief overview on several challenges and future scope in this field.

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Enzymatic degradation of glycosaminoglycans in molluscs: Formation of glucuronic acid and N-acetylhexosamines from heparan sulfate and chondroitin sulfate by enzymes from three species of molluscs of the classes gastropoda and pelecypoda

Cited by 3 publications

References 7 publications

Lectin-binding glycoproteins in the developing and adult snail CNS

Lectin-binding glycoproteins in the developing and adult snail CNS

New pathway of heparan sulphate degradation

Elaboration in type, primary structure, and bioactivity of polysaccharides derived from mollusks

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