Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

Abstract

TLIM: lipase from Thermomyces lanuginosus immobilized on particle silica gel.

Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives

“…The decrement in the yield of the reaction at a higher concentration of the enzyme is due to the aggregation of enzyme molecules, which affects the interaction between substrate and enzyme molecule due to the blockage of the active sites of the enzyme. 43 Fu et al have also reported that a higher enzyme loading did not raise the reaction yield. 43 b A set of control reactions was conducted to confirm the role of the developed catalyst (entries 6–8, Table 3 ).…”

Lipase‐catalyzed hydrazine insertion for the synthesis of N′‐alkyl benzohydrazides

“…Based on the experimental results and relevant studies, 9,47–50 a plausible mechanism of this lipase‐catalyzed hydrazine insertion is illustrated in Scheme 2. First, the carbonyl group of MBH ketone ( 1a ) was reacted spontaneously with phenylhydrazine ( 2a ) to generated the intermediate I via an aza‐Michael addition.…”

Lipase‐Catalyzed Synthesis of Anthrone Functionalized Benzylic Amines via a Multicomponent Reaction in Supercritical Carbon Dioxide

“…[39] Based on our experimental results and previous studies, a reasonable mechanism for this MCR is proposed in Scheme 3. [40][41][42] First, aldehydes (2) and sulfonamides (3) form 5 via spontaneous nucleophilic addition. Dehydration then generates sulfonamides via reversible reactions.…”