Enzymatic Activity Related to Human Serum Beta-Liprotein: Histochemical, Immuno-Electrophoretic and Quantitative Studies

Lawrence, S.H.; Melnick, P. J.

doi:10.3181/00379727-107-26824

Cited by 49 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the first hypothesis, BChE has been reported to attach to lipoproteins (Dubbs 1966;Lawrence and Melnick 1961). Moreover, certain apolipoproteins, such as apolipoproteins B (Namba et al 1992) and E (Namba et al 1991), are found in plaques, as are various sulphated glycosaminoglycans (Snow et al 1996), with which certain cholinesterases also interact (Kalaria et al 1992;Sine and Colas 1996).…”

Section: Discussionmentioning

confidence: 97%

Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease

et al. 2000

View full text Add to dashboard Cite

In confirmed late-onset (>65 years) Alzheimer's disease, we found a greater load, both of overall neuritic plaques and of cholinesterase-positive neuritic plaques, in the temporal cortex of carriers of the butyrylcholinesterase K variant (BCHE-K) aged <80 years than of all other patients. The differences were most striking in the case of cholinesterase-positive neuritic plaques. Among BCHE-K carriers, densities of such plaques were over six times higher in patients <80 years at death than in those >80 years (P=0.01). Furthermore, in subjects <80 years, BCHE-K carriers had nearly six-fold greater densities of these plaques than non-carriers (P=0.009). We consider three potential explanations for these findings: that the K variant binds more readily to plaque constituents, that it promotes fibril formation or that it induces aberrant neurite growth.

show abstract

Section: Discussionmentioning

confidence: 97%

Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Although the physiological role of BChE remains unknown, its participation in lipid metabolism has been suggested by different types of data. It was shown that subcutaneous fat and BChE activity are positively correlated (Berry et al, 1954), and a physical association between BChE and lipoproteins such as LDL (Lawrence and Melnick, 1961;Dubbs, 1966;Kutty and Acharya, 1972;Kutty et al, 1973Kutty et al, , 1975Kutty et al, , 1977Ryhä nen et al, 1982) as well as HDL (Ryhä nen et al, 1982) was reported. Positive associations of BChE activity and body weight are wellknown (Simpson, 1966;Cucuianu et al, 1968;Stueber-Odebrecht et al, 1985;Brock and Brock, 1990;Chautard-Freire-Maia et al, 1990).…”

mentioning

confidence: 99%

Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index

Souza

Picheth

Allebrandt

et al. 2004

American J Phys Anthropol

View full text Add to dashboard Cite

Butyrylcholinesterase activity has been shown to be positively associated with weight and body mass index (BMI). The present study was carried out to search for an association between variants of the BCHE gene and weight, stature, and BMI on the basis of means and variances compared between nonusual variants and their respective usual controls. Individuals bearing the atypical mutation (N = 52) did not differ from their usual phenotype controls (N = 104) in these parameters. The BCHE*U/BCHE*K individuals (N = 222) presented a significantly higher BMI variance than their BCHE*U/BCHE*U controls (N = 222, F = 1.40, P = 0.012). This higher BMI variance does not seem to be an isolated effect of the K mutation, but appears to be the result of an interaction between the K allele and the usual allele, since no such difference in variance was detected between BCHE*K/BCHE*K individuals (N = 23) and their BCHE*U/BCHE*U (N = 23) controls. These data may suggest a relation between variability in the BCHE locus itself and BMI. Individuals with the BCHE UF phenotype (N = 45) showed a significantly higher mean stature (about 3 cm more; P = 0.02) than their controls with the usual phenotype (N = 135). A role in cell proliferation has been proposed for BCHE, and since growth depends on the number of mitoses, it is not unexpected that variants of this enzyme may influence body stature in different ways. This study reports the first data on the relation of BCHE alleles to anthropometric characters.

show abstract

“…Individuals with higher weight presented higher mean BChE activity [2,13,14], It was shown that subcutaneous fat and BChE activity are positively correlated [15] and that higher mean enzyme activity is presented by obese and hyperlipemic subjects when compared with normal con trols [16][17][18]. A physical association be tween BChE and lipoproteins such as LDL [19][20][21][22][23][24][25] as well as HDL and VHDL [25] has been reported.…”

Section: Introductionmentioning

confidence: 99%

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

View full text Add to dashboard Cite

The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C₅ band staining (scored 1–6), 113 individuals had faint C₅ bands (scores 1–3) and 112 intense C₅ bands (scores 4–6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 ± 0.73 kg) when compared to their controls (70.59 ± 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C₅ bands, although showing a negative correlation between weight and C₅ band intensity, did not differ from their controls in mean weight.

show abstract

Enzymatic Activity Related to Human Serum Beta-Liprotein: Histochemical, Immuno-Electrophoretic and Quantitative Studies

Cited by 49 publications

References 0 publications

Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease

Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease

Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Contact Info

Product

Resources

About