Enzybiotics and their Potential Applications in Medicine

Borysowski, Jan; Górski, Andrzej

doi:10.1002/9780470570548.ch1

Cited by 9 publications

(15 citation statements)

References 90 publications

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“…Bacteriophage-derived lysins are enzymes that can degrade peptidoglycans in the bacterial cell wall in a species-selective manner (78, 79). They may be effective in cases where the lysin can reach a sufficient proportion of the pathogenic species in the host (for example, in extracellular infections that do not involve biofilms) and cure the infection before the host immune response inactivates the lysin.…”

Section: Targeting Resistancementioning

confidence: 99%

Fresh Approaches to Anti-Infective Therapies

Nathan

2012

Sci. Transl. Med.

146

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If discovery of new antibiotics continues to falter while resistance to drugs in clinical use continues to spread, society's medicine chest will soon lack effective treatments for many infections. Heritable antibiotic resistance emerges in bacteria from nonheritable resistance, also called phenotypic tolerance. This widespread phenomenon is closely linked to nonproliferative states in ways that scientists are just beginning to understand. A deeper understanding of the mechanisms of phenotypic tolerance may reveal new drug targets in the infecting organisms. At the same time, researchers must investigate ways to target the host in order to influence host-pathogen relationships. Government must reform the regulatory process for approval of new antibiotics. The private sector, government, and academia must undertake multiple, organized, multidisciplinary, parallel efforts to improve the ways in which antibiotics are discovered, tested, approved, and conserved, or it will be difficult to sustain the modern practice of medicine.

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Section: Targeting Resistancementioning

confidence: 99%

Fresh Approaches to Anti-Infective Therapies

Nathan

2012

Sci. Transl. Med.

146

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“…Combinatorial action of various beta-lactam antibiotics or mupirocin or gentamicin enhancing lysostaphin activity was reported by various groups (Polak et al, 1993, Climo et al, 2001, Kiri et al, 2002, LaPlante, 2007. Thus, it is concluded that lysostaphin is an effective agent as pre-and post-treatment option for staphylococcal infections though CoNS showed generally weaker effect than S. aureus (Borysowski and Gorski, 2009a). This was because of presence of higher amount of serine than glycine in peptidoglycan of coagulase-negative staphylococci (Kumar, 2008).…”

Section: Synergistic Effectsmentioning

confidence: 86%

“…Lysins are enzymes, consist of N-terminal catalytic domain and C-terminal bacterial cellwall binding domain, and are produced by bacteriophage that digests the bacterial cell wall (Fischetti, 2010, Borysowski andGorski, 2009a). LysK, highly specific for the genus Staphylococcus, was obtained from phageK, has been effectively used in the treatment of staphylococcal infections (O'Flaherty et al, 2005a).…”

Section: Lysinsmentioning

confidence: 99%

“…There are several reports of lysostaphin mediated lysis of clinically relevant antibiotic resistant staphylococcal strains. Lysostaphin which is readily absorbed onto catheter surfaces without losing lytic property shows promise in the prevention of catheter-related bloodstream infections caused by CoNS and S. aureus (Shah et al, 2004, Borysowski andGorski, 2009a). Lysostaphin has successfully eradicated nasal colonization of MSSA, MRSA and mupirocin-resistant S. aureus in experimental cotton rats .…”

Section: Lysostaphin As a Therapeutic Agentmentioning

confidence: 99%

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Staphylococcal Infection, Antibiotic Resistance and Therapeutics

Choudhury¹,

Panda²,

Sharma³

et al. 2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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“…Although lysozyme is active mainly against gram-positive bacteria with the exception of some strains of Staphylococcus aureus and Enterococcus faecalis (10), its activity against gram-negative bacteria can be facilitated by cationic peptides in saliva. Those cationic peptides are earlier shown to be able to stimulate permeability of the outer peptidoglycan cell layer of gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Oral Spray Containing Lysozyme and Cetylpyridinium: Subjective Determination of Patients with Tonsillopharyngitis

Catic

Mehić²,

Binakaj³

et al. 2016

Mater Sociomed

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Introduction:Tonsillopharyngitis (sore throat) is a common disease mainly related to the seasonal common cold. To relieve unpleasant symptoms and discomfort of acute tonsillopharyngitis associated with common cold, patients usually take some non-prescription drugs.The aim:The primary aim of this study was to assess subjective determinations of the efficacy and the safety/tolerability of an oral spray comprising a combination of lysozyme chloride and cetylpyridinium chloride in those patients.Material and methods:The study involved 1727 patients with tonsillopharyngitis associated with common cold and treated with the studied drug, in the period from December 2014 through March 2015.Results:In total, 95% of patients rated the studied drug to be well, very well and excellently effective. In 32% of patients, the symptoms were relieved 10 minutes after the application of the spray. Significant correlations were found between the two subjective assessments of the drug efficiency with the total of 74.11% (95% CI: 73.41, 77.47%) of patients who said that the feeling of pain in the throat completely disappeared after the drug administration, evaluated the impact/effect of the drug was very good or good (Pearson Chi Square=391.401, p<0.001). The effectiveness was significantly better in patients with up to two episodes of common cold a year (Pearson Chi Square=6.101; p=0.014). The studied drug was rated to be well, very well and excellently tolerated by 97% of patients.Conclusion:According to patients’ subjective assessment, the combination of lysozyme chloride and cetylpyridinium chloride in a formulation of spray can quickly, efficiently and safely resolve the symptoms of acute tonsillopharyngitis associated with common cold.

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Enzybiotics and their Potential Applications in Medicine

Cited by 9 publications

References 90 publications

Fresh Approaches to Anti-Infective Therapies

Fresh Approaches to Anti-Infective Therapies

Staphylococcal Infection, Antibiotic Resistance and Therapeutics

Efficacy and Safety of Oral Spray Containing Lysozyme and Cetylpyridinium: Subjective Determination of Patients with Tonsillopharyngitis

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