Environmental stress factors associated with toddler's diarrhoea

Dutton, Philip V.; Furnell, James R. G.; Speirs, A. L.

doi:10.1016/0022-3999(85)90011-x

Cited by 11 publications

(2 citation statements)

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“…A significantly higher mean eosinophil count was also present in the patients with CNSD compared with the controls, but the cause of these minor histopathological changes, which were not present in all the patients studied, is unknown. Several factors have been reported to cause CNSD (14)(15)(16)(17)(18)(19)(20), and in a recent publication some children with this disorder had a food allergy (4). In the present study, the histopathological changes in the patients with CNSD resembled those found in the group of patients with a cow's milk allergy but were less severe, and it is possible that a food allergy could have been a common factor in the pathogenesis of both of these disorders.…”

Section: Discussionmentioning

confidence: 99%

Morphometric Studies and Eosinophil Cell Counts in the Duodenal Mucosa of Children With Chronic Nonspecific Diarrhoea and Cow's Milk Allergy

Challacombe,

Wheeler,

Campbell

1986

J. pediatr. gastroenterol. nutr.

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SummaryMorphometric studies and eosinophil counts in the lamina propria of the duodenal mucosa have been performed in patients with chronic nonspecific diarrhoea and with persistent diarrhoea due to a cow's milk allergy, using a semiautomatic image analysing system. The results have shown that the mean eosinophil count was significantly higher in both of these groups of patients compared with a control group (p < 0.001), and some of the patients with chronic nonspecific diarrhoea had partial villous flattening. These findings in patients with chronic nonspecific diarrhoea could be related to the pathogenesis of this disorder.

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Section: Discussionmentioning

confidence: 99%

Morphometric Studies and Eosinophil Cell Counts in the Duodenal Mucosa of Children With Chronic Nonspecific Diarrhoea and Cow's Milk Allergy

Challacombe,

Wheeler,

Campbell

1986

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…In this issue of JPGN, Bailey et al propose that bacterial colonization of the gut might be impacted by stress in the pregnant mother (29). Stress is presumed to suppress normal mucosal immunity and enhance the growth of enteric pathogens by enhancing the secretion of stressinduced neurohormones (30)(31)(32)(33)(34)(35). Previous work by Bailey and Coe (36), also in infant rhesus monkeys, suggests that the stress produced by the disruption of the maternal-infant bond may increase vulnerability to disease.…”

mentioning

confidence: 99%