Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys

Bailey, Michael T.; Coe, Christopher L.

doi:10.1002/(sici)1098-2302(199909)35:2<146::aid-dev7>3.0.co;2-g

Cited by 433 publications

(254 citation statements)

References 43 publications

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“…Maternal separation in infant rhesus monkeys leads to a reduction in lactobacilli and the emergence of enteric pathogens such as Campylobacter jejuni [75]. Similarly, studies simulating stress induction via maternal separation of rat pups show increase in stress response, cytokine response, intestinal permeability, and a shift in GI tract bacterial composition [76].…”

Section: Gut Microbiota and Brain Functionmentioning

confidence: 84%

What the Gut Can Teach Us About Migraine

Hindiyeh

Aurora

2015

Curr Pain Headache Rep

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During gestation, cells of the brain and gut develop almost simultaneously into the central nervous system (CNS) and enteric nervous system (ENS), respectively. They remain connected via the vagal nerve lifelong. While it is well known that the brain sends signal to the gut, communication is in fact bidirectional. Just as the brain can modulate gut functioning, the gut, and likely what we ingest, can in fact influence our brain functioning. We will first review both gastrointestinal (GI) function and migraine pathophysiology and then discuss evidence linking the migraine brain to various GI disorders. Lastly, we discuss the effects of gut microbiota on brain functioning and speculate how the gut and particularly diet may affect migraine.

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Section: Gut Microbiota and Brain Functionmentioning

confidence: 84%

What the Gut Can Teach Us About Migraine

Hindiyeh

Aurora

2015

Curr Pain Headache Rep

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“…Indeed, it has been shown that stressful experience can lead to altered gastrointestinal motility, secretions, and blood flow; while, in turn, such alteration in gastrointestinal function is transmitted to the brain and can ultimately bring about the perception of visceral events such as nausea, satiety, and pain [8]. Interestingly, a number of research papers reported that physical and psychological stress can affect the composition of intestinal microbiota in rodents [9][10][11] and primates [12,13]. Our previous works [4], in which colonizing microbes altered HPA response to restraint stress, showed that the interaction of gut bacteria with the brain is also bi-directional, just as the dBrainGut axisT.…”

Section: Discussionmentioning

confidence: 99%

Stress and gut microbiota: Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response?

Sudo

2006

International Congress Series

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“…Stress effects upon the intestinal microbiome composition have also been described (Bailey & Coe, 1999) but while these studies have shown significant changes from the normal, they have not been well controlled for other variables such as diet, nor have more modern molecular analyses yet been used to analyze the effects of stress on the bacterial content of the bowel.…”

Section: Microbial Neuroendocrinologymentioning

confidence: 99%