Environmental risk factors for Parkinson's disease in an urban multiethnic community

Marder, Karen; Logroscino, Giancarlo; Alfaro, B.; Mejía, H.; Halim, Aris; Louis, Elan D.; Côté, Lucien J.; Mayeux, Richard

doi:10.1212/wnl.50.1.279

Cited by 56 publications

(28 citation statements)

References 4 publications

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“…Consistent findings of epidemiological studies associate between increased disease risk and such environmental factors as rural residence [Morano et al, 1994;Liou et al, 1997, Marder et al, 1998], farming [Semchuk et al, 1993;Liou et al, 1997;Gorell et al, 1998;Fall et al, 1999], the drinking of water from wells [Morano et al, 1994;Liou et al, 1997, Marder et al, 1998], and exposure to agricultural chemicals, pesticides, and/or herbicides [Semchuk et al, 1992;Semchuk et al, 1993;Liou et al, 1997;Gorell et al, 1998;Fall et al, 1999;Vanacore et al, 2002]. Recently, several models have been elaborated in which exposure of animals to various pesticide and herbicides has been used to induce Parkinsonism [Uversky, 2004, for review].…”

Section: Introductionmentioning

confidence: 99%

Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies

Moussa

Rusnak

Hailu

et al. 2008

Experimental Neurology

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Animal models treated with agricultural chemicals, such as rotenone, reproduce several degenerative features of human central nervous system (CNS) diseases. Glutamate is the most abundant excitatory amino acid transmitter in the mammalian central nervous system and its transmission is implicated in a variety of brain functions including mental behavior and memory. Dysfunction of glutamate neurotransmission in the CNS has been associated with a number of human neurodegenerative diseases, either as a primary or as a secondary factor in the excitotoxic events leading to neuronal death. Since many human CNS disorders do not arise spontaneously in animals, characteristic functional changes have to be mimicked by toxic agents. Candidate environmental toxins bearing any direct or indirect effects on the pathogenesis of human disease are particularly useful. The present longitudinal Magnetic Resonance Imaging (MRI) studies show, for the first time, significant variations in the properties of brain ventricles in a rotenonetreated (2mg/kg) mouse model over a period of 4 weeks following 3 days of rotenone treatment. Histopathological analysis reveals death of stria terminalis neurons following this short period of rotenone treatment. Furthermore, in vivo voxel localized 1 H MR spectroscopy also shows for the first time significant bio-energetic and metabolic changes as well as temporal alterations in the levels of glutamate in the degenerating striatal region. These studies provide novel insights on the effects of environmental toxins on glutamate and other amino acid neurotransmitters in human neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies

Moussa

Rusnak

Hailu

et al. 2008

Experimental Neurology

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“…Epidemiological studies have, to varying extents, implicated exposures such as pesticides, solvents, neurotoxic metals, well-water consumption, and rural residency 2,3 . Of these exposures, pesticides have most frequently returned a positive association, though not consistently.…”

Section: Introductionmentioning

confidence: 99%

Test–retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controls

Gartner

Battistutta

Dunne

et al. 2005

Parkinsonism & Related Disorders

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There is substantial disagreement among published epidemiological studies regarding environmental risk factors for Parkinson's disease (PD). Differences in the quality of measurement of environmental exposures may contribute to this variation. The current study examined the test-retest repeatability of self-report data on risk factors for PD obtained from a series of 32 PD cases recruited from neurology clinics and 29 healthy sex-, age-and residential suburb-matched controls. Exposure data were collected in face-to-face interviews using a structured questionnaire derived from previous epidemiological studies. High repeatability was demonstrated for 'lifestyle' exposures, such as smoking and coffee/tea consumption (kappas 0.70-1.00). Environmental exposures that involved some action by the person, such as pesticide application and use of solvents and metals, also showed high repeatability (kappas>0.78). Lower repeatability was seen for rural residency and bore water consumption (kappa 0.39-0.74). In general, we found that case and control participants provided similar rates of incongruent and missing responses for categorical and continuous occupational, domestic, lifestyle and medical exposures.

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“…A case-control study conducted in New York found that PD risk increases with education level (Marder et al, 1998). In contrast, Taylor et al (1999) showed that a high education level was protective factor in PD.…”

Section: Pd-related Factorsmentioning

confidence: 99%

Related factors and prevalence of Parkinson’s disease among Uygur residents in Hetian, Xinjiang Uygur Autonomous Region

Xl¹,

Luo²,

Hx³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to identify the factors related to and determine the prevalence of Parkinson's disease (PD) among Uygur residents in Hetian Prefecture, Xinjiang Uygur Autonomous Region. This population-based prospective cohort study used structured questionnaires to screen for factors related to PD. The prevalence in different age groups was analyzed, and PD risk was assessed using univariate and multivariate conditional logistic regression analysis. In total, 5932 subjects participated in the survey; of these, 88 individuals, all of whom were Uygurs, had PD. The overall prevalence of PD was 1.48% (1.32%) in people over the age of 45; the prevalence was 1.68% (1.59%) in men and 1.28% (1.36%) in women. The Fifth Population Census in China found the prevalence of PD in Hetian, Xinjiang, to be 1.32%. Single-factor results showed that exercise, social activities, and frequent consumption of nuts are protective factors for PD, and long-term pesticide exposure, family history of PD, and consumption of barbecued food were risk factors for this condition. Multi-factor conditional logistic regression analysis showed that participation in sports and social activities can reduce the risk of PD, whereas long-term pesticide exposure and family history of PD increases this risk. These results show that PD is caused by the interaction of several factors.

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Environmental risk factors for Parkinson's disease in an urban multiethnic community

Cited by 56 publications

References 4 publications

Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies

Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies

Test–retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controls

Related factors and prevalence of Parkinson’s disease among Uygur residents in Hetian, Xinjiang Uygur Autonomous Region

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