Environmental pollutants and breast cancer

Brody, Julia Green; Moysich, Kirsten B.; Humblet, Olivier; Attfield, Kathleen R.; Beehler, Gregory P.; Rudel, Ruthann A.

doi:10.1002/cncr.22655

Cited by 306 publications

(214 citation statements)

References 101 publications

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“…For example, toxicological studies point to the presence of organic solvents and distinct polycyclic aromatic hydrocarbons, which are not only mutagenic but may also be breast cancer promoters, acting as hormone disruptors. 61 When applying the recessive genetic model to the different tumor sites, a significant increase in risk for lung cancer was also observed, strengthening the possibility of a role of XPC Gln/Gln genotype in these tissues. For head and neck cancer, however, no association could be seen in the recessive genetic model.…”

Section: Discussionmentioning

confidence: 94%

XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

et al. 2008

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XPC participates in the initial recognition of DNA damage during the DNA nucleotide excision repair process in global genomic repair. Polymorphisms in XPC gene have been analyzed in case-control studies to assess the cancer risk attributed to these variants, but results are conflicting. To clarify the impact of XPC polymorphisms in cancer risk, we performed a meta-analysis that included 33 published case-control studies. Polymorphisms analyzed were Lys939Gln and Ala499Val. The overall summary odds ratio (OR) for the associations of the 939Gln/Gln genotype with risk of cancer was 1.01 (95% confidence interval (95% CI): 0.94 -1.09), but there were statistically significant associations for lung cancer, observed for the recessive genetic model (Lys/Lys þ Lys/Gln vs Gln/Gln), (OR 1.30; 95% CI: 1.113 -1.53), whereas for breast cancer a reduced but nonsignificant risk was observed for the same model (OR 0.87; 95% CI: 0.74 -1.01). The results for Ala499Val showed a significant overall increase in cancer risk (OR 1.15; 95% CI: 1.02 -1.31), and for bladder cancer in both the simple genetic model (Ala/Ala vs Val/Val) (OR 1.30; 95% CI: 1.04-1.61) and the recessive genetic model (Ala/Ala þ Ala/Val vs Val/Val) (OR 1.32; 95% CI: 1.06-1.63). Our metaanalysis supports that polymorphisms in XPC may represent low-penetrance susceptibility gene variants for breast, bladder, head and neck, and lung cancer. XPC is a good candidate for large-scale epidemiological case-control studies that may lead to improvement in the management of highly prevalent cancers.

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Section: Discussionmentioning

confidence: 94%

XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

et al. 2008

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“…l'exposition accidentelle à certains perturbateurs endocriniens (cohorte Seveso) [8] 1 . À partir de 2010, il nous est apparu à l'Académie de Médecine que contrairement aux pesticides, à la dioxine et aux polychlorobiphényles (PCB) pour lesquels des mesures d'interdiction ou de limitation avaient été proposées (par exemple le plan Ecophyto 2 , Grenelle de l'environnement), le cas d'autres perturbateurs endocriniens dont certains constituants des plastiques (BPA et phtalates) était débattu et méritait une attention particulière du fait de leur très large distribution.…”

Section: Perturbateurs Endocriniens Et Incidence Des Cancers Hormonodunclassified

“…Ceci est en accord avec la notion, établie par ailleurs, que la toxicité d'un perturbateur endocrinien augmente si un risque génétique est associé [1,6,8].…”

Section: Le Mécanisme De L'effet Toxique Du Bpa N'est Pas éLucidéunclassified

Bisphénol A et cancers hormono-dépendants

Rochefort

2013

Med Sci (Paris)

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“…Although it is considered that the development of breast cancer result of the interaction of genetic factors we do not yet know aetiology of breast cancer [1][2][3]. From 85 to 90% of cases remains unknown, although it is believed that environmental factors play a leading role and predicted breast carcinoma in 75% cases of cancer [4][5].…”

Section: Introductionmentioning

confidence: 99%

“…So, it is extremely rare in women younger than 20 years and among women with 80 years [19]. Only 0.8% of breast cancers develop in women younger than 30 years, and approximately 6.5% occurs between 30 and 40 years of life [4].…”

Section: Introductionmentioning

confidence: 99%

The Most Common New Cases of Breast Cancer among the Housewives: The Some Carcinogenic Determinants

PranjiÄ‡

Gledo

MaleÅ¡-BiliÄ‡

2014

Open Access Maced J Med Sci

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BACKGROUND: Numerous studies have observed risk factors for breast cancer. We aimed to investigate and assess the relationship between individual, social, occupational and environmental determinants of breast cancer using a questionnaire among 100 newly diagnosed female breast cancer patients and 100 control female subjects without cancer.METHODS: A case-control study using a family ambulatory based survey was conducted among 200 female patients from all municipalities of Zenica - Doboj Canton. New cases of breast cancer among subjects of experimental group (n = 100) were diagnosed between January 1, 2003 and December 31, 2007 using the institutional clinical procedure for breast cancer diagnosis. Data were obtained using a self - rated questionnaire specially designed for this research. The questionnaire contains a group of questions about individual and demographic data, occupational and environment characteristics, reproductive hystory, body mass index, life style and quality life factors.RESULTS: Fifty two percent of our examinees with breast cancer are housewives. There were no significant differences between the two groups and their subgroups except for prevalence of routine physical activity (P = 0.016), unemployment (P = 0.004), history arrival menopause (P = 0.012), and type of occupation/ workplace (P = 0.015) among subjects with breast cancer in relation to control subjects. We found significantly higher prevalence for failure to routine physical activity (P = 0.006), obesity (P = 0.009), unemployment (P = 0.001), unsecure existence (P = 0.015), and low level of education (P = 0.001) in housewives in relationship to others occupation.CONCLUSION: The most common new cases of breast cancer were among housewife. Inverse significantly link between breast cancer and poverty, arrival time of menopause and distant-cousin- degree family history were found. For most women, physical activity may reduce the risk of invasive breast cancer

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Environmental pollutants and breast cancer

Cited by 306 publications

References 101 publications

XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

Bisphénol A et cancers hormono-dépendants

The Most Common New Cases of Breast Cancer among the Housewives: The Some Carcinogenic Determinants

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