Environmental manipulation affects depressive-like behaviours in female Wistar-Kyoto rats

Mileva, Guergana; Bielajew, Catherine

doi:10.1016/j.bbr.2015.07.035

Cited by 32 publications

(25 citation statements)

References 68 publications

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“…Behavioural data for these cohorts have been reported in [34]. Briefly, we reported that EE reduces anhedonia in WKY and Wistar females.…”

Section: Resultsmentioning

confidence: 99%

“…However, as shown previously in our laboratory [47], WKY females have significantly higher serum corticosterone after a prolonged stressor. Additionally, female WKY animals show significantly more anxiety and depressive-like behaviours in the EPM and FST, respectively [34]. Therefore, while there does appear to be more diffuse labelling of GRs in the WKY hippocampus, the immune cytokine and behavioural data suggests that there is a dysregulation of the HPA axis in this animal model.…”

Section: Discussionmentioning

confidence: 99%

“…The light and dark cycle was regulated at 12 h of light and 12 h of dark. During PND 85 and PND 87, animals were again subjected to the elevated plus test and forced swim test as described by Mileva and Bielajew [34]. Animals were sacrificed at PND 96 by myocardial perfusion with 4% paraformaldehyde.…”

Section: Methodsmentioning

confidence: 99%

“…Following this, they were handled for 5 min a day for 20 days. Baseline behavioural tests including the elevated plus maze, forced swim test, and sucrose preference were carried out prior to environmental manipulation (as previously described in [34]). Six animals from each strain were randomly assigned to 1 of 3 environmental conditions for 30 days : (1) Environmental Enrichment (EE) - 6 animals in a multistory cage with toys, chain bridges, Nestlets®, wooden chewing blocks, multicoloured Plexiglas® houses, cardboard tubes, and unlimited access to a running wheel; (2) standard housing (SH) - 3 rats in 1 guinea pig cage, with dimensions 50 cm × 38 cm × 20 cm; and (3) isolated housing (IH) - 1 rat per small cage, dimensions 45 cm × 22 cm × 20 cm.…”

Section: Methodsmentioning

confidence: 99%

“…The same animals were used in a previous study describing their behavioural outcomes in response to environmental manipulation [34]. Because of the volume loss in the hippocampus associated with major depressive disorder, this study focused on the hippocampus as well as the amygdala, a key component of the limbic system responsible for much of the emotional reactions to stimuli.…”

Section: Introductionmentioning

confidence: 99%

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Strain Differences and Effects of Environmental Manipulation on Astrocytes (Glial Fibrillary Acidic Protein), Glucocorticoid Receptor, and Microglia (Iba1) Immunoreactivity between Wistar-Kyoto and Wistar Females

Mileva

Moyes²,

Syed³

et al. 2017

Neuropsychobiology

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Background: Depression is often associated with an increase in hypothalamic-pituitary-adrenal (HPA) axis reactivity and immune response. To investigate this relationship, we examined the consequences of environmental manipulation on the neural correlates of the HPA axis and immune response in an animal model of depression, the Wistar-Kyoto (WKY) rat. Additionally, female animals are often overlooked in preclinical research because of the hormone fluctuations inherent in the estrous cycle. Methods: Female rats were randomly assigned to 1 of 3 environments for 30 days: (1) environmental enrichment (EE), (2) standard housing (SH), and (3) isolated housing (IH). Immunoreactivity of astrocytes (glial fibrillary acidic protein [GFAP]), glucocorticoid receptors (GRs), and microglia (Iba1) in the hippocampus and amygdala were measured using immunohistochemistry. Results: WKY animals had significantly more GR staining area and Iba1 staining intensity and area in the CA1 of the hippocampus. In enriched Wistar rats, GFAP staining intensity and area were greater in the CA1. A trend towards a greater percent of area stained with GR was found in WKY animals as compared to that of the Wistar animals. This was due to WKY females in EE having significantly higher GR staining intensity and area in the amygdala as compared to that of animals in SH. Discussion: These strain differences lend support to the use of WKY animals as an animal model of depression. Furthermore, due to the effects of EE on GFAP and GR staining in WKY females, we suggest that EE can be used as an intervention to potentially alleviate the negative effects of depression.

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“…Behavioural data for these cohorts have been reported in [34]. Briefly, we reported that EE reduces anhedonia in WKY and Wistar females.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Strain Differences and Effects of Environmental Manipulation on Astrocytes (Glial Fibrillary Acidic Protein), Glucocorticoid Receptor, and Microglia (Iba1) Immunoreactivity between Wistar-Kyoto and Wistar Females

Mileva

Moyes²,

Syed³

et al. 2017

Neuropsychobiology

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Effects of Social Isolation and an Enriched Environment on Anxious-Depressive Behavior in Rats in Normal Conditions and after Early Proinflammatory Stress

Павлова

Broshevitskaya

Зайченко

et al. 2022

Neurosci Behav Physi

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Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals

Grigoryan

Павлова

Зайченко

2022

Neurosci Behav Physi

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This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social isolation, age from onset of social isolation, sex, species, and strain of animals, the nature of the model used, and other factors have been shown to have influences. The molecular-cellular mechanisms of development of anxiety and depression-like behavior under the influence of social isolation and the roles of the HHAS, oxidative and nitrosative stress, neuroinflammation, BDNF, neurogenesis, synaptic plasticity, as well as monoamines in these mechanisms are discussed. This review presents data on sex differences in the effects of social isolation, along with the effects of interactions with other types of stress, and the roles of an enriched environment and other factors in ameliorating the negative sequelae of social isolation.

show abstract

Environmental manipulation affects depressive-like behaviours in female Wistar-Kyoto rats

Cited by 32 publications

References 68 publications

Strain Differences and Effects of Environmental Manipulation on Astrocytes (Glial Fibrillary Acidic Protein), Glucocorticoid Receptor, and Microglia (Iba1) Immunoreactivity between Wistar-Kyoto and Wistar Females

Strain Differences and Effects of Environmental Manipulation on Astrocytes (Glial Fibrillary Acidic Protein), Glucocorticoid Receptor, and Microglia (Iba1) Immunoreactivity between Wistar-Kyoto and Wistar Females

Effects of Social Isolation and an Enriched Environment on Anxious-Depressive Behavior in Rats in Normal Conditions and after Early Proinflammatory Stress

Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals

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