Environmental influences on locomotor recovery following cortical lesions in rats.

Held, Jean M.; Gordon, James; Gentile, A. M.

doi:10.1037/0735-7044.99.4.678

Cited by 69 publications

(33 citation statements)

References 26 publications

(43 reference statements)

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“…8-OH-DPAT also lessened TBI-induced hippocampal CA3 and ChAT þ cell loss, which are new findings in this TBI paradigm. The data further showed that EE also improved motor and cognitive performance, a finding in agreement with previous reports from our laboratory (Hoffman et al, 2008b;Kline et al, 2007), and those of others (Gentile et al, 1987;Hamm et al, 1996;Held et al, 1985;Hicks et al, 2002;Passineau et al, 2001;Rose et al, 1987). EE also reduced CA3 and ChAT þ cell loss relative to the STD vehicle-treated controls.…”

supporting

confidence: 92%

Evaluation of a Combined Therapeutic Regimen of 8-OH-DPAT and Environmental Enrichment after Experimental Traumatic Brain Injury

Kline

McAloon²,

Henderson³

et al. 2010

Journal of Neurotrauma

126

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When provided individually, both the serotonin (5-HT 1A )-receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and environmental enrichment (EE) enhance behavioral outcome and reduce histopathology after experimental traumatic brain injury (TBI). The aim of this study was to determine whether combining these therapies would yield greater benefit than either used alone. Anesthetized adult male rats received a cortical impact or sham injury and then were randomly assigned to enriched or standard (STD) housing, where either 8-OH-DPAT (0.1 mg/kg) or vehicle (1.0 mL/kg) was administered intraperitoneally once daily for 3 weeks. Motor and cognitive assessments were conducted on post-injury days 1-5 and 14-19, respectively. CA1/ CA3 neurons and choline acetyltransferase-positive (ChAT þ ) medial septal cells were quantified at 3 weeks. 8-OH-DPAT and EE attenuated CA3 and ChAT þ cell loss. Both therapies also enhanced motor recovery, acquisition of spatial learning, and memory retention, as verified by reduced times to traverse the beam and to locate an escape platform in the water maze, and a greater percentage of time spent searching in the target quadrant during a probe trial in the TBI þ STD þ 8-OH-DPAT, TBI þ EE þ 8-OH-DPAT, and TBI þ EE þ vehicle groups versus the TBI þ STD þ vehicle group ( p 0.0016). No statistical distinctions were revealed between the TBI þ EE þ 8-OH-DPAT and TBI þ EE þ vehicle groups in functional outcome or CA1/CA3 cell survival, but there were significantly more ChAT þ cells in the former ( p ¼ 0.003). These data suggest that a combined therapeutic regimen of 8-OH-DPAT and EE reduces TBI-induced ChAT þ cell loss, but does not enhance hippocampal cell survival or neurobehavioral performance beyond that of either treatment alone. The findings underscore the complexity of combinational therapies and of elucidating potential targets for TBI.

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supporting

confidence: 92%

Evaluation of a Combined Therapeutic Regimen of 8-OH-DPAT and Environmental Enrichment after Experimental Traumatic Brain Injury

Kline

McAloon²,

Henderson³

et al. 2010

Journal of Neurotrauma

126

View full text Add to dashboard Cite

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“…3, the EC rats showed a significant increase of the levels of striatal extracellular DOPAC throughout the dark phase, compared to the IC rats. Such increase of DOPAC in the EC rats seems to be parallel with the findings that environmental enrichment results in beneficial consequences on locomotor recovery following cortical lesions [10]. DA, HVA, and 5-HIAA did not exhibit significant differences between the EC and the IC group.…”

Section: Diurnal Variations Of Extracellular Monoamine Levels Frosupporting

confidence: 83%

Diurnal Monoamine Variation in Young and Old Rats: A Microdialysis Study

Sano

Aoi

Azekawa

et al. 1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Environmental enrichment also produces improved outcome after neural injury (17) as noted in several experimental animal models of brain damage, including ablative lesions (18,19), focal or global ischemia (20)(21)(22), anoxia (23), lateral fluid percussion injury (24), teratologic agents (25), genetic defects (26), aging (27), and diseases (28). When enrichment is provided before and after cortical lesions, rats regain normal kinematics during locomotion (19).…”

Section: Introductionmentioning

confidence: 94%

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

Fischer

Péduzzi

2007

The Journal of Spinal Cord Medicine

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Background/Objective: The objective of this study was to determine the effect of environmental enrichment on the sensorimotor function of rats with chronic spinal cord injuries.Design: Adult Sprague-Dawley rats received a contusive injury of moderate severity at vertebral level T8 using a weight-drop device. Three months after injury, 1 randomized group (n ¼ 16) of rats was placed in an enriched environment, whereas the control group (n ¼ 16) remained housed in standard laboratory cages (2/cage).Methods: Animals were placed in an enriched environment for 4 weeks beginning at 3 months after injury. The enriched environment consisted of a large cage (5-6 rats/cage) with access to items such as tubes, ramps, and running wheel, with items changed daily.Main Outcome Measures: Functional evaluation consisted of the open field Basso, Beattie and Bresnahan (BBB) locomotor test and the tests that form the combined behavioral score (CBS). The CBS includes motor score, toe spread, placing, withdrawal, righting, inclined plane, hot plate, and swim tests. Behavioral testing was repeated 7 times before and after the period of intervention.Results: The group placed in the enriched environment scored significantly better on the BBB (ANOVA repeated-measures, P , 0.01) test and CBS (ANOVA repeated-measures, P , 0.01).Conclusions: Environmental enrichment results in significant functional improvement in animals with spinal cord injury even with a substantial delay in initiating treatment after injury. The features of an enriched environment that may be responsible for the improvement include social interactions, exercise, and novel items in an interesting environment. These findings suggest a continued plasticity of the chronically injured rat spinal cord and a possible therapeutic intervention for people with spinal cord injury. Spinal Cord Med. 2007;30:147-155 J

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Environmental influences on locomotor recovery following cortical lesions in rats.

Cited by 69 publications

References 26 publications

Evaluation of a Combined Therapeutic Regimen of 8-OH-DPAT and Environmental Enrichment after Experimental Traumatic Brain Injury

Evaluation of a Combined Therapeutic Regimen of 8-OH-DPAT and Environmental Enrichment after Experimental Traumatic Brain Injury

Diurnal Monoamine Variation in Young and Old Rats: A Microdialysis Study

Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched Environment

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