Environmental Fate of Insecticidal Plant-Incorporated Protectants from Genetically Modified Crops: Knowledge Gaps and Research Opportunities

Parker, Kimberly M.; Sander, Michael

doi:10.1021/acs.est.7b03456

Cited by 43 publications

(39 citation statements)

References 98 publications

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“…For harm to occur from dsRNA-expressing plants, NTOs must be susceptible to the dsRNA expressed by the plant and ingest it in sufficient concentrations (Christiaens et al, 2018). Exposure can occur when NTOs feed on living plant material, or consume other plant parts (e.g., pollen) or plantfed herbivores, or are exposed through plant root exudates into soil or aquatic environments (Dubelman et al, 2014;Fischer et al, 2017;Parker and Sander, 2017;Romeis et al, 2019). Once the dsRNA is ingested by the NTO, it must resist degradation in the gut, and be uptaken in sufficient quantities to activate the NTO's endogenous RNAi machinery.…”

Section: Environmental Risk Assessmentmentioning

confidence: 99%

Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective

et al. 2020

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Genetically modified plants (GMPs) intended for market release can be designed to induce "gene silencing" through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the existing risk assessment approaches for GMPs are appropriate for the risk assessment of RNAi-based GMPs or require complementary or alternative approaches. To our knowledge, at the international level, no dedicated guidelines have been developed for the risk assessment and regulation of RNAi-based GMPs, confirming that existing science-based risk assessment approaches for GMPs are generally considered suitable for RNAi-based GMPs. However, some specificities have been identified for the risk assessment of RNAi-based GMPs. Here, we report on some of these specificities as identified and addressed by the EFSA GMO Panel for the molecular characterisation, food/feed safety assessment and environmental risk assessment of RNAi-based GMPs, using the DvSnf7 dsRNA-expressing maize MON87411 as a case study.

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Section: Environmental Risk Assessmentmentioning

confidence: 99%

Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective

et al. 2020

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“…PIPs are transgenic plants that render the plant unsuitable for pest attack. Insecticidal molecules employed in PIP technology are Bt Cry proteins, toxic complex (Tc) proteins from Xenorhabdus and Photprhabdus, α-amylase inhibitors, protease from Baculovirus, double-stranded ribonucleic acid (dsRNA), and Mir1-CP from maize (Shingote et al, 2013;Maciel et al, 2014;Parker and Sander, 2017;Wei et al, 2018;Ganapathy et al, 2021).…”

Section: Definition and Categories Of Biopesticidesmentioning

confidence: 99%

Biopesticides in Sustainable Agriculture: A Critical Sustainable Development Driver Governed by Green Chemistry Principles

Fenibo¹,

Ijoma²,

Matambo³

2021

Front. Sustain. Food Syst.

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“…To force their production, the plants can be genetically modified introducing the gene acting on a specific pesticidal protein into the genetic material of the plant itself. In this way, the plant can synthesize the toxic compounds for selected pests [47].…”

Section: Plant-incorporated Protectantsmentioning

confidence: 99%

Bioremediation of Agricultural Soils Polluted with Pesticides: A Review

2021

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Pesticides are chemical compounds used to eliminate pests; among them, herbicides are compounds particularly toxic to weeds, and this property is exploited to protect the crops from unwanted plants. Pesticides are used to protect and maximize the yield and quality of crops. The excessive use of these chemicals and their persistence in the environment have generated serious problems, namely pollution of soil, water, and, to a lower extent, air, causing harmful effects to the ecosystem and along the food chain. About soil pollution, the residual concentration of pesticides is often over the limits allowed by the regulations. Where this occurs, the challenge is to reduce the amount of these chemicals and obtain agricultural soils suitable for growing ecofriendly crops. The microbial metabolism of indigenous microorganisms can be exploited for degradation since bioremediation is an ecofriendly, cost-effective, rather efficient method compared to the physical and chemical ones. Several biodegradation techniques are available, based on bacterial, fungal, or enzymatic degradation. The removal efficiencies of these processes depend on the type of pollutant and the chemical and physical conditions of the soil. The regulation on the use of pesticides is strictly connected to their environmental impacts. Nowadays, every country can adopt regulations to restrict the consumption of pesticides, prohibit the most harmful ones, and define the admissible concentrations in the soil. However, this variability implies that each country has a different perception of the toxicology of these compounds, inducing different market values of the grown crops. This review aims to give a picture of the bioremediation of soils polluted with commercial pesticides, considering the features that characterize the main and most used ones, namely their classification and their toxicity, together with some elements of legislation into force around the world.

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Environmental Fate of Insecticidal Plant-Incorporated Protectants from Genetically Modified Crops: Knowledge Gaps and Research Opportunities

Cited by 43 publications

References 98 publications

Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective

Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective

Biopesticides in Sustainable Agriculture: A Critical Sustainable Development Driver Governed by Green Chemistry Principles

Bioremediation of Agricultural Soils Polluted with Pesticides: A Review

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