Environmental factors producing autoimmune dysregulation – Chronic activation of T cells caused by silica exposure

Lee, Sai Peck; Hayashi, Hiroaki; Maeda, Megumi; Chen, Ying; Matsuzaki, Hidenori; Takei-Kumagai, Naoko; Nishimura, Yasumasa; Fujimoto, Wataru; Otsuki, Takemi

doi:10.1016/j.imbio.2011.12.009

Cited by 53 publications

(44 citation statements)

References 60 publications

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“…The silica particles are then transported to regional lymph nodes, resulting in chronic activation of T cells and triggering autoimmune reactions in susceptible patients. [48][49][50] A higher incidence of MPO-AAV was reported after the Kobe earthquake in Japan, possibly related to increased silica exposure. 51 After closure of the last coal mine in the region of Maastricht, the Netherlands, MPO-AAV diagnoses appeared to decrease compared with the number of PR3-AAV diagnoses.…”

Section: Etiologymentioning

confidence: 99%

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Hilhorst

Paassen

Tervaert

2015

Journal of the American Society of Nephrology

172

137

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In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV) and MPO-AAV described in the past have been supplemented during the last decade. In this review, we discuss the differences between these two small-vessel vasculitides, focusing especially on possible etiologic and pathophysiologic differences. PR3-AAV is more common in northern parts of the world, whereas MPO-AAV is more common in southern regions of Europe, Asia, and the Pacific, with the exception of New Zealand and Australia. A genetic contribution has been extensively studied, and there is a high prevalence of the HLA-DPB1*04:01 allele in patients with PR3-AAV as opposed to patients with MPO-AAV and/or healthy controls. Histologically, MPO-AAV and PR3-AAV are similar but show qualitative differences when analyzed carefully. Clinically, both serotypes are difficult to distinguish, but quantitative differences are present. More organs are affected in PR3-AAV, whereas renal limited vasculitis occurs more often in patients with MPO-AAV. For future clinical trials, we advocate classifying patients by ANCA serotype as opposed to the traditional disease type classification.

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Section: Etiologymentioning

confidence: 99%

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Hilhorst

Paassen

Tervaert

2015

Journal of the American Society of Nephrology

172

137

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“…2f, the overall findings indicate that an unbalance (decrease of Treg and increase of Tresp) may be present in the peripheral blood of SIL, and this unbalance may be the cause of subsequent autoimmune diseases in SIL [37,38,[52][53][54][55][56]. In the future, the effects of silica particles on Th17 cells, which are considered to play an important role in the development of autoimmune disease [57][58][59], should be analyzed to better understand the comprehensive effects of silica particles on immune dysregulation, particularly impairment of autoimmunity.…”

Section: Effects On Nk Cellsmentioning

confidence: 88%

“…On the other hand, we reported that peripheral T helper cells in SIL are assumed to have two fractions [1,2,37,38]. One is the fraction in which T cells possess resistance to CD95/Fas-mediated apoptosis by over-production of extracellular inhibitors such as the soluble form of Fas molecules (one of the typical alternatively spliced variants of Fas molecule and known to be elevated in the serum of various autoimmune diseases [39,40]), and overexpression of decoy receptor 3 (DcR3) [41] and other variant messages of Fas molecules [42].…”

Section: Effects On Nk Cellsmentioning

confidence: 99%

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Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Otsuki

Matsuzaki

Lee

et al. 2015

Environ Health Prev Med

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Among the various scientific fields covered in the area of hygiene such as environmental medicine, epidemiology, public health and preventive medicine, we are investigating the immunological effects of fibrous and particulate substances in the environment and work surroundings, such as asbestos fibers and silica particles. In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we will summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (

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“…However, silica particles, comprising Si and O 2 and which represent the core components of asbestos fibers chemically, cause alteration of immune cells in various autoimmune diseases [22][23][24]. Although the physiological effects caused by silica and asbestos differ, including those produced by fibers and particles, asbestos fibers may influence the various circulating immune cells in a manner similar to silica particles.…”

Section: Introductionmentioning

confidence: 99%

416 Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos

Otsuki

Lee

Matsuzaki

et al. 2018

Allergy and Immunotoxicology

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The immunological effects of asbestos exposure on various lymphocytes such as the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were investigated. Results show that asbestos exposure impairs antitumor immunity through enhancement of regulatory T cell function and volume, reduction of CXCR3 chemokine receptor in responder CD4+ T helper cells, and impairment of the killing activities of CD8+ cytotoxic T lymphocytes (CTL) and NK cells. These findings were used to explore biological markers associated with asbestos exposure and asbestos-induced cancers and suggested the usefulness of serum/plasma IL-10 and TGF-β, surface CXCR3 expression in Tresp, the secreting potential of IFN-γ in Tresp, intracellular perforin level in CTL, and surface expression NKp46 in NK cells. Although other unexplored cytokines in serum/plasma and molecules in these immunological cells, including Th17, should be investigated by experimental procedures in addition to a comprehensive analysis of screening methods, biomarkers based on immunological alterations may be helpful in clinical situations to screen the high-risk population exposed to asbestos and susceptible to asbestos-related cancers such as mesothelioma.

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Environmental factors producing autoimmune dysregulation – Chronic activation of T cells caused by silica exposure

Cited by 53 publications

References 60 publications

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

416 Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos

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