Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: Ecogenetic studies in a Mediterranean Spanish population

Corella, Dolores; n, Marisa Guill; iz, Carmen S; s, Olga Portol; Martínez-Sabater, Antonio; Cortina, Silvia; Folch, J.; ́lez, J. Gonza; Ordovas, José M.

doi:10.1053/meta.2001.24867

Cited by 71 publications

(53 citation statements)

References 36 publications

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“…Only adolescents with adequate aerobic fitness carrying the ε3 and ε4 alleles presented a lower probability (20% to 19%) of low HDL cholesterol than ε2 carriers (Table 3). Lower HDL cholesterol concentrations have been observed in physically active men with ε2 allele when compared to those with ε4 allele (Corella et al, 2001). Similar concentrations have been detected 11.0%) (Bernstein et al, 2002) and French (8.0%, 80.0%, and 12.0%) (Marques-Vidal et al,2003) population.…”

Section: Discussionsupporting

confidence: 72%

“…Higher concentrations of HDL have been observed in physically active men with ε4 allele when compared to those with ε2 allele. In contrast, in inactive individuals higher concentrations of this lipoprotein were found among those carrying ε2 allele (Corella et al, 2001). In addition, inactive individuals, but not physically active individuals, carrying ε4 allele were found to have higher LDL concentrations than carriers of the other alleles (Pisciotta et al, 2003).…”

Section: Introductionmentioning

confidence: 86%

“…The major alleles are called epsilon two (ε2), three (ε3) and four (ε4) and are important modulators of serum lipemia. In general, individuals carrying the ε2 allele present lower serum concentrations of TC and LDL (Alvim et al, 2010;Bernstein et al, 2002;Corella et al, 2001;França, Alves, & Hutz, 2004;Nghiem et al, 2004) whereas the opposite is observed for those carrying ε4 allele (Bernstein et al, 2002;Corella et al, 2001; Medina-Urrutia, Cardoso-Saldaña, ZamoraGonzález, Liria, & Posadas-Romero, 2004;Nascimento et al, 2009). The association between APOE alleles and lipemia seems to be influenced by physical activity levels.…”

Section: Introductionmentioning

confidence: 99%

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Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Glaner¹,

Nascimento²,

Nóbrega³

2014

Motriz: rev. educ. fis.

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Abstract-The purpose of this study was to analyze the association between APOE alleles and serum lipemia in adolescents with low and adequate aerobic fitness. The sample was comprised of 105 boys and 151 girls (49% and 46% from rural area) of European ancestry, aged 11 to 17 years, and classified according to: 1) APOE genotype: group ε2 (ε2/3+ε2/2), ε3 (ε3/3), and ε4 (ε3/4+ε4/4); 2) aerobic fitness: adequate or low; 3) serum lipemia: elevated total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides, and low high-density lipoprotein (HDL). The results showed that aerobic fitness modulates the association between APOE alleles and serum lipemia in adolescents, suggesting that adequate aerobic fitness levels exert a greater effect of reducing TC and LDL in ε2 carriers, as well as of increasing HDL and reducing triglycerides in ε3 and ε4 carriers. Keywords: apolipoproteins E, physical endurance, adolescent health, lipoproteinsResumo-"Aptidão física aeróbica modula a associação entre genótipos da APOE e lipemia sérica em adolescentes." O objetivo deste estudo foi analisar a associação entre os alelos da APOE e a lipemia sérica em adolescentes com baixa e adequada aptidão aeróbia. Amostra: 105 rapazes(49% da área rural) e 151 moças (46% da área rural) descendentes de europeus, com idade de 11 a 17 anos, classificados de acordo com 1) genótipo da APOE: grupo ε2 (ε2/3+ε2/2), ε3 (ε3/3), e ε4 (ε3/4+ε4/4); 2) aptidão aeróbia: adequada ou baixa; 3) lipemia sérica: elevados colesterol total (CT), lipoproteína de baixa densidade (LDL) e triglicérides, e baixa lipoproteína de alta densidade (HDL). Os resultados demonstram que a aptidão aeróbia modula a associação dos alelos da APOE com a lipemia sérica de adolescentes, sugerindo que níveis adequados de aptidão aeróbia têm efeito maior em reduzir CT e LDL elevados nos portadores do alelo ε2, bem como o efeito maior em aumentar HDL e reduzir triglicerídeos naqueles com ε3 e ε4. Palavras-chave: apolipoproteína E, resistência física, saúde do adolescente, lipoproteínasResumen-"La condición física aeróbica modula la asociación entre los genotipos APOE y lipemia sérico en adolescentes." El objetivo fue analizar la asociación entre los alelos APOE y la lipemia sérica en adolescentes con baja y adecuada condición aeróbica. La muestra fue composta de 105 niños (49% de las zonas rurales) y 151 niñas (46% de las zonas rurales) de origen europeo, con edades entre 11-17 años, clasificados de acuerdo con 1) el genotipo APOE: grupo ε2 (ε2 / 3 + ε2 / 2), ε3 (ε3 / 3), y ε4 (ε3 / ε4 + 4/4); 2) la condición aeróbica: adecuada o baja; 3) suero lipémico: colesterol (CT), lipoproteínas de baja densidad (LDL) y los triglicéridos elevados y lipoproteínas de alta densidad (HDL) bajo. Los resultados muestran que la capacidad aeróbica modula la asociación de los alelos APOE con la lipemia de los adolescentes, lo que sugiere que niveles adecuados de capacidad aeróbica tienen mayor efecto en la reducción de CT y LDL elevados en el alelo ε2, y el mayor efecto para aumentar el HDL y la reducci...

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Glaner¹,

Nascimento²,

Nóbrega³

2014

Motriz: rev. educ. fis.

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“…El alelo ε2 se asoció con concentraciones bajas de colesterol total, C-LDL y ApoB-100 y el alelo ε4 mostró las concentraciones más altas de estas variables. El alelo ε4 ha sido asociado con un incremento de enfermedad coronaria pero su efecto puede variar de acuerdo con factores como el sexo, estilo de vida, etnia y ambiente (7,30).…”

Section: Discussionunclassified

Polimorfismo genético de la apolipoproteína E en un grupo de escolares del centro-oriente colombiano: comparación con las concentraciones plasmáticas de lípidos y apolipoproteínas

et al. 2007

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Introducción. Estudios mundiales han demostrado la contribución de los alelos de la apolipoproteína E en las variaciones de los lípidos y las apolipoproteínas. Objetivo. Determinar la frecuencia alélica y genotípica de la apolipoproteína E y su asociación con los lípidos y apolipoproteínas en escolares de la región centro-oriental de Colombia. Materiales y métodos. El tamaño de la muestra fue de 691 escolares entre los 5 y 15 años, de los departamentos de Cundinamarca, Boyacá, Meta, Santander y Norte de Santander. Los genotipos de la apolipoproteína E se identificaron por reacción en cadena de la polimerasapolimorfismo de longitud del fragmento de restricción. Se analizaron las variables lipídicas de colesterol total, colesterol HDL, colesterol LDL, triglicéridos y colesterol VLDL, apolipoproteína A-I y apolipoproteína B-100. Resultados. Las frecuencias de los alelos ε2, ε3 y ε4 fueron 0,04, 0,86 y 0,08, respectivamente. El grupo E4 (E4/3-E4/4) comparado con el grupo E2 (E3/2-E2/2) presentó las concentraciones plasmáticas más altas de colesterol total, colesterol LDL y apolipoproteína B-100 (p=0,014, 0,001 y 0,000, respectivamente), lo mismo ocurre al comparar el grupo E3/3 con el E2 (p=0,015, 0,002 y 0,002, respectivamente); la influencia del polimorfismo de la apolipoproteína E fue mayor en las niñas. Conclusiones. La asociación del alelo e4 con niveles más altos de colesterol total, colesterol LDL y apolipoproteína B-100 muestra la importancia de realizar otros estudios sobre el polimorfismo de la apolipoproteína E, su interacción con otros genes, estilos de vida y factores de riesgo y su posible contribución para el desarrollo de enfermedad cardiovascular.

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“…For example, exercise (71), education (72), and vitamin D status (73) have all been shown to impact the effects of APOE genotype on cognitive functions. Also, lifestyle factors such as alcohol consumption and physical activity were found to significantly interact with APOE genotype in determining plasma lipid concentrations in a gender-specific manner (74). Given that epigenetic mechanisms seem to bridge the gap between genetics and environment as they pertain to disease, it is plausible that epigenetic mechanisms underlie the above observations.…”

Section: Environmental Stimuli That Influence Apoementioning

confidence: 99%

Epigenetic considerations of the APOE gene

Foraker

2015

Biomolecular Concepts

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Abstract:The apolipoprotein E (APOE) gene is robustly linked with numerous physiological conditions, including healthy aging, altered cardiovascular fitness, and cognitive function. These connections have been established primarily by phenotype-genotype association studies using APOE's three common genetic variants (ε2, ε3, and ε4). These variants encode for the three apoE protein isoforms (E2, E3, and E4), which have slightly different structures and, consequently, distinct functions in lipid metabolism. However, the differential lipid binding and transferring properties of these isoforms cannot fully explain the association of APOE with such a wide range of physiological phenotypes. One potential explanation for APOE's pleiotropic roles may lie in its unique epigenetic properties. In this article, we present a brief review of the APOE gene and protein, its disease associations, and epigenetic components, with a focus on DNA methylation. We close with a discussion of the prospective epigenetic implications of APOE in disease.

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Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: Ecogenetic studies in a Mediterranean Spanish population

Cited by 71 publications

References 36 publications

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Polimorfismo genético de la apolipoproteína E en un grupo de escolares del centro-oriente colombiano: comparación con las concentraciones plasmáticas de lípidos y apolipoproteínas

Epigenetic considerations of the APOE gene

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