Environmental exposure to manganese and motor function of children in Mexico

Hernández-Bonilla, David; Schilmann, Astrid; Montes, Sergio; Rodríguez-Agudelo, Y.; Rodríguez-Dozál, Sandra; Solís-Vivanco, Rodolfo; Rı́os, Camilo; Riojas-Rodríguez, Horacio

doi:10.1016/j.neuro.2011.07.010

Cited by 72 publications

(59 citation statements)

References 36 publications

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“…This study also found a positive association between early postnatal enamel Mn levels and teacher-reported scores of externalizing problems at ages 6–7 and 8–9 years. Unlike numerous cross-sectional studies of school-age children that reported negative associations between Mn levels and cognition (Bouchard et al 2011b; He et al 1994; Hernandez-Bonilla et al 2011; Kim et al 2009; Lucchini et al 2012; Menezes-Filho et al 2011; Riojas-Rodriguez et al 2010; Torres-Agustin et al 2013; Wasserman et al 2006), a cohort study of 247 French children did not find significant adverse associations of maternal and child Mn levels at delivery with cognitive abilities assessed at ages 3 and 6 years (Takser et al 2003), while we observed beneficial associations among boys.…”

Section: Discussioncontrasting

confidence: 99%

“…Previous cross-sectional studies have reported stronger negative associations of Mn levels with behavior, cognitive, memory, and motor outcomes for girls than for boys (Bouchard et al 2011a; Hernandez-Bonilla et al 2011; Menezes-Filho et al 2013; Riojas-Rodriguez et al 2010; Torres-Agustin et al 2013). Our study did not show negative associations between prenatal or postnatal dentine Mn levels and these outcomes for girls, but instead we observed several positive and significant associations for boys.…”

Section: Discussionmentioning

confidence: 89%

“…Postnatal Mn exposure has been associated with poor language development in toddler boys (Rink et al 2014), and behavioral problems in school-aged boys and girls (Ericson et al 2007). Studies of school-aged children and adolescents (6–14 year olds) have linked elevated Mn levels in drinking water, blood, and hair samples with oppositional behavior and hyperactivity (Bouchard et al 2007), impaired cognitive abilities (Bouchard et al 2011b; Kim et al 2009; Menezes-Filho et al 2011; Riojas-Rodriguez et al 2010; Wasserman et al 2006), and poor memory (He et al 1994; Torres-Agustin et al 2013), motor coordination (He et al 1994; Hernandez-Bonilla et al 2011; Lucchini et al 2012), and visuoperceptive speed (He et al 1994; Zhang et al 1995). To date, only one epidemiologic study has assessed exposure to Mn both prenatally and postnatally (Ericson et al 2007).…”

Section: Introduction1mentioning

confidence: 99%

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Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort

Mora

Arora

Harley

et al. 2015

Environment International

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Background Numerous cross-sectional studies of school-age children have observed that exposure to manganese (Mn) adversely affects neurodevelopment. However, few prospective studies have looked at the effects of both prenatal and postnatal Mn exposure on child neurodevelopment. Methods We measured Mn levels in prenatal and early postnatal dentine of shed teeth and examined their association with behavior, cognition, memory, and motor functioning in 248 children aged 7, 9, and/or 10.5 years living near agricultural fields treated with Mn-containing fungicides in California. We used generalized linear models and generalized additive models to test for linear and nonlinear associations, and generalized estimating equation models to assess longitudinal effects. Results We observed that higher prenatal and early postnatal Mn levels in dentine of deciduous teeth were adversely associated with behavioral outcomes, namely internalizing, externalizing, and hyperactivity problems, in boys and girls at 7 and 10.5 years. In contrast, higher Mn levels in prenatal and postnatal dentine were associated with better memory abilities at ages 9 and 10.5, and better cognitive and motor outcomes at ages 7 and 10.5 years, among boys only. Higher prenatal dentine Mn levels were also associated with poorer visuospatial memory outcomes at 9 years and worse cognitive scores at 7 and 10.5 years in children with higher prenatal lead levels (≥0.8 μg/dL). All these associations were linear and were consistent with findings from longitudinal analyses. Conclusions We observed that higher prenatal and early postnatal Mn levels measured in dentine of deciduous teeth, a novel biomarker that provides reliable information on the developmental timing of exposures to Mn, were associated with poorer behavioral outcomes in school-age boys and girls and better motor function, memory, and/or cognitive abilities in school-age boys. Additional research is needed to understand the inconsistencies in the neurodevelopmental findings across studies and the degree to which differences may be associated with different Mn exposure pathways and biomarkers.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 89%

Section: Introduction1mentioning

confidence: 99%

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Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort

Mora

Arora

Harley

et al. 2015

Environment International

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“…77,78 Whether there is a correlation with the recent epidemiological studies showing associations between elevated dietary Mn exposure and neurobehavioral and neurocognitive deficits in children has to be elucidated in further studies. [79][80][81] …”

Section: Consequences Of Dna Damage Induced By Manganesementioning

confidence: 99%

DNA Damage Induced by Manganese

Bornhorst¹,

Schwerdtle²

2014

Manganese in Health and Disease

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This chapter summarizes the current studies on the genotoxic potential of manganese (Mn) and is thereby points out that the knowledge gained up to now is quite equivocal. Besides reviewing the current literature on Mn-induced DNA damage on a chromosomal as well as a DNA level, possible underlying mechanisms, including disturbances of DNA replication/DNA polymerases as well as DNA damage response pathways, are discussed. Finally, this chapter gives a brief overview of the possible consequences of DNA damage induced by manganese.

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“…A recent study by Lucchini et al, reported BMn and HMn levels were positively associated with increased resting tremor intensity. (53) Two other studies by Hernandez-Bonilla et al,(54) and Takser et al,(55) reported children exposed to Mn performed poorly on manual dexterity, fine motor coordination, and hand skill tests. Children in our cohort showed a characteristic non-linear association between BMn levels and fine motor precision, manual dexterity, balance, running speed, and strength, suggesting that both low and high manganese levels may have adverse effects on neuromotor function in children.…”

Section: Discussionmentioning

confidence: 92%

Secondhand Tobacco Smoke Exposure and Neuromotor Function in Rural Children

Yeramaneni¹,

Dietrich²,

Yolton³

et al. 2015

The Journal of Pediatrics

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Objectives To investigate the relationship between secondhand tobacco smoke (SHS) exposure and neuromotor function in children. Study design We studied 404 children aged 7–9 years who were exposed to SHS and other environmental neurotoxicants. Parent reported smoking habits, and serum cotinine levels were measured in children to determine SHS exposure. Halstead-Reitan Finger Oscillation Test (HRFOT), Purdue Grooved Pegboard Test – Kiddie version (PGPT), and Bruininks-Oseretsky Test of Motor Proficiency 2-Short form (BOT-2) were used to assess neuromotor function. Multivariable regression models that accounted for potential confounders were used to evaluate the associations. Results Approximately 50% of the children were exposed to SHS based on serum cotinine measures. Exposure to SHS was significantly associated with motor impairment in children, including diminished visuo-motor coordination (p=0.01), fine motor integration (p=0.01), balance (p=0.02), and strength (p=0.04) after adjusting for exposures to lead and manganese, age, sex, body mass index, measures of cognitive abilities of parents, parental education, and quality of home environment Conclusions We conclude that SHS is a neurotoxicant that may be associated with impaired childhood neuromotor function.

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Environmental exposure to manganese and motor function of children in Mexico

Cited by 72 publications

References 36 publications

Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort

Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort

DNA Damage Induced by Manganese

Secondhand Tobacco Smoke Exposure and Neuromotor Function in Rural Children

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