Environmental enrichment protects spatial learning and hippocampal neurons from the long-lasting effects of protein malnutrition early in life

Soares, Roberto O.; Horiquini-Barbosa, Everton; Almeida, Sebastião de Sousa; Lachat, João José

doi:10.1016/j.bbr.2017.08.012

Cited by 11 publications

(4 citation statements)

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“…Previous studies suggest that EE produces a neuroprotective effect on young and adult rodents, improving the branch number and length of dendrites, synaptic plasticity, neurogenesis, and spatial memory capacity ( Nithianantharajah and Hannan, 2006 ; Wolf et al, 2006 ; Lonetti et al, 2010 ; Williamson et al, 2012 ; Scholz et al, 2015 ; Bechard et al, 2016 ; Garthe et al, 2016 ; He et al, 2017 ; Soares et al, 2017 ). Our previous studies have also shown that 1-month-old mice raised in an EE for 8 weeks exhibit better spatial and social memory-related behavioral performances than those housed in a standard environment ( Cao et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice

Wang

Cao

et al. 2018

International Journal of Neuropsychopharmacology

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BackgroundSocial isolation in the elderly is one of the principal health risks in an aging society. Physical environmental enrichment is shown to improve sensory, cognitive, and motor functions, but it is unknown whether environmental enrichment can protect against brain impairments caused by social isolation.MethodsEighteen-month-old mice were housed, either grouped or isolated, in a standard or enriched environment for 2 months, respectively. Behavioral tests were performed to evaluate cognitive functional and social interaction ability. Synaptic protein levels, myelination, neuroinflammation, brain derived neurotrophic factor, and NOD-like receptor protein 3 inflammasome signaling pathways were examined in the medial prefrontal cortex and hippocampus.ResultsIsolated aged mice exhibited declines in spatial memory and social memory compared with age-matched littermates living within group housing. The aforementioned memory malfunctions were mitigated in isolated aged mice that were housed in a large cage with a running wheel and novel toys. Enriched housing prevented synaptic protein loss, myelination defects, and downregulation of brain derived neurotrophic factor, while also increasing interleukin 1 beta and tumor necrosis factor alpha in the medial prefrontal cortex and hippocampus of isolated mice. In addition, activation of glial cells and NOD-like receptor protein 3 inflammasomes was partially ameliorated in the hippocampus of isolated mice treated with physical environmental enrichment.ConclusionsThese results suggest that an enriched physical environment program may serve as a nonpharmacological intervention candidate to help maintain healthy brain function of elderly people living alone.

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Section: Discussionmentioning

confidence: 99%

Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice

Wang

Cao

et al. 2018

International Journal of Neuropsychopharmacology

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“…Previously, studies have found that housing lab animals in EE had beneficial effects on their brain structure and behaviors. The main findings regarding the effects of EE on the brain can be summarized as improved spatial learning and memory consolidation [ 17 , 18 , 19 ], reduction of behaviors associated with depression and anxiety [ 20 , 21 , 22 , 23 ], and reduction in age-related memory impairment [ 24 , 25 ]. Initial studies investigating the effects of EE in preclinical models of neurodegenerative diseases were conducted in the early 2000s, particularly in Huntington’s disease and AD.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

2022

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Environmental enrichment (EE) is an environmental paradigm encompassing sensory, cognitive, and physical stimulation at a heightened level. Previous studies have reported the beneficial effects of EE in the brain, particularly in the hippocampus. EE improves cognitive function as well as ameliorates depressive and anxiety-like behaviors, making it a potentially effective neuroprotective strategy against neurodegenerative diseases such as Alzheimer’s disease (AD). Here, we summarize the current evidence for EE as a neuroprotective strategy as well as the potential molecular pathways that can explain the effects of EE from a biochemical perspective using animal models. The effectiveness of EE in enhancing brain activity against neurodegeneration is explored with a view to differences present in early and late life EE exposure, with its potential application in human being discussed. We discuss EE as one of the non pharmacological approaches in preventing or delaying the onset of AD for future research.

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“…Em seguida os ratos foram separados em dois grupos, sendo o primeiro grupo tratado com Se-Met 6g/ml em água potável por 12 semanas, enquanto o segundo grupo recebeu água potável normal. Semelhante aos artigos 6 17 e 718 , os ratos do artigo 8 foram submetidos a um teste labirinto aquático que consiste em medir o tempo necessário para os ratos encontrarem a plataforma de saída35 . Deste modo, a eficácia terapêutica da Se-Met foi constatada por meio da melhora observada no grupo tratado, com uma latência menor para encontrar a plataforma durante os treinos ou após 24h e 72h após a finalização do treino.Após a coleta dos testes comportamentais, os ratos foram eutanasiados e seus cérebros foram removidos.…”

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O O consumo de selênio e sua relação com a manutenção da função cognitiva: uma revisão sistemática sobre humanos e animais

Nogueira¹,

Ducatti²,

Horiquini-Barbosa³

2020

Rev Neurocienc

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Introdução. O indivíduo é considerado idoso a partir dos 60 anos e o processo de envelhecimento é caracterizado por alterações morfológicas, fisiológicas, bioquímicas e psicológicas que dependem do modo de vida. O envelhecimento resulta do acúmulo de danos moleculares e celulares ao longo da vida, levando a uma diminuição gradual da capacidade física e mental, e maiores chances do desenvolvimento de patologias a exemplo do declínio da função cognitiva. Estudos apontam que o consumo adequado de alimentos que contém selênio atua na inibição da produção de radicais livres, reduzindo os danos causados pelo estresse oxidativo. Objetivo. Deste modo, objetivo deste estudo foi investigar a relação entre selênio e a manutenção da função cognitiva. Método. Este estudo se trata de uma revisão sistemática da literatura, realizada nas bases eletrônicas de dados PubMed, MedLine e Lilacs, utilizando a combinação de palavras-chave específicas. Resultados. A busca resultou em 270 estudos, contudo, aplicado os critérios de inclusão e exclusão, selecionou-se oito artigos. Conclusão. Segundo os artigos selecionados, o consumo de selênio pode melhorar o sistema antioxidante e assim, apresentar efeitos positivos sobre a função cognitiva em idosos humanos. Os estudos com animais mostraram que a suplementação por selênio foi capaz de diminuir o estresse oxidativo e melhorar o aprendizado e o funcionamento da memória em testes comportamentais específicos. Conclusão. Em síntese, os estudos discutidos neste trabalho mostram uma alta relação do consumo de selênio e a melhora do desempenho cognitivo, tanto em humanos, quanto em animais.

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Environmental enrichment protects spatial learning and hippocampal neurons from the long-lasting effects of protein malnutrition early in life

Cited by 11 publications

References 61 publications

Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice

Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

O O consumo de selênio e sua relação com a manutenção da função cognitiva: uma revisão sistemática sobre humanos e animais

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