Environmental Determinants of Lung Aging

Green, Francis H. Y.; Pinkerton, Kent E.

doi:10.1016/b978-0-12-799941-8.00027-4

Cited by 3 publications

(1 citation statement)

References 231 publications

(236 reference statements)

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“…This progressive deterioration is particularly notable in the lung; age-related changes affect immune responses and antioxidant defenses in addition to altering airway receptor activity (Wang et al, 2010). Structural changes also can occur, impairing lung compliance and increasing work associated with breathing (Green and Pinkerton, 2004). These age-related changes are accelerated by pathologic manifestations of CVD, which is prevalent among mature adult populations (Bentayeb et al, 2012).…”

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confidence: 99%

Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease

Wong

Walby

Wilson

et al. 2018

Toxicological Sciences

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Particulate matter (PM) and ozone (O3) are dominant air pollutants that contribute to development and exacerbation of multiple cardiopulmonary diseases. Mature adults with cardiovascular disease (CVD) are particularly susceptible to air pollution-related cardiopulmonary morbidities and mortalities. The aim was to investigate the biologic potency of ultrafine particulate matter (UFPM) combined with O3 in the lungs of mature adult normotensive and spontaneously hypertensive (SH) Wistar-Kyoto rats. Conscious, mature adult male normal Wistar-Kyoto (NW) and SH rats were exposed to one of the following atmospheres: filtered air (FA); UFPM (∼ 250 μg/m3); O3 (1.0 ppm); or UFPM + O3 (∼ 250 μg/m3 + 1.0 ppm) combined for 6 h, followed by an 8 h FA recovery period. Lung sections were evaluated for lesions in the large airways, terminal bronchiolar/alveolar duct regions, alveolar parenchyma, and vasculature. NW and SH rats were similarly affected by the combined-pollutant exposure, displaying severe injury in both large and small airways. SH rats were particularly susceptible to O3 exposure, exhibiting increased injury scores in terminal bronchioles and epithelial degeneration in large airways. UFPM-exposure groups had minimal histologic changes. The chemical composition of UFPM was altered by the addition of O3, indicating that ozonolysis promoted compound degradation. O3 increased the biologic potency of UFPM, resulting in greater lung injury following exposure. Pathologic manifestations of CVD may confer susceptibility to air pollution by impairing normal lung defenses and responses to exposure.

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confidence: 99%

Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease

Wong

Walby

Wilson

et al. 2018

Toxicological Sciences

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The Aging Human Lung: Age-Associated Changes in Structure and Function

Meyer¹

2006

Handbook of Models for Human Aging

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Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia

Tadevosyan

Kirakosyan

Muradyan

et al. 2021

Journal of Health and Pollution

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Background. Many studies have investigated the effects of organochlorine pesticides (OCPs) on adverse health outcomes. However, studies addressing the link between respiratory health and OCPs are limited. Organochlorine pesticides are stable compounds and belong to the class of endocrine disrupting chemicals that represent a threat to global health. Objectives. The aim of the present study was to examine the association between respiratory morbidity and environmental exposure to OCPs in selected regions in Armenia. Methods. The study was carried out in Lori and Gegharkunik provinces/marzes. The prevalence rate (per 100 000 population) and the average chronological indicators (ACh) for all respiratory diseases and asthma were calculated. Concentrations of OCPs (γ-hexachlorocyclohexane (γ-HCH), dichloro-diphenyl-trichloroethane [DDT], dichlorodiphenyldichloroethylene (DDE) and dichloro-diphenyl-dichloroethane (DDD)) were determined in soil and plant product samples and the average annual total concentration (AATC) of OCPs (γ-HCH + 4,4′-DDT + 4,4′-DDE+4,4′-DDD) was calculated. Results. The ACI for all respiratory diseases showed a growth tendency in areas of Gegharkunik province ranging from 14.2 to 20.9% and an increase in asthma ranging from 9.4% to 174.6%. The highest levels of AATC of OCPs were found in soil sampled in Gegharkunik province: 9.48 ± 1.11 μg/kg and 8.10 ± 1.05 μg/kg and these levels differed significantly from those in Lori (p=0.01–0.0007). The AATC of OCPs in plant products from Gegharkunik was also statistically higher: 1.83±0.13 μg/kg, in comparison with that of Lori province 1.31±0.09 μg/kg (p = 0.001 – 0.0000). Conclusions. The results indicate that the increased tendency of respiratory diseases and asthma could be related to OCP residues found in soil and plant products in Gegharkunik province. However, the role of OCPs should not be ignored. Further research is needed to study OCP contamination dynamics and clarify the role of OCPs in respiratory morbidity. Competing Interests. The authors declare no competing financial interests.

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Environmental Determinants of Lung Aging

Cited by 3 publications

References 231 publications

Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease

Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease

The Aging Human Lung: Age-Associated Changes in Structure and Function

Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia

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