Environmental Contamination with Hazardous Drugs in Quebec Hospitals

Bussières, Jean-François; Tanguay, Cynthia; Touzin, Karine; Langlois, Éric; Lefebvre, Michel

doi:10.4212/cjhp.v65i6.1190

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…For calculations, concentrations that fell between the limit of detection and the limit of quantification were assigned a value corresponding to the limit of quantification divided by 2, 14 and concentrations that fell below the limit of detection were assigned a value corresponding to the limit of detection divided by 2. 15 Results from the hospitals that participated in the 3 earlier studies [10][11][12] and the current study were used for comparisons over time.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] Nineteen hospitals participated in all 4 studies. There was no difference in surface contamination between the 19 centres that participated in all 4 studies and the 51 centres that participated in the 2014 study (Figure 2).…”

Section: Trends From 2008-2010 To 2014mentioning

confidence: 99%

“…These sites were identical with those targeted in the [2008][2009][2010]2012, and 2013 studies. [10][11][12] Each participating hospital was given a description and photographs of the standardized sampling sites. The photographs provided were taken at the investigators' hospital.…”

Section: Sampling Techniquementioning

confidence: 99%

“…[10][11][12] Twelve standardized measurement sites, 6 in pharmacy areas and 6 in patient care areas, were selected for sampling (Table 1). These sites were identical with those targeted in the [2008][2009][2010]2012, and 2013 studies.…”

Section: Sampling Techniquementioning

confidence: 99%

“…[10][11][12] For a more recent investigation, reported here, the scope of study was expanded to include Canadian centres outside Quebec. The aim of this study was to monitor environmental contamination with cyclophosphamide, ifosfamide, and methotrexate in oncology pharmacy and patient care areas in Canadian hospitals.…”

Section: Introductionmentioning

confidence: 99%

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Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

Janes

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Caron³

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Section: Discussionmentioning

confidence: 99%

Section: Trends From 2008-2010 To 2014mentioning

confidence: 99%

Section: Sampling Techniquementioning

confidence: 99%

Section: Sampling Techniquementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

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Guidelines in Practice: Medication Safety

Speth

2023

AORN Journal

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Medication errors are preventable events that health care professionals, consumers, and medication manufacturers report to the US Food and Drug Administration. The agency receives more than 100,000 medication‐related reports each year, and some reports involve patient death. A variety of sources provide perioperative nurses with information on interventions and practices to prevent medication errors, including the US Pharmacopeia, The Joint Commission, medication manufacturers’ instructions for use, safety data sheets, and the updated AORN “Guideline for medication safety.” This article provides an overview of the guideline and discusses recommendations for organizational oversight, procurement and storage, retrieval and preparation, labeling, and hazardous medications. It also includes a scenario that illustrates perioperative nursing practices for administering an antineoplastic medication intraoperatively. Perioperative nurses should review the guideline in its entirety and implement recommendations in operative or procedural settings.

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Environmental monitoring by surface sampling for cytotoxics: a review

Marie

Curti

Roche

et al. 2017

Environ Monit Assess

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Environmental monitoring is usually conducted by surface sampling to detect and quantify the presence of cytotoxic drugs after their reconstitution and administration. This technique reveals the origins of residual contamination and is an important component in order to protect healthcare workers from the potential risk of occupational exposure. The aim of this work is to compare various techniques and results of surface sampling for cytotoxics. For each technique, sample processing methods and their analysis were compared from literature data. Sampling is often performed by the wiping technique. After treatment, various single or multicompound technical analyses are used, in particular liquid or gas chromatography involving different detection methods: ultraviolet, mass spectrometry, plasma torch, and voltammetry. Some methods are validated to ensure reliability. Despite published guidelines and the use of isolator technology for the preparation of cytotoxic drugs, workplace contamination persists, leading to chemotherapeutic agents' exposure of healthcare workers. Efforts need to be maintained with particular emphasis on harmonization and on determining alert level for cytotoxic contamination.

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Environmental Contamination with Hazardous Drugs in Quebec Hospitals

Cited by 17 publications

References 23 publications

Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

Guidelines in Practice: Medication Safety

Environmental monitoring by surface sampling for cytotoxics: a review

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