Environmental chronic exposure to metals and effects on attention and executive function in the general population

Rafiee, Ata; Delgado-Saborit, Juana María; Sly, Peter D.; Quémerais, Bernadette; Hashemi, Fallah; Akbari, Sadaf; Hoseini, Mohammad

doi:10.1016/j.scitotenv.2019.135911

Cited by 42 publications

(29 citation statements)

References 121 publications

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“…6 Another findings indicated the Hg level in hair was significantly associated with declined participants' cognitive performance scores in attention and executive function (p < 0.05). 7 An identification of functional polymorphisms as genetic susceptibility factors to mercury-associated health outcomes is important as a very careful human risk assessment. A crucial group of proteins that plays a major role in mercury homeostasis, metal detoxification, and the cellular redox state is the metallothioneins (MTs).…”

Section: Introductionmentioning

confidence: 99%

“…Our results supported that increasing blood mercury levels were associated with inverse cognitive performance comparable to previous study that found mercury levels in hair had an impact on attention, executive function, mental flexibility and cognitive efficiency. 7 The mechanism by which mercury induces neurological damage is still unclear. Proposed mechanisms of mercury-mediated neurotoxicity include 1) the depletion of glutathione content as a result of interactions of mercury with sulfhydryl groups, leading to inhibition of glutathione reductase and glutathione peroxidase activities; 2) mercury can increase cellular ROS generation, resulting in damage to the mitochondrial respiratory chain, altered mitochondrial membrane permeability, and disruption of Ca2+ homeostasis.…”

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confidence: 99%

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Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)

Sirivarasai¹,

Chaisungnern²,

Panpunuan³

et al. 2021

NDT

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Purpose: Many age-related structural and functional changes in the brain have important consequences. Long-term exposure to mercury and the impact of functional polymorphisms of metal-regulating proteins such as metallothioneins (MTs) can result in neurologicalneurobehavioral effects in elderly individuals. Therefore, the aims of this study are to examine the associations between biomarkers of mercury exposure and cognitive impairment and to investigate the effect of the rs8052394 single nucleotide polymorphism (SNP) of the potential modifier gene MT1A on different domains of the Montreal Cognitive Assessment (MoCA). Materials and Methods: We studied 436 participants aged ≥55 years from the Electricity Generating Authority of Thailand study. They underwent a physical examination, an extensive cognitive assessment with the MoCA (cutoff <26 points), and a biochemical analysis related to diabetes and dyslipidemia. The blood mercury level was determined by inductively coupled plasma mass spectrometry. Genotyping of the MT1A rs8052394 SNP was performed by the restriction fragmentation length polymorphism method. Results: The mean age of the study population was 58.8±3.01 years, and most had ≥12 years of education (75.7%). The primary study finding was that the prevalence of mild cognitive impairment (MCI) in older Thai adults was 39.7%. The frequency distributions of the G allele of the rs8052394 SNP of the MT1A gene were significantly associated with the total and sub-domain MoCA scores. The prevalence of MCI was significantly associated with increased age, hypertriglyceridemia, hyperhomocysteinemia, the third tertile of blood mercury concentration, and the rs8052394 variant genotype of MT1A (P values for all odds ratios <0.05). Conclusion:These findings suggested that neurocognitive effects associate with mercury exposure and genetic susceptibility in toxicokinetics. Public health strategies can be used to implement as a comprehensive action plan to educate vulnerable populations on how to reduce mercury exposure. Concurrently, impact of such genetic predisposition requires replication for identifying and protecting susceptible individuals from mercury toxicity.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)

Sirivarasai¹,

Chaisungnern²,

Panpunuan³

et al. 2021

NDT

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“…Studies revealed heavy metals are neurotoxic and associated with impairment of the central nervous system (Chen et al, 2016). Moreover, some studies reported the association between metals exposure with detriments in attention and executive function (Bowler et al, 2007;Rafiee et al, 2020;Soetrisno & Delgado-Saborit, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Human biomonitoring (HBM) has been widely used as a reliable approach in human exposure assessment in the general population and occupational settings (Hoseini et al, 2018;Rafiee et al, 2018aRafiee et al, , 2018bRafiee et al, , 2019. Several biological matrices have been used in biomonitoring studies such as blood (Richmond-Bryant et al, 2014), urine (Hoseini et al, 2018;Rafiee et al, 2018a), serum (Alimonti et al, 2007;Skalny et al, 2017), plasma (Vural et al, 2010), nails (Carneiro et al, 2011;Coelho et al, 2013), and hair (Fábelová et al, 2018;Luo et al, 2014;Rafiee et al, 2020;Soetrisno & Delgado-Saborit, 2020;Varrica et al, 2014;Zhu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population

Rafiee

Delgado-Saborit

Aquilina

et al. 2021

Environ Geochem Health

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Concentrations of metals and metalloids derived mainly from anthropogenic activities have increased considerably in the environment. Metals might be associated with increase reactive oxygen species (ROS) damage, potentially related to several health outcomes. This study has recruited 200 adult participants, including 110 males and 90 females in Shiraz (Iran), to investigate the relationship between chronic exposure to metals and ROS damage by analyzing malondialdehyde (MDA) and 8-Oxo-2'-deoxyguanosine (8-OHdG) concentrations, and has evaluated the associations between chronic metal exposure and ROS damage using regression analysis. Our findings showed participants are chronically exposed to elevate As, Ni, Hg, and Pb levels. The mean urinary concentrations of 8-OHdG and MDA were 3.8 ± 2.35 and 214 ± 134 lg/g creatinine, respectively. This study shows that most heavy metals are correlated with urinary ROS biomarkers (R ranges 0.19 to 0.64). In addition, regression analysis accounting for other confounding factors such as sex, age, smoking status, and teeth filling with amalgam highlights that Al, Cu, Si and Sn are associated with

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“…Mining activities have had a considerable role in the pollution of the environment and are one of the most important point-source of soil and water contamination (García-Carmona et al 2017;Zhu et al 2019). In particular, metal mining can cause serious health risks as metals are usually toxic at low concentrations and not degradable, thus remaining in soil and water environments for long periods (Alloway 2013;Langård 2015;Padoan et al 2019;Rafiee et al 2020;Mokhtarzadeh et al 2020).…”

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confidence: 99%

Potential Release of Zinc and Cadmium From Mine-Affected Soils Under Flooding, a Mesocosm Study

Padoan

Kath

Vahl

et al. 2020

Arch Environ Contam Toxicol

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Metal-contaminated mining soils pose serious environmental and health risks if not properly managed, especially in mountainous areas, which are more susceptible to perturbation. Currently, climate change is leading to more frequent and intense rain events, which cause flooding episodes, thereby altering soil redox equilibria and contaminants stability. We evaluated the potential release of Zn and Cd (two of the most common inorganic contaminants) and the factors regulating their solubility and speciation in two heavily contaminated soils representative of a Zn-mining area. The soils were flooded under aerobic (for 24 h) and anaerobic (for 62 days) conditions using mesocosm experiments, sequential extractions, and geochemical modelling. Leaching trials under aerobic conditions showed a high release of Zn and Cd (10 times the legislative limits), with metals possibly migrating via water infiltration or runoff. Under anaerobic conditions Zn and Cd were initially released. Then, solution concentrations decreased gradually (Zn) or sharply (Cd) until the end of the experiment. Sequential extractions and multisurface modelling indicated that both metals precipitated mainly as carbonates. This was confirmed by a geochemical multisurface modelling, which also predicted the formation of sulphides after 60 days in one soil. The model calculated metals to be preferentially complexed by organic matter and well predicted the observed soil solution concentrations. The results showed that during flooding episodes contaminants could be promptly transferred to other environmental compartments. The use of multisurface modelling coupled with laboratory experiments provided useful indications on the potential release and speciation in case of anoxic conditions.

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Environmental chronic exposure to metals and effects on attention and executive function in the general population

Cited by 42 publications

References 121 publications

Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)

Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)

Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population

Potential Release of Zinc and Cadmium From Mine-Affected Soils Under Flooding, a Mesocosm Study

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