Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population

Abstract

Concentrations of metals and metalloids derived mainly from anthropogenic activities have increased considerably in the environment. Metals might be associated with increase reactive oxygen species (ROS) damage, potentially related to several health outcomes. This study has recruited 200 adult participants, including 110 males and 90 females in Shiraz (Iran), to investigate the relationship between chronic exposure to metals and ROS damage by analyzing malondialdehyde (MDA) and 8-Oxo-2'-deoxyguanosine (8-OHdG) concentrations, and has evaluated the associations between chronic metal exposure and ROS damage using regression analysis. Our findings showed participants are chronically exposed to elevate As, Ni, Hg, and Pb levels. The mean urinary concentrations of 8-OHdG and MDA were 3.8 ± 2.35 and 214 ± 134 lg/g creatinine, respectively. This study shows that most heavy metals are correlated with urinary ROS biomarkers (R ranges 0.19 to 0.64). In addition, regression analysis accounting for other confounding factors such as sex, age, smoking status, and teeth filling with amalgam highlights that Al, Cu, Si and Sn are associated with

The evaluation of liver dysfunction and oxidative stress due to urban environmental pollution in Mexican population related to Madin Dam, State of Mexico: a pilot study

“…Oxidative stress is caused by a disturbance in the balance between ROS production and antioxidant defenses (Sies 2015). There is evidence that various pathophysiological processes, habits and lifestyle can trigger an increase in ROS, but also environmental pollutants can cause oxidative deterioration in organisms (Aslan et al 1997;Carraro et al 2018;Rafiee et al 2021). The elevation of ROS production leads to an increase in the level of lipid peroxidation; during this process, polyunsaturated fatty acids with double bonds react with ROS, particularly the hydroxyl radical (HO −) and the reactive nitrogen species peroxynitrite (ONOO −), through a chain reaction mechanism.…”

Essential Trace Elements in Scalp Hair of Residents across the Caspian Oil and Gas Region of Kazakhstan

“…The researchers describe the change in the concentration of heavy metals belonging to both the toxic group and the essential and conditionally essential groups in the regions of industrial and petrochemical pollution. Moreover, it is stated that the concentration of metals and metalloids formed mainly as a result of anthropogenic activity in the environment has increased significantly [ 14 , 15 ].…”