Environmental behaviour and ecotoxicity of quantum dots at various trophic levels: A review

Rocha, Thiago Lopes; Mestre, Nélia C.; Sabóia‐Morais, Simone Maria Teixeira de; Bebianno, Maria João

doi:10.1016/j.envint.2016.09.021

Cited by 124 publications

(68 citation statements)

References 107 publications

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“…Although there is a great deal of concern about the potential hazards of QDs containing heavy metals, the toxicity of QDs is a topic of controversy. The toxicity and ecotoxicity of QDs is studied at various levels of biological organization, from cell monolayers to primates and even ecosystems [34–35]. The potential toxicological effects of QDs are usually based on the release of free cadmium (Cd) [36].…”

Section: Discussionmentioning

confidence: 99%

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Saulīte¹,

Dapkutė²,

Pleiko³

et al. 2017

Beilstein J. Nanotechnol.

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Nanotechnology-based drug design offers new possibilities for the use of nanoparticles in imaging and targeted therapy of tumours. Due to their tumour-homing ability, nano-engineered mesenchymal stem cells (MSCs) could be utilized as vectors to deliver diagnostic and therapeutic nanoparticles into a tumour. In the present study, uptake and functional effects of carboxyl-coated quantum dots QD655 were studied in human skin MSCs. The effect of QD on MSCs was examined using a cell viability assay, Ki67 expression analysis, and tri-lineage differentiation assay. The optimal conditions for QD uptake in MSCs were determined using flow cytometry. The QD uptake route in MSCs was examined via fluorescence imaging using endocytosis inhibitors for the micropinocytosis, phagocytosis, lipid-raft, clathrin- and caveolin-dependent endocytosis pathways. These data showed that QDs were efficiently accumulated in the cytoplasm of MSCs after incubation for 6 h. The main uptake route of QDs in skin MSCs was clathrin-mediated endocytosis. QDs were mainly localized in early endosomes after 6 h as well as in late endosomes and lysosomes after 24 h. QDs in concentrations ranging from 0.5 to 64 nM had no effect on cell viability and proliferation. The expression of MSC markers, CD73 and CD90, and hematopoietic markers, CD34 and CD45, as well as the ability to differentiate into adipocytes, chondrocytes, and osteocytes, were not altered in the presence of QDs. We observed a decrease in the QD signal from labelled MSCs over time that could partly reflect QD excretion. Altogether, these data suggest that QD-labelled MSCs could be used for targeted drug delivery studies.

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Section: Discussionmentioning

confidence: 99%

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Saulīte¹,

Dapkutė²,

Pleiko³

et al. 2017

Beilstein J. Nanotechnol.

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“…Engineered nanomaterials (ENMs) have unique physical–chemical properties that differ from conventional bulk materials, allowing for a range of evolving applications (Vollath ) and potential environmental concerns (Valsami‐Jones and Lynch ). There are many types of ENMs including the carbon‐based fullerenes, graphenes (Ren and Cheng ; Zurutuza and Marinelli ; Chee et al ) and nanotubes (De Volder et al ), metallic ENMs such as metal oxides (e.g., TiO 2 ; Al‐Kattan et al ) and zero‐valent metals (e.g., Ag 0 ; Zhang ), nanopolymers (Chee et al ), and quantum dots (Rocha et al ; Xiao et al ). These different types, as well as the varieties within each type, give rise to seemingly endless applications for ENMs in medicine, technology, and consumer products.…”

Section: Introductionmentioning

confidence: 99%

Assessing the release of copper from nanocopper‐treated and conventional copper‐treated lumber into marine waters I: Concentrations and rates

Parks

Cantwell

Katz

et al. 2018

Enviro Toxic and Chemistry

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Little is known about the release of metal engineered nanomaterials (ENMs) from consumer goods, including lumber treated with micronized copper. Micronized copper is a recent form of antifouling wood preservative containing nanosized copper particles for use in pressure-treated lumber. The present study investigated the concentrations released and the release rate of total copper over the course of 133 d under freshwater, estuarine, and marine salinity conditions (0, 1, 10, and 30‰) for several commercially available pressure-treated lumbers: micronized copper azole (MCA) at 0.96 and 2.4 kg/m , alkaline copper quaternary (ACQ) at 0.30 and 9.6 kg/m , and chromated copper arsenate (CCA) at 40 kg/m . Lumber was tested as blocks and as sawdust. Overall, copper was released from all treated lumber samples. Under leaching conditions, total release ranged from 2 to 55% of the measured copper originally in the lumber, with release rate constants from the blocks of 0.03 to 2.71 (units per day). Generally, measured release and modeled equilibrium concentrations were significantly higher in the estuarine conditions compared with freshwater or marine salinities, whereas rate constants showed very limited differences between salinities. Furthermore, organic carbon was released during the leaching and demonstrated a significant relationship with released copper concentrations as a function of salinity. The results indicate that copper is released into estuarine/marine waters from multiple wood treatments including lumber amended with nanoparticle-sized copper. Environ Toxicol Chem 2018;37:1956-1968. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

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“…On the other hand, several studies showed that QDs caused different degrees of toxicity in vivo and in vitro. Though, it depends on the physical and chemical properties of the QDs, capping, dose, model organisms and exposure time (e.g., for a review see [14,21,22]).…”

Section: Discussionmentioning

confidence: 99%

“…Quantum dots (QDs) are a distinct type of nanoparticles with several potential applications in the electronics industry and in biomedical applications [19,20]. QDs are semiconductor metalloid nanocrystals (~2-100 nm) showing unique optical and electrical properties [2,21,22]. Furthermore, zinc sulfide (ZnS), zinc-selenium (ZnSe), cadmium sulfide (CdS), cadmium-selenium (CdSe), and cadmium-tellurium (CdTe) cores belong to the group II-IV series QDs and are defined as particles with physical dimensions smaller than the exciton Bohr radius [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation of Quantum Dots (ZnS and CdS) Singly and Combined in Zebrafish (Danio rerio)

Matos

Martins

Cid‐Samamed

et al. 2019

IJERPH

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The exponential growth of nanotechnology has led to the production of large quantities of nanomaterials for numerous industrial, technological, agricultural, environmental, food and many other applications. However, this huge production has raised growing concerns about the adverse effects that the release of these nanomaterials may have on the environment and on living organisms. Regarding the effects of QDs on aquatic organisms, existing data is scarce and often contradictory. Thus, more information is needed to understand the mechanisms associated with the potential toxicity of these nanomaterials in the aquatic environment. The toxicity of QDs (ZnS and CdS) was evaluated in the freshwater fish Danio rerio. The fishes were exposed for seven days to different concentrations of QDs (10, 100 and 1000 µg/L) individually and combined. Oxidative stress enzymes (catalase, superoxide dismutase and glutathione S-transferase), lipid peroxidation, HSP70 and total ubiquitin were assessed. In general, results suggest low to moderate toxicity as shown by the increase in catalase activity and lipid peroxidation levels. The QDs (ZnS and CdS) appear to cause more adverse effects singly than when tested combined. However, LPO results suggest that exposure to CdS singly caused more oxidative stress in zebrafish than ZnS or when the two QDs were tested combined. Levels of Zn and Cd measured in fish tissues indicate that both elements were bioaccumulated by fish and the concentrations increased in tissues according to the concentrations tested. The increase in HSP70 measured in fish exposed to 100 µg ZnS-QDs/L may be associated with high levels of Zn determined in fish tissues. No significant changes were detected for total ubiquitin. More experiments should be performed to fully understand the effects of QDs exposure to aquatic biota.

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Environmental behaviour and ecotoxicity of quantum dots at various trophic levels: A review

Cited by 124 publications

References 107 publications

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Assessing the release of copper from nanocopper‐treated and conventional copper‐treated lumber into marine waters I: Concentrations and rates

Toxicity Evaluation of Quantum Dots (ZnS and CdS) Singly and Combined in Zebrafish (Danio rerio)

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