Environmental Behaviors and Toxicities of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons

Hayakawa, Kazuichi

doi:10.1248/cpb.c15-00801

Cited by 96 publications

(48 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PAHs are a class of organic compounds produced by incomplete combustion or high-pressure processes (23,24) that can affect human health. The present study investigated the hypothesis of an association between BPDE-DNA adducts in human sperms and fertility.…”

Section: Discussionmentioning

confidence: 99%

B(a)P adduct levels and fertility: A cross-sectional study in a Sicilian population

Conti

Calogero

Giacone

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Benzo(a)pyrene (BaP) is a carcinogenic polycyclic aromatic hydrocarbon for human tissues. Still today it is not fully investigated if BaP can affect negatively the male fertility through the BaP-DNA adducts production. In the present study, BaP Tetrol I-1 (TI-1) and BaP Tetrol II-2 (TII-2) BaP-DNA adducts were investigated in spermatozoa of a Sicilian male population. Semen samples from 86 volunteers in two eastern Sicilian cities (Regalbuto and Melilli) were collected. The quality of semen was evaluated in all samples according to the World Health Organization (WHO) guidelines. We analyzed BaP-DNA adducts in extracted sperm cell DNA using the modified high-performance liquid chromatography-fluorescence method to detects both Tetrols. Differences between Tetrol levels were assessed by the Wilcoxon signed-rank test and the Mann-Whitney U test, as appropriate. Correlation between semen quality parameters and Tetrol concentrations were analyzed using the Spearman's correlation coefficient. Σ(TI-1+TII-2) were significantly higher in spermatozoa of volunteers from Regalbuto. Furthermore, a greater dispersion of the levels of adducts was observed in these specimens. TI-1 adducts were higher than TII-2 in Melilli samples (95% CI) and TII-2 were higher than TI-1 in Regalbuto semen samples (95% CI). A significant inverse correlation between sperm progressive motility and both TI-1 and TII-2 adducts was observed. The present study showed that BaP negatively affects male fertility by TI-1 and TII-2 DNA-adduct production. These results suggest that DNA adducts could be used as biomarker to assess BaP exposure by air pollution. Further studies are needed to confirm if these findings could affect male fertility because of the growing impairment of this function observed in recent years.

show abstract

Section: Discussionmentioning

confidence: 99%

B(a)P adduct levels and fertility: A cross-sectional study in a Sicilian population

Conti

Calogero

Giacone

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Several higher‐level NPAHs (2‐nitrofluorene, 9‐nitroanthracene, 9‐nitrophenanthrene, 3‐nitrofluoranthene, 1‐nitropyrene, 2,7‐dinitrofluorene, 7‐nitrobenz[ a ]anthracene and 6‐nitrochrysene) in the atmosphere could be collected by using a low‐volume air sampler (38 L/min, 24 h) (Tutino, Di Gilio, Laricchiuta, Assennato, & de Gennaro, ). On the other hand, because the concentrations of PAHs are usually higher than those of their corresponding NPAHs (Hayakawa, ; Nassar et al, ; Tang et al, ), either low‐ or high‐volume air samplers can be used. At high‐level pollution sites such as an industrial workplace (Chaspoul, Barban, & Gallice, ) or kitchen (Chen et al, ), personal samplers (1–3 L/min) have been used to collect particulate‐bound PAHs, NPAHs and oxygenated derivatives.…”

Section: Analytical Methods Of Polycyclic Aromatic Hydrocarbons and Nmentioning

confidence: 99%

“…Among them, GC–MS with negative ion chemical ionization (GC/NICI‐MS) (Alves et al, ; Kawanaka et al, ; Ringuet, Albinet, Leoz‐Garziandia, Budzinski, & Villenave, ), GC–MS (Tutino et al, ) and HPLC‐chemiluminescence detection (HPLC‐CLD) (Hayakawa, Kitamura, Butoh, Imaizumi, & Miyazaki, ; Hayakawa, Noji, Tang, Toriba, & Kizu, ; Hayakawa et al, ; Tang et al, , ; Tang, Toriba, Kizu, & Hayakawa, ) (Figure ) were mostly used. By using the HPLC‐CLD method, we identified the environmental behaviors such as levels, compositions and main sources of NPAHs in cities located in the East Asian area (Tang, et al, ; Hayakawa et al, ).…”

Section: Analytical Methods Of Polycyclic Aromatic Hydrocarbons and Nmentioning

confidence: 99%

Recent analytical methods for atmospheric polycyclic aromatic hydrocarbons and their derivatives

Hayakawa

Tang

Toriba

2016

Biomedical Chromatography

Self Cite

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are ubiquitous environmental pollutants. Moreover, some oxidative metabolites of these pollutants, such as hydroxylated and epoxide PAHs, cause endocrine disruption or produce reactive oxygen species. These compounds have become a large concern from the viewpoint of particulate matter (PM ) pollution. This report deals with recent studies concerning analytical methods for PAHs, NPAHs and related compounds in atmospheric and biological samples.

show abstract

“…In a study that measured concentrations of nine PAHs in the total PM in Tokyo, and in Kanagawa Prefecture (in the Kanto region), from 1997 to 2014, the total concentration of all nine PAHs ('PAH) in winter decreased by a factor of about 3.6 from 1997 to 2005 and then remained steady from 2008 to 2014. 46) The initial large decrease in 'PAH was interpreted to result of a corresponding decrease in PAH emissions from vehicles. 46) The similarity in the temporal changes in 'PAH and M BC in Tokyo is consistent with the similarities of their sources, as discussed in section 1.…”

Section: Emission Of Bc In Tokyo and Japanmentioning

confidence: 99%

Changes in black carbon and PM<sub>2.5</sub> in Tokyo in 2003–2017

Mori

Ohata

Morino

et al. 2020

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

View full text Add to dashboard Cite

Black carbon (BC) particles cause adverse health effects and contribute to the heating of the atmosphere by absorbing visible solar radiation. Efforts have been made to reduce BC emissions, especially in urban areas; however, long-term measurements of BC mass concentration (M BC) are very limited in Japan. We report M BC measurements conducted in Tokyo from 2003 to 2017, showing that M BC decreased by a factor of 3 from 2003 to 2010 and was stable from 2010 to 2017. Fine particulate concentrations (PM 2.5) decreased by a much smaller factor during 2003-2010. The diurnal variations of BC size distributions suggest that the BC in Tokyo originates mainly from local sources, even after 2010. Our three-dimensional model calculations show that BC from the Asian continent contributes a small portion (about 20%) of the annual average M BC in the Kanto region of Japan, which includes Tokyo. This indicates that continued reduction of BC emissions inside Japan should be effective in further decreasing M BC .

show abstract

Environmental Behaviors and Toxicities of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons

Cited by 96 publications

References 52 publications

B(a)P adduct levels and fertility: A cross-sectional study in a Sicilian population

B(a)P adduct levels and fertility: A cross-sectional study in a Sicilian population

Recent analytical methods for atmospheric polycyclic aromatic hydrocarbons and their derivatives

Changes in black carbon and PM<sub>2.5</sub> in Tokyo in 2003–2017

Contact Info

Product

Resources

About