Environmental and chemical carcinogenesis

Wogan, Gerald N.; Hecht, Stephen S.; Felton, James S.; Conney, Allan H.; Loeb, Lawrence A.

doi:10.1016/j.semcancer.2004.06.010

Cited by 563 publications

(387 citation statements)

References 37 publications

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“…In Gambia, this mutation was detected in DNA in cases of HCC and was not frequent in the control cases [76][77][78][79]. Transversions G→T or transitions G→A are produced in the third base of codon 249 of the p53 gene and in the first or second base of codon 12 of the H-ras gene [80][81][82][83][84][85]. [86].…”

Section: Oncogenes and Tumour Suppressor Gene P53mentioning

confidence: 99%

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

Carvajal-Moreno¹

2017

J Pharmacovigil

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Aflatoxins are important etiological factors for cancers in the digestive system that have not been extensively studied. The present review describes reports of the presence of aflatoxins in cancers of the esophagus, stomach, pancreas, liver, colon and rectum. The presence of AFB 1 -FAPY adducts and mutations in codon 249 of the tumor suppressor gene p53 in colorectal cancer tumors and Ki-ras activation by point mutation in pancreas cancer are reliable criteria to accept AFs as an important etiological factor. The Ministries of Health of the different countries should perform more preventive practices on crops in the field and in warehouses; they should chemically analyze aflatoxins in fresh and industrialized foods for humans and feeds for animals to avoid the presence of these dangerous toxins.

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Section: Oncogenes and Tumour Suppressor Gene P53mentioning

confidence: 99%

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

Carvajal-Moreno¹

2017

J Pharmacovigil

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“…15 However, the exogenous exposure to xenobiotics is deemed more important in toxicology and cancer risk assessment. 16 Examples of exogenous DNA adduct formation consists of DNA damage by dietary toxins such as mycotoxins, acrylamide and heterocyclic amines (HAAs). [17][18][19] Of course, several other environmental lifestyle factors can also significantly contribute to genotoxin exposure and exogenous DNA adduct formation; e.g.…”

Section: Dna Adduct Analysis As a Means To Study Genotoxin Exposure mentioning

confidence: 99%

Mass Spectrometric Mapping of the DNA Adductome as a Means to Study Genotoxin Exposure, Metabolism, and Effect

2016

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Covalent binding of endo-or exogenous chemicals to DNA results in the formation of DNA adducts which are reflective of exposure of the human body to DNA-damaging molecules and their metabolic pathways. The study of DNA adduct types and levels in human tissue therefore offers an interesting tool in several fields of research, including toxicology and cancer epidemiology. Over the years, a range of techniques and methods have been developed to study the formation of endo-and exogenous DNA adducts. However, for the simultaneous detection, identification and quantification of both known and unknown DNA adducts, mass spectrometry (MS) is deemed to be the most promising technique. In this perspective, we focus on the analysis of multiple DNA adducts within a sample with the emphasis on untargeted analysis. The advantageous use of MS methodologies for DNA adductome mapping is discussed comprehensively with relevant field examples. In addition, several aspects of study design, sample pretreatment and analysis are addressed as these factors significantly affect the reliability of DNA adductomics studies.

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“…Their harmful presence in the ecosphere has been largely demonstrated by their toxicity to humans and many forms of terrestrial and aquatic life 1 . They show pro-carcinogenic or carcinogenic, endocrine disruption, neurotoxic, teratogenic activities in addition to several other deleterious effects upon exposure to animals, including humans [1][2][3][4][5][6][7] . Biological conversion of POPs into products with increased toxicity, which is known from the bioactivation of xenobiotics in mammals, represents an additional serious health and environmental problem 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…The U.S. Environmental Protection Agency (US EPA) has suggested a group of 16 PAHs as priority pollutants, but even though PAHs are not listed under the Stockholm Convention, actually there is enough scientific information about their adverse effects to the organisms to put this group on review process 1,2,4,5,13 . This group of POPs have their genesis from both natural and anthropogenic sources; however, those PAHs originated from petrogenic and pyrogenic sources are actually of special concern due to their uncontrolled emissions and ubiquitous presence in the environment 1,[14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

“…Due to their large log K ow these compounds are readily absorbed and accumulated by marine organisms from polluted waters 7,19,20 . The accumulation of PAH and organochlorine compounds in bivalves is a consequence of an inefficient or complete absence of mixed-function oxidase (MFO) enzymes that use the cytochrome P-450 electron transfer system (CYP1A), a protein that plays a critical role in the oxidation of numerous xenobiotics 2,5 . The metabolism of PAHs by CYP1A yields to oxidized products with different levels of toxicity, resulting in deleterious effects on the organisms 21 .…”

Section: Introductionmentioning

confidence: 99%

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Polycyclic Aromatic Hydrocarbons and Polychlorinated Biphenyls in Coastal Environments of Valdivia and Valparaíso, Chile

Palma-Fleming

Cornejo

González

et al. 2008

J. Chil. Chem. Soc.

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PAHs and PCBs were measured in the mussel Perumytilus purpuratus (Lamarck) collected from three different sites along the coast of Valdivia and Valparaiso, South-Central and Central Chile, respectively. Pollution at these sites is considered low with PAHs originating mainly from pyrolytic sources according to the Phenanthrene/Anthracene and Fluoranthene/Pyrene ratios. Temporal variation of PAHs was observed in Valdivia, while site variation was observed along the

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Environmental and chemical carcinogenesis

Cited by 563 publications

References 37 publications

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

Mass Spectrometric Mapping of the DNA Adductome as a Means to Study Genotoxin Exposure, Metabolism, and Effect

Polycyclic Aromatic Hydrocarbons and Polychlorinated Biphenyls in Coastal Environments of Valdivia and Valparaíso, Chile

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