Environmental and behavioural head and neck cancer risk factors

Boras, Vanja Vučičević; Fučić, Aleksandra; Baranović, Sandra; Blivajs, Igor; Milenović, Maja; Bišof, Vesna; Rakušić, Zoran; Ceppi, Marcello; Bruzzone, Marco

doi:10.21101/cejph.a5565

Cited by 20 publications

(12 citation statements)

References 27 publications

(26 reference statements)

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“…but also other types of cancer. 23 , 24 That might explain the fact that the proportions of men and former or current smokers, as well as the mean age, were higher in the advanced-stage cancer group than in the control group. In a search of the literature, we found no clear evidence of an association between chest X-ray severity at the time of MAC lung disease diagnosis and advanced-stage cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of coexisting advanced extrapulmonary solid cancer on progression of Mycobacterium avium complex lung disease

et al. 2021

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Objective: Although Mycobacterium avium complex (MAC) lung disease has been shown to be associated with lung cancer and hematologic malignancies, there have been few studies of its relationships with other types of cancer. The aim of this study was to assess the effect that coexisting advanced extrapulmonary solid tumors have on the progression of MAC lung disease. Methods: This was a retrospective study of patients diagnosed with MAC lung disease, on the basis of the American Thoracic Society (ATS) criteria, between October of 2005 and March of 2019. The patients were divided into three groups: those with advanced-stage cancer (A-SC group); those with early-stage cancer (E-SC group); and those without cancer (control group). Progression of MAC lung disease was defined as exacerbation seen on imaging. Patient characteristics and the time to progression were compared among the three groups. Results: A total of 286 patients met the ATS diagnostic criteria for MAC lung disease, and 128 of those were excluded. Of the remaining 158 patients, 20 (7.0%) were in the A-SC group, 36 (12.6%) were in the E-SC group, and 102 (35.7%) were in the control group. The median time to progression in the A-SC, E-SC, and control groups was 432, 3,595, and 2,829 days, respectively (p < 0.01). A proportional hazards model showed that the significant predictors of MAC lung disease progression were advanced-stage cancer (hazard ratio [HR] = 6.096; 95% CI: 2.688-13.826; p < 0.01), cavitary lesions (HR = 2.750; 95% CI: 1.306-5.791; p < 0.01), and a high Nodule-Infiltration-Cavity-Ectasis score (HR = 1.046; 95% CI: 1.004-1.091; p = 0.033). Conclusions: A coexisting advanced extrapulmonary solid tumor could hasten the progression of MAC lung disease.

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Section: Discussionmentioning

confidence: 99%

Effect of coexisting advanced extrapulmonary solid cancer on progression of Mycobacterium avium complex lung disease

et al. 2021

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“…[ 37 ]. Finally, our population was not profiled on tobacco use, which is a well-known behavioral risk factor for head and neck cancer [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Quality of life and health-related utility after trans-oral surgery for head and neck cancers

Parimbelli

Simon²,

Soldati³

et al. 2021

Health Qual Life Outcomes

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Purpose The purpose of this study was to assess utility coefficients of health states following two minimally invasive surgical approaches for head and neck cancer, namely trans-oral robotic surgery and trans-oral laser microsurgery. Those utility coefficients will be later exploited in an economic evaluation study comparing the two approaches. Methods The above cited economic evaluation will be done from the Swiss healthcare system perspective and, as such, Swiss healthcare professionals were interviewed to elicit utility coefficients. Health states, ranging from remission to palliative care, were described using clinical vignettes. A computerized tool (UceWeb) implementing standard gamble and rating scale methods was used. Results Utility coefficients for 18 different health states were elicited with the two methods from 47 individuals, for a total of 1692 values. Elicited values varied from 0.980 to 0.213. Comparison with values elicited in previous studies show the need for population-specific elicitation, mainly for the worst health states. Conclusion Herein we report health utility coefficients for the Swiss population for health states following minimally invasive trans-oral surgery. This study provides utility values that can be used not only for a specific cost-utility analysis, but also for future studies involving the same health states.

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“…They discussed smoking and low education as significant risk factors for HNC regardless of gender. Family HNC and breast cancer were significant risk predictors ( Vučičević Boras et al, 2019 ). Omics-based approaches might offer novel tools for diagnosis and treatment of head and neck malignancies in the field of precision health ( Adeola et al, 2019 ).…”

Section: Environmental and Life-style Determinants Of Hnsccmentioning

confidence: 99%

Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer

Affolter

Lammert

Kern

et al. 2021

Front. Cell Dev. Biol.

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Despite the current progress in the development of new concepts of precision medicine for head and neck squamous cell carcinoma (HNSCC), in particular targeted therapies and immune checkpoint inhibition (CPI), overall survival rates have not improved during the last decades. This is, on the one hand, caused by the fact that a significant number of patients presents with late stage disease at the time of diagnosis, on the other hand HNSCC frequently develop therapeutic resistance. Distinct intratumoral and intertumoral heterogeneity is one of the strongest features in HNSCC and has hindered both the identification of specific biomarkers and the establishment of targeted therapies for this disease so far. To date, there is a paucity of reliable preclinical models, particularly those that can predict responses to immune CPI, as these models require an intact tumor microenvironment (TME). The “ideal” preclinical cancer model is supposed to take both the TME as well as tumor heterogeneity into account. Although HNSCC patients are frequently studied in clinical trials, there is a lack of reliable prognostic biomarkers allowing a better stratification of individuals who might benefit from new concepts of targeted or immunotherapeutic strategies. Emerging evidence indicates that cancer stem cells (CSCs) are highly tumorigenic. Through the process of stemness, epithelial cells acquire an invasive phenotype contributing to metastasis and recurrence. Specific markers for CSC such as CD133 and CD44 expression and ALDH activity help to identify CSC in HNSCC. For the majority of patients, allocation of treatment regimens is simply based on histological diagnosis and on tumor location and disease staging (clinical risk assessments) rather than on specific or individual tumor biology. Hence there is an urgent need for tools to stratify HNSCC patients and pave the way for personalized therapeutic options. This work reviews the current literature on novel approaches in implementing three-dimensional (3D) HNSCC in vitro and in vivo tumor models in the clinical daily routine. Stem-cell based assays will be particularly discussed. Those models are highly anticipated to serve as a preclinical prediction platform for the evaluation of stable biomarkers and for therapeutic efficacy testing.

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Environmental and behavioural head and neck cancer risk factors

Cited by 20 publications

References 27 publications

Effect of coexisting advanced extrapulmonary solid cancer on progression of Mycobacterium avium complex lung disease

Effect of coexisting advanced extrapulmonary solid cancer on progression of Mycobacterium avium complex lung disease

Quality of life and health-related utility after trans-oral surgery for head and neck cancers

Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer

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