Entry of human cytomegalovirus into porcine endothelial cells depends on both the cellular vascular origin and the viral strain

Taveira, Aline; Ponroy, Nicolas; Mueller, Nicolas J.; Millard, Anne-Laure

doi:10.1111/xen.12097

Cited by 6 publications

(5 citation statements)

References 54 publications

(76 reference statements)

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“…In infected cells, abnormal apoptotic changes may play an important role in the pathogenesis. HCMV infection induces apoptosis in cultured ECs [ 84 ]. The apoptosis rate increases throughout the course of infection.…”

Section: Possible Mechanism Of Hcmv Infection Developing To Atherosclmentioning

confidence: 99%

Human cytomegalovirus infection and coronary heart disease: a systematic review

Zhang

Liu

2018

Virol J

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BackgroundHuman cytomegalovirus (HCMV) infection is closely associated with coronary heart disease.Main body of the abstractIn 1987, Adam et al. were the first to report an association between HCMV infection and atherosclerosis (AS), and later, many serum epidemiology and molecular biology studies showed that HCMV-infected endothelial cells play an important role in the development of AS. As patients with HCMV are generally susceptible to coronary heart disease, and with the increasing elderly population, a review of recent studies focusing on the relationships of HCMV infection and coronary heart disease is timely and necessary.Short conclusionThe role of HCMV infection in the development of AS needs further study, since many remaining issues need to be explored and resolved. For example, whether HCMV promotes the development of coronary AS, and what the independent factors that lead to coronary artery AS by viral infection are. A comprehensive understanding of HCMV infection is needed in order to develop better strategies for preventing AS.

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Section: Possible Mechanism Of Hcmv Infection Developing To Atherosclmentioning

confidence: 99%

Human cytomegalovirus infection and coronary heart disease: a systematic review

Zhang

Liu

2018

Virol J

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“…Porcine cells can be infected by HCMV [17], indicating that the pig transplants may be infected when the recipient is HCMV positive, and PCMV can infect human cells [18]. Entry of HCMV into porcine endothelial cells depends on both the cellular vascular origin and the viral strain [19]. When PCMV was transmitted by the pig transplant into baboons, the baboon CMV was activated causing invasive disease and consumptive coagulopathy, the PCMV was mainly replicating in the pig transplant causing ureteric necrosis in one transplant [20e22].…”

Section: Pcmv and Other Herpesvirusesmentioning

confidence: 99%

Preventing transfer of infectious agents

Denner

Mueller

2015

International Journal of Surgery

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Xenotransplantation using pig cells, tissues and organs may be associated with the transfer of porcine infectious agents, which may infect the human recipient and in the worst case induce a disease (zoonosis). To prevent this, a broad screening program of the donor animals for putative zoonotic microorganisms, including bacteria, viruses, fungi and others, using sensitive and specific detection methods has to be performed. As long as it is still unknown, which microorganism represents a real risk for the recipient, experience from allotransplantation should be brought in. Due to the fact that pigs can be screened long before the date of transplantation, xenotransplantation will become eventually safer compared with allotransplantation. Screening and selection of animals free of potential zoonotic microorganisms, Caesarean section, vaccination and/or treatment with chemotherapeutics are the strategies of choice to obtain donor animals not transmitting microorganisms. In the case of porcine endogenous retroviruses (PERVs) which are integrated in the genome of all pigs and which cannot be eliminated this way, selection of animals with low virus expression and generation of genetically modified pigs suppressing PERV expressions may be performed.

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“…Ubiquitous herpesviruses, such as human cytomegalovirus (CMV) and human herpesvirus 1 (HHV‐1), also known as herpes simplex virus, while normally latent, can reactivate following therapeutic immunosuppression during transplantation. CMV has been shown to infect and modulate pig cells . If the cells contain PERV, then a herpesvirus infection can also result in the expression of PERV proteins .…”

Section: Zoonosismentioning

confidence: 99%