Human cytomegalovirus infection and coronary heart disease: a systematic review

Du, Yu; Zhang, Guangxue; Liu, Zhijun

doi:10.1186/s12985-018-0937-3

Cited by 47 publications

(44 citation statements)

References 124 publications

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“…These interactions allow cross-communication between different cell types, at different hierarchical levels, translating environmental signals into molecular signals (2,7). The pro-inflammatory profile becomes strategic throughout the lifespan (8)(9)(10)(11) -an increase of cytokine secretion, also thought to be associated with the influence of CMV-infection, may be at least partly responsible for age-associated degenerative disorders (12)(13)(14)(15)(16). Previous studies usually investigated individual roles of different cytokines, inflammatory mediators or metabolic factors in the age-related physiological alterations (17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Network Topology Dynamics of Circulating Biomarkers and Cognitive Performance in Older Cytomegalovirus-seropositive or -seronegative Men and Women

Benedetto

Müller

Rauskolb

et al. 2019

Preprint

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Background: Cytokines are signaling molecules operating within complex cascade patterns and having exceptional modulatory functions. They impact various physiological processes such as neuroendocrine and metabolic interactions, neurotrophins' metabolism, neuroplasticity, and may affect behavior and cognition. In our previous study, we found that sex and Cytomegalovirus (CMV)-serostatus may modulate levels of circulating pro-and antiinflammatory cytokines, metabolic factors, immune cells, and cognitive performance, as well as associations between them. Results: In the present study, we used a graph-theoretical approach to investigate the network topology dynamics of 22 circulating biomarkers and 11 measures of cognitive performance in 161 older participants recruited to undergo a six-months training intervention. For network construction, we applied coefficient of determination (R 2 ) that was calculated for all possible pairs of variables (N = 33) in four groups (CMVmen and women; CMV + men and women). Network topology has been evaluated by clustering coefficient (CC) and characteristic path length (CPL) as well as local (Elocal) and global (Eglobal) efficiency, showing the degree of network segregation (CC and Elocal) and integration (CPL and Eglobal). We found that networks under consideration showed small-world networks properties with more random characteristics. Mean CC, as well as local and global efficiency were highest and CPL shortest in CMVmales (having lowest inflammatory status and highest cognitive performance). CMVand CMV + females did not show any significant differences. Modularity analyses showed that the networks exhibit in all cases highly differentiated modular organization (with Q-value ranged between 0.397 and 0.453). Conclusions: In this work, we found that segregation and integration properties of the network were notably stronger in the group with balanced inflammatory status. We were also able to confirm our previous findings that CMV-infection and sex modulate multiple circulating biomarkers and cognitive performance and that balanced inflammatory and metabolic status in elderly contributes to better cognitive functioning. Thus, network analyses provide a useful strategy for visualization and quantitative description of multiple interactions between various circulating pro-and anti-inflammatory biomarkers, hormones, neurotrophic and metabolic factors, immune cells, and measures of cognitive performance and can be in general applied for analyzing interactions between different physiological systems.

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Section: Introductionmentioning

confidence: 99%

Network Topology Dynamics of Circulating Biomarkers and Cognitive Performance in Older Cytomegalovirus-seropositive or -seronegative Men and Women

Benedetto

Müller

Rauskolb

et al. 2019

Preprint

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“…Although the relevant infectious agents of VaD have not been studied more than those of AD, the stronger association of CMV diseases with VaD than AD is an interesting finding of this study. This result suggests that CMV may play a role in complex VaD pathogenesis, as active recurrent intermittent CMV replication is associated with chronic inflammatory atherosclerosis, vascular damage, and ultimately, cerebrovascular/cardiovascular diseases (CVD) [7,27,28].…”

Section: Discussionmentioning

confidence: 99%

Association Between Cytomegalovirus End-organ Diseases and Moderate-to-Severe Dementia: A Population-Based Cohort Study

Lee

Kwon

Han

et al. 2020

Preprint

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Background: The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive end-organ diseases and moderate-to-severe dementia. Methods: The ICD 10th revision codes from the National Health Insurance Database covering the entire population of the Republic of Korea were used to classify patients into exposed (n = 687, age ≥40 years, with CMV disease) and unexposed (n = 3,435, without CMV disease) groups, matched by age and sex at a 1:5 ratio of exposed: unexposed. All non-HIV-1-infected subjects selected during 2010–2014 with a washout period of the previous 4 years were followed up until December 2016 to identify newly diagnosed cases of moderate-to-severe dementia. Results: Multivariate regression model (M3) adjusted for age, sex, low income, body mass index, transplantation status, malignant neoplasms, end-stage renal disease on dialysis, type 2 diabetes mellitus, hypertension, and dyslipidaemia showed a significantly higher incidence of dementia (odds ratio: 1.9; 95% confidence interval: 1.2–2.8) in the exposed group than that in the unexposed group. The risk of vascular dementia (2.9, 1.1–7.5) was higher than that of Alzheimer’s disease (1.6, 1.0–2.6) in the exposed group in M3. In M3, patients aged 40–59 years with CMV diseases had a significantly higher risk of all kinds of dementia than those aged 60-79 and ≥80 years (11.7, 2.5–49.4 vs. 1.8, 1.1–3.2 vs. 1.3, 0.5–2.8; P =0.025). Conclusions: CMV diseases may be associated with the risk of moderate-to-severe dementia.

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“…Even though the relevant infectious agents of VD have not been studied more than those of AD, the stronger association of CMV disease with VD than AD in this study will be interesting finding. This result suggests that CMV may play a possible role in complex VD pathogenesis because active recurrent intermittent CMV replication and/or latent CMV infection status is associated with chronic inflammatory atherosclerosis, vascular damage, and ultimately, cerebrovascular/cardiovascular diseases (CVDs) [27,28].…”

Section: Discussionmentioning

confidence: 99%

Association Between Cytomegalovirus Disease and Dementia: A Population-Based Cohort Study

Lee¹,

Kwon²,

Han³

et al. 2019

Preprint

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Background The association between human cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus assessed by serum immunoglobulin G plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive diseases and vascular dementia (VD) and Alzheimer’s disease (AD).MethodsThe International Classification of Diseases (ICD) 10th revision codes from the National Health Insurance Database covering entire people in Republic of Korea were used to classify patients: case group (n = 687), age ≥40 years with CMV tissue-invasive end-organ disease and control group (n = 3,435), without CMV disease, matched by age and sex (ratio, 1:5). The case and control subjects selected during 2010–2014 with a washout period of the previous 4 years were followed-up until December 2016.ResultsThe multivariate regression model adjusted for age and sex showed a significantly higher incidence of dementia (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.5–3.1) in the case group. The risk of VD (OR, 3.3; 95% CI, 1.3–8.4) was higher than that of AD (OR, 1.7; 95% CI, 1.1–2.8) in the case group. In age subgroup analysis adjusted for sex, patients aged 40–59 years with CMV disease had a significantly higher risk of all kinds of dementia than those aged 60-79 and ≥80 years (OR, 12.6; 95% CI, 3.3–48.8 vs. OR, 2.1; 95% CI, 1.3–3.4 vs. OR, 1.4; 95% CI, 0.7–2.9; P=0.021).Conclusions CMV disease may be associated with the risk of VD.

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Human cytomegalovirus infection and coronary heart disease: a systematic review

Cited by 47 publications

References 124 publications

Network Topology Dynamics of Circulating Biomarkers and Cognitive Performance in Older Cytomegalovirus-seropositive or -seronegative Men and Women

Network Topology Dynamics of Circulating Biomarkers and Cognitive Performance in Older Cytomegalovirus-seropositive or -seronegative Men and Women

Association Between Cytomegalovirus End-organ Diseases and Moderate-to-Severe Dementia: A Population-Based Cohort Study

Association Between Cytomegalovirus Disease and Dementia: A Population-Based Cohort Study

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