The intention of this article is to explore the entropy generation of the Carreau hybrid nanofluid in a permeable rotating disk in the presence of thermal radiation, heat generation, and viscous dissipation. By applying the self-similarity variables, the partial differential equations are converted into ordinary differential equations and then the homotopy perturbation method is performed. Graphene oxide (Go) and Silver (Ag) are nanoparticles and kerosene oil as a base fluid is considered. Compared to the numerical technique (Runge-Kutta method), the homotopy perturbation method generates more precise and dependable results. The influence of sundry parameters is exhibited graphically for velocity, temperature, entropy generation, Bejan number, skin friction coefficient, and Nusselt number. The higher values of the Weissenberg number enhance the velocity profile and the opposite nature is observed in the porosity parameter. The entropy generation increases for larger values of the thermal radiation and electric field parameters. Carreau nanofluid expands under higher stress on the surface of the wall than Newtonian fluid. This type of problem would be used for electric devices and solar thermal systems. Moreover, the selected nanoparticles Graphene oxide and Silver play an important role in the biofunctionalization of protein, antibacterial, and anticancer therapy.