Entropy Contribution toward Micelle-Driven Deintercalation of Drug–DNA Complex

Patra, Animesh; Hazra, Soumitra; Kumar, Gopinatha Suresh; Mitra, Rajib Kumar

doi:10.1021/jp4091816

Cited by 25 publications

(45 citation statements)

References 45 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The large negative value of enthalpy shows that the migration of PIP to SAIL micelle involved the disruption of water structure at micellar surface which provides a more hydrophobic environment to PIP than its previous state. 3,32 This result is in good agreement with our spectroscopic results. The binding of PIP with ctDNA was also governed through the exothermic process (Δ H 0 = −71.80 kcal mol –1 ) with a large negative entropy contribution ( T Δ S 0 = −64.96 kcal mol –1 ).…”

Section: Resultssupporting

confidence: 92%

“…A similar observation was previously reported in cases of PSF and SDS systems. 3 The overall absorption and emission spectroscopy result suggested that the microenvironment around the fluorophore molecule is different when compared to its native environment, and PIP is introduced to the micellar region of SAIL. The emission spectral change of PIP in the presence of SAIL was further utilized to determine the penetration of PIP in the SAIL micelle.…”

Section: Resultsmentioning

confidence: 99%

“…On this prospect from the last few years, researchers are focused on the deintercalation processes through different carriers. 3−5…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System

Maurya¹,

Parray²,

Maurya³

et al. 2019

ACS Omega

View full text Add to dashboard Cite

Biocompatible surface-active ionic liquid (SAIL) was used first to study the deintercalation process of a well-known natural compound piperine (PIP) as an anticancer drug, obtained from PIP–calf thymus DNA (ctDNA) complex under controlled experimental conditions. In this study, we have been exploring the interaction of PIP in SAIL (1-butyl-3-methylimidazolium octyl sulfate ionic liquid ([C4mim][C8OSO3])), ctDNA, and deintercalation of PIP from the PIP–ctDNA complex through SAIL micelle using various spectroscopic techniques. Absorption, emission, and lifetime decay measurements provide strong evidence of the relocation of PIP molecules from ctDNA to SAIL micelle. Fluorescence quenching and steady-state fluorescence anisotropy were employed to examine the exact location of PIP in different media. Moreover, the surface tension technique was also employed to confirm the release of PIP molecules from the PIP–ctDNA complex in the presence of SAIL. Circular dichroism analysis suggested that SAIL micelle does not perturb the ctDNA structure, which supported the fact that SAIL micelle can be used as a safe vehicle for PIP. Overall, the study highlighted a novel strategy for deintercalation of drug using SAIL because the release of the drug can be controlled over a period by varying the concentration and composition of the SAIL.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System

Maurya¹,

Parray²,

Maurya³

et al. 2019

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Absorption and circular dichroism spectroscopy, and thermal denaturation studies have shown that the presence of SDS micelles induces the exclusion of intercalated mitoxantrone monomer from DNA and further their encapsulation in micelles [69]. This deintercalation process of intercalated drug molecules from DNA in the presence of surfactant micelles and their transfer inside of micelles was observed for different ligands [71,72,73,74,75,76]. Considering that amphiphilic molecules are present in real biological systems (i.e., phospholipids in the cell membranes, polyamines in nucleus, bile salts in the bile), this deintercalation process induced by micelles may have significant importance in biological processes [71].…”

Section: Uv-vis Absorption Studiesmentioning

confidence: 99%

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

2016

View full text Add to dashboard Cite

Abstract:Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed.

show abstract

“…Patra et al also reported that SDS micelles do not give the structure effect on ctDNA. 56 This result supported that we can use SDS micellar systems as the carrier of drugs for their safe delivery to the target, DNA.…”

Section: Resultsmentioning

confidence: 57%

Probing the Intercalation of Noscapine from Sodium Dodecyl Sulfate Micelles to Calf Thymus Deoxyribose Nucleic Acid: A Mechanistic Approach

2019

View full text Add to dashboard Cite

Noscapine (NOS) is efficient in inhibiting cellular proliferation and induces apoptosis in nonsmall cell, lung, breast, lymphatic, and prostate cancers. The micelle-assisted drug delivery is a well-known phenomenon; however, the proper mechanism is still unclear. Therefore, in the present study, we have shown a mechanistic approach for the delivery of NOS from sodium dodecyl sulfate (SDS) micelles to calf thymus deoxyribose nucleic acid (ctDNA) base-pairs using various spectroscopic techniques. The absorption and emission spectroscopy results revealed that NOS interacts with the SDS micelle and resides in its hydrophobic core. Further, the intercalation of NOS from SDS micelles to ctDNA was also shown by these techniques. The anisotropy and quenching results further confirmed the relocation of NOS from SDS micelles to ctDNA. The CD analysis suggested that SDS micelles do not perturb the structure of ctDNA, which supported that SDS micelles can be used as a safe delivery vehicle for NOS. This work may be helpful for the invention of advanced micelle-based vehicles for the delivery of an anticancer drug to their specific target site.

show abstract

Entropy Contribution toward Micelle-Driven Deintercalation of Drug–DNA Complex

Cited by 25 publications

References 45 publications

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

Probing the Intercalation of Noscapine from Sodium Dodecyl Sulfate Micelles to Calf Thymus Deoxyribose Nucleic Acid: A Mechanistic Approach

Contact Info

Product

Resources

About