Enterosorbents in the comprehensive therapy for acute intestinal infections in adults

Abstract

Objective. To evaluate the efficacy and tolerability of the dietary supplement ‘Complex with pectin Liquid Charcoal’ used for the treatment of acute intestinal infections (AIIs) in adults. Patients and methods. This study included 40 patients aged between 18 and 59 years diagnosed with AIIs of unknown etiology (moderate gastroenteritis) and treated in the Republican Clinical Hospital for Infectious Diseases in Kazan in 2019. Participants were divided into two groups according to their treatment scheme. Patients in the experimental group (n = 20) received dietary supplement “Complex with pectin Liquid Charcoal” as a part of their basic therapy (1 sachet × 3 times a day 1 hour before meals), while patients in the control group received activated charcoal at a dose of 0.1 g/kg/day divided into 3 portions. Data analysis was performed using the Microsoft Office Excel 2007 and STATISTICA 10.0 software and included Student t-test. Results. In patients receiving “Complex with pectin Liquid Charcoal”, intoxication syndrome was 1.5 days (31.3%) shorter than that in patients receiving activated charcoal (р < 0.001). Moreover, the duration of gastroenteritis syndrome among patients from the experimental group was 0.5 days (15.4%) shorter than that in the controls (р < 0.05). “Complex with pectin Liquid Charcoal” ensured a 28% shortening of total disease duration compared to the control group (3.6 ± 0.16 days vs 5.0 ± 0.17 days) (р < 0.001). Conclusion. Our findings suggest high clinical efficacy of the dietary supplement “Complex with pectin Liquid Charcoal” in the treatment of AIIs in adults. The supplement has also shown good safety profile and ensured high patient compliance. Key words: dietary supplement “Complex with pectin Liquid Charcoal”, acute intestinal infection, pectin, sorbents