Enteropathogenic Escherichia coli prevalence in laboratory rabbits

Swennes, Alton G.; Buckley, Ellen M.; Madden, Carolyn M.; Byrd, Charles P.; Donocoff, Rachel S.; Rodriguez, Loretta; Parry, N.; Fox, James G.

doi:10.1016/j.vetmic.2013.01.006

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…10.1) (Garcia et al, 2002). Laboratory rabbits can be reservoir hosts of pathogenic E. coli without exhibiting clinical signs (García and Fox, 2003;Swennes et al, 2013). Laboratory rabbits can be reservoir hosts of pathogenic E. coli without exhibiting clinical signs (García and Fox, 2003;Swennes et al, 2013).…”

Section: A Epec and Stecmentioning

confidence: 99%

“…Epizootiology EPEC and EHEC can be enzootic in rabbit colonies and these bacteria are transmitted by the fecal-oral route (García and Fox, 2003;Swennes et al, 2013;Swennes et al, 2012). EPEC and EHEC coinfections are possible (García and Fox, 2003;Garcia et al, 2002).…”

Section: A Epec and Stecmentioning

confidence: 99%

“…EPEC and EHEC present a zoonotic risk (Garcia et al, 2010;Poeta et al, 2010;Swennes et al, 2013). EPEC and EHEC present a zoonotic risk (Garcia et al, 2010;Poeta et al, 2010;Swennes et al, 2013).…”

Section: A Epec and Stecmentioning

confidence: 99%

See 2 more Smart Citations

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

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Section: A Epec and Stecmentioning

confidence: 99%

Section: A Epec and Stecmentioning

confidence: 99%

See 1 more Smart Citation

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

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“…Several bacterial diseases afflict the rabbit breeding industry, including pathogenic Escherichia coli ( E. coli ) infection and rabbit Clostridium perfringens disease (13, 14). Treatment for the diseases cannot involve the use of long-term antibiotics due to their negative effects.…”

Section: Introductionmentioning

confidence: 99%

Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits

et al. 2017

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Probiotics such as Lactobacillus and Bifidobacterium have been successfully used to promote growth and prevent diseases. Previous reports have demonstrated that Bacillus subtilis (B. subtilis) was a potential probiotic for animals. In this research, 180 B. subtilis were isolated from the soil, identified, and investigated in vitro. Furthermore, five B. subtilis were selected and mixed to investigate their effect on growth performance, immune response, intestine microbiota, and disease resistance in rabbits. Rabbits with a diet of 106 CFU g−1 mixed B. subtilis exhibited the best growth performance and higher serum IgG and IgA than controls (P < 0.05). Moreover, dairy with B. subtilis can promote the balance of intestinal flora. The major proinflammatory factor and β-defensin were upregulated compared with the controls. After 7 weeks of feeding, the survival rate of the rabbits fed with B. subtilis was significantly higher than those in the control groups postinfected with Escherichia coli. At the same time, this study detected higher expression of β-defensin and reduced bacteria contents of the heart and cecal contents from the diet mixed with B. subtilis compared with the control groups. In conclusion, dietary supplementation with B. subtilis for rabbits could improve growth performance, intestinal homeostasis, and immune organ index and enhance innate immune response as well as disease resistance. These findings showed that the induction of β-defensin by B. subtilis might be an interesting new therapeutic strategy to strengthen innate defense mechanisms.

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“…Fecal cultures were negative for common bacterial pathogens including Salmonella spp., Shigella spp., Yersinia spp., Campylobacter spp., and Helicobacter spp.. Enteropathogenic Escherichia coli (EPEC), serotype O-:H2, was identified based on isolation and an intimin Gene ( eae )-positive shiga-like toxin-negative PCR profile ( E. coli Reference Center, Penn State College of Agricultural Sciences, University Park, PA). 4 This infection was treated with enrofloxacin (5 mg/kg PO BID) and later with metronidazole (15 mg/kg PO BID) as diarrhea persisted. This episode of diarrhea did resolve with metronidazole treatment, although the monkey continued to have diarrhea during future clinical thrombopathy episodes.…”

Section: Case Presentationmentioning

confidence: 99%

Adult‐onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge

Frydman

Pate

Marini

et al. 2017

Veterinary Clinical Pathol

Self Cite

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An 8-year old, male Rhesus macaque (Macaca mulatta) previously used for dengue virus vaccine research with viral challenge, presented with adult-onset, chronic, cyclic thrombocytopenia. Platelet number, morphology and function were evaluated by automated hematology, peripheral blood smears, electron microscopy, flow cytometry, and impedance aggregometry. Bone marrow was evaluated by cytology. Both, serum anti-dengue non-structural protein 1 (NS1) antibodies and anti-platelet antibodies were detected by ELISA. Platelet characterization showed a lack of aggregation to all agonists (ADP, ASP, and collagen), increased activation with increased expression of surface marker (HLA-ABC), and an absence of surface receptor GPIX during clinical episodes of petechiae and ecchymoses, even in the presence of normal platelet counts. Bone marrow aspirates identified potential mild megakaryocytic hypoplasia. All platelet functions and morphologic attributes were within normal limits during clinically normal phases. Presence of anti-dengue NS1 serum antibodies confirmed a positive dengue virus titer 8 years post-vaccination. Based on the history and clinical findings, a primary differential diagnosis for this chronic, cyclic platelet pathology was autoimmune platelet destruction with potential bone marrow involvement.

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Enteropathogenic Escherichia coli prevalence in laboratory rabbits

Cited by 16 publications

References 29 publications

Biology and Diseases of Rabbits

Biology and Diseases of Rabbits

Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits

Adult‐onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge

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