Enterococcus faecalis as multidrug resistance strains in clinical isolates in Imam Reza Hospital in Kermanshah, Iran

Mohammadi, F.; Ghafourian, Sobhan; Mohebi, Reza; Taherikalani, Morovat; Pakzad, Iraj; Valadbeigi, Hasan; Hatami, Vahid; Sadeghifard, Nourkhoda

doi:10.1080/09674845.2015.11665750

Cited by 10 publications

(9 citation statements)

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“…In our study, E. faecalis isolates were obtained from various clinical specimens. Similar to other reports from Iran, noticeable resistance to several antimicrobial agents among E. faecalis strains was observed [416]. Nearly half of the isolates were resistant to vancomycin (45.1%).…”

Section: Discussionsupporting

confidence: 88%

High Incidence of Virulence Factors Among ClinicalEnterococcus faecalisIsolates in Southwestern Iran

et al. 2017

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BackgroundOver the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E. faecalis strains isolated from hospitalized patients in Shiraz, south west of Iran.Materials and MethodsA total of 51 E. faecalis isolates from the urine, blood, pleural fluid, peritoneal fluid, eye discharge, endotracheal tube (ETT) and transjugular intrahepatic portosystemic shunt (TIPS) specimens of patients were identified by phenotypic and genotypic methods. Antimicrobial sensitivity tests and detection of virulence factors were performed using standard methods.ResultsThe efa and asa1 were the most frequently detected gene (100%) among the isolates, followed by esp (94.1%), ace (90.2%), gelE (80.4%), cylA (64.7%), and hyl (51%). More than half of the isolates (52.9%) were high level gentamicin resistant (HLGR). Vancomycin resistance was observed among 23 (45.1%) isolates. The lowest antimicrobial activity was related to erythromycin (3.9%), tetracycline (5.9%) and ciprofloxacin (9.8%). No isolate was found resistant to fosfomycin and linezolid.ConclusionOur data indicated a high incidence of virulence factors among E. faecalis strains isolated from clinical samples. Colonization of drug resistant virulent isolates in hospital environment may lead to life threatening infection in hospitalized patients. Therefore, infection control procedures should be performed.

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Section: Discussionsupporting

confidence: 88%

High Incidence of Virulence Factors Among ClinicalEnterococcus faecalisIsolates in Southwestern Iran

et al. 2017

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“…During the initial database search, a total of 150 articles were found. After exclusion of the articles according to our criteria, a total of 44 articles were included in the analysis [3] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] . Among these 44 articles, 24 were associated with general patients (3071 isolates), 12 studies assessed their enterococcal populations on the basis of species (3906 isolates) and eight investigated colonization of enterococci among complicated patients with specific underlying conditions (589 isolates).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, no significant difference was seen where different methodologies were used. For example, a low mean rate of resistance was deduced for gentamycin during 2008 (7%), 2009 (6%) and 2014 (7%) [3] , [35] , [41] , [45] .…”

Section: Discussionmentioning

confidence: 99%

Rise of antibiotic resistance in clinical enterococcal isolates during 2001–2016 in Iran: a review

Asadollahi

Razavi

Asadollahi

et al. 2018

New Microbes and New Infections

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IntroductionThe clinical significance of enterococci is mostly related to its antibiotic resistance which contributes to colonization and infection, in particular amongst the hospitalized patients. The present review has examined the literature to provide a comprehensive data on enterococci antibiotic resistance during the last 20 years in Iran.MethodsSearch engines such as Google Scholar and PubMed were used to identify all Persian and English-language articles investigating enterococci in Iran from 1996 to 2017. The search terms were “enterococci”, “enterococcal”, “enterococcus”, “Iran”, “bacterial resistance”, “antibiotic resistance” and “resistance”.ResultsDecrease in the resistance trend against ampicillin, gentamycin and ciprofloxacin was observed over a period of 15 years (2001 to 2016) in Iran. During a 10 years period from 2001 to 2015, the rate of resistance among Enterococcus faecalis species was less than Enterococcus faecium. The resistancerate, however, was considerably increased for both species during this period. The mean resistance rates for vancomycin, gentamicin, ciprofloxacin, erythromycin, nitrofurantoin, chloramphenicol, trimethoprim-sulfametoxazol, imipenem and teicoplanin were higher among complicated cases (patients with underlying debilitating disorders) compared to general cases (hospitalized or outpatients with no specific underlying disorder).ConclusionsE. faecalis and E. faecium showed a rise in the mean resistance against all the antibiotics during a 10-year period from 2010 to 2015. With the exception of penicillin and ampicillin, resistance to all antibiotics was higher amongst complicated cases compared to general patients.

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“…Antibiotic resistance continues to be a major international problem in clinical microbiology, as reflected by the high frequency of scientific research into this topic [38][39][40][41][42][43][44][45]. Although group B Streptococcus species are widely believed to be sensitive to penicillin, a screening method for the possibility of reduced sensitivity (i.e., resistance) has been developed [46].…”

Section: Microbiologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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Enterococcus faecalis as multidrug resistance strains in clinical isolates in Imam Reza Hospital in Kermanshah, Iran

Cited by 10 publications

References 0 publications

High Incidence of Virulence Factors Among ClinicalEnterococcus faecalisIsolates in Southwestern Iran

High Incidence of Virulence Factors Among ClinicalEnterococcus faecalisIsolates in Southwestern Iran

Rise of antibiotic resistance in clinical enterococcal isolates during 2001–2016 in Iran: a review

British Journal of Biomedical Science in 2016. What have we learned?

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