Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?

Yeo, Chia Rou; Sanghvi, Kaushal; Yeo, Danson

doi:10.1016/s2468-1253(20)30048-0

Cited by 777 publications

(803 citation statements)

References 14 publications

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“…present with diarrhoea, and SARS-CoV-2 RNA has been detected in stool and blood samples. 11 This evidence implicates the possibility of viral exposure in the liver. Both SARS-CoV-2 and SARS-CoV bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter the target cell, 7 where the virus replicates and subsequently infects other cells in the upper respiratory tract and lung tissue; patients then begin to have clinical symptoms and manifestations.…”

Section: Liver Injury In Covid-19: Management and Challengesmentioning

confidence: 78%

Liver injury in COVID-19: management and challenges

Zhang¹,

Shi²,

Wang³

2020

The Lancet Gastroenterology & Hepatology

1,691

1,842

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Section: Liver Injury In Covid-19: Management and Challengesmentioning

confidence: 78%

Liver injury in COVID-19: management and challenges

Zhang¹,

Shi²,

Wang³

2020

The Lancet Gastroenterology & Hepatology

1,691

1,842

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“…The virus RNA in pharyngeal test was negative, but it was positive in feces [13]. Molecular binding and clinical cases indicate the affinity between the virus and gastrointestinal tract, which also provides the possibility for the fecal oral transmission of the virus [14].…”

Section: Discussionmentioning

confidence: 99%

A case of COVID-19 patient with the diarrhea as initial symptom and literature review

Yang

Zhao

Qiang

et al. 2020

Clinics and Research in Hepatology and Gastroenterology

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KEYWORDS Diarrhea; Novel coronavirusSummary Since Dec 2019, a cluster of pneumonia outbreak in Wuhan, Hubei province, China, and soon spread to all province of China. The pathogen was proved to be a novel betacoronavirus called 2019 novel coronavirus (officially named by the World Health Organization as COVID-19). The typical clinical manifestations were fever, cough, dyspnea, and myalgia or fatigue. Less common symptoms included headache, diarrhea, nausea and vomiting. However diarrhea as the first symptom is rarely reported. Here we reported a case of 2019 novel coronavirus-infected patient (NCIP) with diarrhea as the initial symptom. Image of CT scan and laboratory examination and careful collected as well as detection of viral RNA in pharynx. The case demonstrate that gastrointestinal symptoms ware not rare in NCIP, and diarrhea could be the initial symptom.

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“…after toilet use. Although viral RNA has been found in the stool, no oro-fecal transmission has yet been documented [9,10].…”

Section: Transmission/contagiousnessmentioning

confidence: 99%

COVID-19 and ENT Pediatric otolaryngology during the COVID-19 pandemic. Guidelines of the French Association of Pediatric Otorhinolaryngology (AFOP) and French Society of Otorhinolaryngology (SFORL)

Leboulanger

Sagardoy

Akkari

et al. 2020

European Annals of Otorhinolaryngology, Head and Neck Diseases

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Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?

Cited by 777 publications

References 14 publications

Liver injury in COVID-19: management and challenges

Liver injury in COVID-19: management and challenges

A case of COVID-19 patient with the diarrhea as initial symptom and literature review

COVID-19 and ENT Pediatric otolaryngology during the COVID-19 pandemic. Guidelines of the French Association of Pediatric Otorhinolaryngology (AFOP) and French Society of Otorhinolaryngology (SFORL)

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