Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Kimble, Roy M.; Breier, Bernhard H.; Gluckman, P. D.; Harding, Jane E.

doi:10.1677/joe.0.1620227

Cited by 52 publications

(37 citation statements)

References 54 publications

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“…As a primary regulator of fetal IGF-I, the fall in fetal insulin levels may explain the reduction in plasma IGF-I in undernourished fetuses on day 135 (Fowden 1995). IGF-I is also critical to fetal growth and anabolism, influencing gut (Kimble et al 1999), renal (Hammerman & Miller 1993) and pancreatic cell development (Hugl et al 1998) as well as cardiac growth and function (Isgaard et al 1999). The decline of fetal glucose, insulin and IGF-I may thus contribute to nutritionally mediated changes in fetal growth.…”

Section: Discussionmentioning

confidence: 99%

The effect of maternal undernutrition on ovine fetal growth

Osgerby

Wathes

Howard³

et al. 2002

Journal of Endocrinology

157

104

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Modifications in maternal nutrition during pregnancy can significantly disrupt fetal growth and subsequent post-natal health and survival. This study investigated the effects of undernutrition on fetal growth and the potential mechanisms involved. Tissue from pregnant ewes (n=27) was investigated on days 45, 90 and 135 of gestation (term=150 days). The thoracic girth (P<0·05) was greater in fetuses from nutrient restricted ewes on day 45 and there was also a trend towards an increased gut weight (P<0·08). By day 90, the fetal brain and thymus weight were lighter in underfed than in well-fed animals whilst the weight of the fetal ovaries was heavier (P<0·05). On day 135 the fetal heart, pancreas, thymus, gut and kidney weights were lighter in undernourished ewes (P<0·05). When expressed as a percentage of fetal body weight, significance was retained in the heart, pancreas and thymus (P<0·05). Bone growth was also affected. At day 90 the fetal femur and metatarsal were longer in underfed mothers (P<0·05). In contrast, the fetal humerus and scapula were shorter in underfed than in well-fed animals on day 135 (P<0·05) when the weight of the semitendinosus muscle (P<0·05) was also reduced. The fall in fetal glucose (P<0·1), insulin (P<0·01) and IGF-I (P<0·01) levels in underfed ewes on day 135 may have compromised fetal growth. Fetal plasma IGF binding protein-2 also increased between days 90 and 135 in underfed ewes (P<0·03), whilst levels were unaltered in well-fed animals. Although maternal and fetal plasma IGF-I levels increased with gestation (P<0·01) and the placentome morphology altered in all ewes (P<0·05), the fall in placental mass (P<0·05), amniotic and allantoic glucose concentrations (P<0·05) and maternal plasma glucose and insulin levels (P<0·05) in underfed ewes in late gestation may have compromised fetal substrate delivery. These perturbations in fetal development may have significant implications on adult health and carcass conformation, raising important health and economic issues in medical and agricultural sectors.

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Section: Discussionmentioning

confidence: 99%

The effect of maternal undernutrition on ovine fetal growth

Osgerby

Wathes

Howard³

et al. 2002

Journal of Endocrinology

157

104

View full text Add to dashboard Cite

show abstract

“…When infused into the esophagus of fetal sheep, IGF-I improves somatic growth, spleen weight, and bowel wall thickness compared to control. 22 A single injection of labeled IGF-I into ovine AF demonstrated sustained delivery of IGF-I from the AF to the fetal gut and then into the systemic circulation over a 7-day period. 23 IGF-I and IGF-II receptors, as well as insulin receptors, are found throughout the human neonatal gut.…”

Section: Nutritive Functions Of Afmentioning

confidence: 95%

Amniotic Fluid: Not Just Fetal Urine Anymore

2005

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“…However, significant differences of B max were not seen at all intestinal sites, indicating that the regulation was site-specific. The fact that for IGF-IR the only significant differences in B max between pre-term and full-term newborn calves were seen in the colon was surprising because IGF-I is a ubiquitous growth factor, as shown in calves (Cordano et al 1998) and has widespread effects (Kimble et al 1999).…”

Section: Igf-ir Igf-iir and Ir Concentrations At The Mrna And Proteimentioning

confidence: 97%

Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves

Georgiev¹,

Georgieva²,

Pfaffl³

et al. 2003

Journal of Endocrinology

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Intestinal development is modified by age and nutrition, mediated in part by insulin-like growth factors (IGF-I, IGF-II) and insulin. We have investigated whether expression of IGF-I, IGF-II and insulin receptors (IGF-IR, IGF-IIR and IR; measured by real-time RT-PCR) and binding capacity (B max ) of IGF-IR, IGF-IIR and IR in the mucosa of the small and large intestine of neonatal calves are modified by age and different feeding regimes.In experiment 1, pre-term (GrP) and full-term (GrN) calves (after 277 and 290 days of pregnancy respectively) were killed immediately after birth before being fed; a further group of full-term calves were fed for 7 days and killed on day 8 of life (GrC 1-3 ). In experiment 2, full-term calves were killed on day 8 after being fed first-colostrum for 7 days (GrC max

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Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Cited by 52 publications

References 54 publications

The effect of maternal undernutrition on ovine fetal growth

The effect of maternal undernutrition on ovine fetal growth

Amniotic Fluid: Not Just Fetal Urine Anymore

Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves

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