Enteral Feeding Therapy for Newly Diagnosed Pediatric Crohnʼs Disease: A Double-Blind Randomized Controlled Trial with Two Years Follow-Up§

Grogan, Joanne; Casson, David; Terry, A.; Burdge, Graham C.; El‐Matary, Wael; Dalzell, A M

doi:10.1002/ibd.21690

Cited by 77 publications

(81 citation statements)

References 24 publications

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“…The most popular theory was that elemental diets had a reduced antigenic load to the inflamed bowel compared with full protein feeds [O'Sullivan and O'Morain, 1998]. However, this may not be the case because polymeric feeds have since been found to be equally efficacious [Zachos et al 2007;Grogan et al 2012]. In addition, because polymeric feeds are more palatable than elemental feeds, the former tend to be used first line.…”

Section: Induction Of Remission: Enteral Nutritionmentioning

confidence: 99%

Nutritional management of Crohn’s disease

Donnellan

Lee

Lal

2013

Therap Adv Gastroenterol

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Nutritional care and therapy forms an integral part of the management of patients with Crohn's disease (CD). Nutritional deficiencies result from reduced oral intake, malabsorption, medication side effects and systemic inflammation due to active disease. Enteral nutrition has a role in support for the malnourished patient, as well as in primary therapy to induce and maintain remission. The use of parenteral nutrition in CD is mainly limited to the preoperative setting or for patients with intestinal failure, but does not offer any additional advantage over EN in disease control. Dietary modifications, including eliminationreintroduction diets and a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet may improve symptoms but there are currently no data to suggest that these approaches have any role in the induction or maintenance of remission.

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Section: Induction Of Remission: Enteral Nutritionmentioning

confidence: 99%

Nutritional management of Crohn’s disease

Donnellan

Lee

Lal

2013

Therap Adv Gastroenterol

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“…Clinical trials comparing EEN to steroids based on remission rates as outcome parameter showed an overall remission rate of approximately 75% for EEN at the end of exclusive treatment. Remission rates with steroids were not different from EEN-induced remission in these two meta-analyses based on a total of 11 pediatric clinical trials [32][33][34][35][36][37][38][39][40][41] . A further pediatric study has recently been published [41] , showing data in line with the previous studies.…”

Section: Efficacy Of Een As Treatment Option For CDmentioning

confidence: 99%

Role of Diet in Inflammatory Bowel Disease

Ruemmele¹

2016

Ann Nutr Metab

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The incidence of inflammatory bowel disease (IBD) is steadily in the rise in Western as well as in developing countries paralleling the increase of westernized diets, characterized by high protein and fat as well as excessive sugar intake, with less vegetables and fiber. An interesting hypothesis is that environmental (food-) triggered changes of the intestinal microbiome might cause a proinflammatory state preceding the development of IBD. Indeed, an intact intestinal epithelial barrier assuring a normal bacterial clearance of the intestinal surface is crucial to guarantee intestinal homeostasis. Any factors affecting the epithelial barrier function directly or indirectly may impact on this homeostasis, as well as any changes of the intestinal microbial composition. It is intriguing to learn that some frequently used food components impact on the quality of the intestinal barrier, as well as on the composition of the intestinal microbiome. This highlights the close interaction between living conditions, hygiene, food habits and food quality with the bacterial composition of the intestinal microbiome and the activation status of the intestinal immune system. There is clear evidence that nutritional therapy is highly successful in the treatment of Crohn's disease (CD). Exclusive enteral nutrition is well established as induction therapy of CD. New diets, such as a CD exclusion diet or defined diets (specific carbohydrate diets, FODMAP diet, Paleolithic diet) are being discussed as treatment options for IBD. Well-designed clinical trials in IBD are urgently required to define the precise role of each of these diets in the prevention or management of IBD. Up to now, the role of diet in IBD is highly undermined by lay and anecdotal reports without sufficient scientific proof.

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“…em DC ativa 35,36 . Em ambos, ω3 foi incluído na fórmula enteral para ser usado como suplemento ou nutrição enteral total.…”

Section: Dois Estudos Foram Identificados Sobre O Efeito Do ω3unclassified

“…Não foi realizada avaliação endoscópica do efeito da terapia. O segundo experimento foi conduzido em pacientes pediátricos 36 . O estudo comparou duas fórmulas enterais como tratamento primário para DC ativa sem nenhuma outra terapia.…”

Section: Dois Estudos Foram Identificados Sobre O Efeito Do ω3unclassified

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Efeitos do ômega-3 nas doenças inflamatórias intestinais: uma revisão da literatura

Cecconello

Marques

2014

Cienc. Saude

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RESUMOIntrodução: Os ácidos graxos poliinsaturados omega-3 (ω-3) tem vários efeitos benéficos para a saúde humana. Dentre estas, possui ação antiinflamatória, diminuindo a síntese de derivados do ácido araquidônico (AA). Assim, supõe-se que a suplementação de óleo de peixe contendo ácido eicosapentaenóico (EPA) e ácido docosahexaenóico (DHA) poderia atenuar os efeitos de processos inflamatórios, diminuindo a síntese de eicosanóides precursores da inflamação, bem como o uso de medicamentos antiinflamatórios. Objetivo: O objetivo deste artigo foi descrever os principais efeitos da terapêutica nutricional baseada na utilização da suplementação de ω3 em pacientes com doenças inflamatórias intestinais (DII) através de uma revisão da literatura. Materiais e Métodos: Trata-se de uma revisão da literatura realizada em revistas indexadas nas bases de dados Medline, Lilacs, Scielo e Pubmed, nos idiomas português, inglês e espanhol, que abrangeu artigos publicados entre 1989 e 2014. Resultados: De 179 referências relativas às doenças inflamatórias intestinais analisadas, após a aplicação dos critérios de inclusão e exclusão, 18 artigos foram selecionados entre estudos clínicos randomizados, observacionais, epidemiológicos, estudos de coorte e caso-controle em humanos. Conclusão: A dose de ω3 utilizada nestes ensaios foi em média 4,5g/dia. EPA e DHA são incorporados no tecido da mucosa intestinal de pacientes com DII que complementam a alimentação com óleo de peixe e isto resulta em efeitos anti-inflamatórios com a melhora no resultado clínico, na histologia da mucosa intestinal, nos resultados da sigmoidoscopia, bem como, menor índice de recidiva e diminuição do uso de corticosteróides.Palavras-chave: doenças inflamatórias intestinais; doença de Crohn; proctocolite; ácidos graxos ômega-3. ________________________________________________________________________________________________ Medline, Lilacs, Scielo and Pubmed databases, in Portuguese, English and Spanish, and ABSTRACT Introduction: Polyunsaturated omega-3 (ω3) fatty acids have many beneficial effects on human health. Among these, it has anti-inflammatory effect, decreasing the synthesis of derivatives of the arachidonic acid (AA). Therefore, it is believed that the supplementation of fish oil containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could reduce the effects of inflammatory processes by decreasing the synthesis of eicosanoid precursors of inflammation, as well as the use of anti-inflammatory drugs. Objective: The purpose of this paper was to describe the effects of therapy based on nutritional supplementation of omega-3 in patients with inflammatory bowel disease (IBD) in a literature review. Materials and Methods: This is a review of the literature made in journals indexed in

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Enteral Feeding Therapy for Newly Diagnosed Pediatric Crohnʼs Disease: A Double-Blind Randomized Controlled Trial with Two Years Follow-Up§

Abstract: There was no significant difference between EF and PF in inducing remission. One-third of children maintained remission. Changes in plasma polyunsaturated fatty acid status were subtle and may be relevant; however, further evaluation is recommended.

Cited by 77 publications

References 24 publications

Nutritional management of Crohn’s disease

Nutritional management of Crohn’s disease

Role of Diet in Inflammatory Bowel Disease

Efeitos do ômega-3 nas doenças inflamatórias intestinais: uma revisão da literatura

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