Entanglement of Sepsis, Chronic Kidney Disease, and Other Comorbidities in Patients Who Develop Acute Kidney Injury

Heung, Michael; Koyner, Jay L.

doi:10.1016/j.semnephrol.2015.01.004

Cited by 15 publications

(10 citation statements)

References 160 publications

(173 reference statements)

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“…As many as 20% of critically ill patient have irreversible renal damage due to acute cortical necrosis and another 40% have incomplete renal recovery, leading to CKD ( 44 ). It is not uncommon to observe that episodes of bacterial sepsis accelerate the rate of progression of pre-existing CKD by multiple mechanisms ( 45 ).…”

Section: Viral Infectionsmentioning

confidence: 99%

Infection-Induced Kidney Diseases

Prasad

Patel

2018

Front. Med.

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Infection induced kidney diseases are of concern for clinicians because timely detection and treatment of infections may cure or limit the extent of injury inflicted by microorganisms causing the infections. Infections can cause kidney injury by either direct invasion, or indirectly by immune mediated mechanisms, which manifest as post-infectious glomerulonephritis, or infection-related glomerulonephritis. Clinical manifestations may be acute or chronic depending on the microorganisms, endemic/epidemic nature and source of infection. All microbials virus, bacteria, mycobacteria, fungus, and protozoa have been implicated in kidney diseases either causing direct kidney injuries or immune-mediated injuries. Infection control practices in large parts of world is limited by poverty, social behavior, high population density, deforestation, inadequate access to safe drinking water, and poor health care facilities. Although, antimicrobials and vaccinations have successfully eradicated and cured many infectious diseases; however injudicious antimicrobial use and emergence of resistant organisms complicated the disease severity like secondary renal amyloidosis with chronic persistent infection. Re-emergence of various infections has been a recent pattern in developed world leading to uncertain diagnostic challenges, and association with kidney diseases.

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Section: Viral Infectionsmentioning

confidence: 99%

Infection-Induced Kidney Diseases

Prasad

Patel

2018

Front. Med.

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“… Note: Data from Heung and Koyner48 and Leelahavanichkul et al49 Abbreviations: AKI, acute kidney injury; ARDS, acute respiratory distress syndrome; CKD, chronic kidney disease; HIV, human immunodeficiency virus; Post-op, post-operative.…”

Section: Figurementioning

confidence: 99%

Update on sepsis-associated acute kidney injury: emerging targeted therapies

Doyle¹,

Forni²

2016

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Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies.

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“…Cancer patients are particularly at risk for AKI secondary to infection and sepsis [ 5 , 6 ], tumor lysis syndrome (TLS) [ 7 ], kidney damage induced by immunosuppression after hematopoietic stem cell transplantation (HSCT) [ 8 ], and direct effects from the primary malignancy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury in critically ill cancer patients: an update

et al. 2016

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Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients frequently develop acute kidney injury (AKI). A wide variety of definitions for AKI are still used in the cancer literature, despite existing guidelines on definitions and staging of AKI. Alternative diagnostic investigations such as Cystatin C and urinary biomarkers are discussed briefly. This review summarizes the literature between 2010 and 2015 on epidemiology and prognosis of AKI in this population. Overall, the causes of AKI in the setting of malignancy are similar to those in other clinical settings, including preexisting chronic kidney disease. In addition, nephrotoxicity induced by the anticancer treatments including the more recently introduced targeted therapies is increasingly observed. However, data are sometimes difficult to interpret because they are often presented from the oncological rather than from the nephrological point of view. Because the development of the acute tumor lysis syndrome is one of the major causes of AKI in patients with a high tumor burden or a high cell turnover, the diagnosis, risk factors, and preventive measures of the syndrome will be discussed. Finally, we will briefly discuss renal replacement therapy modalities and the emergence of chronic kidney disease in the growing subgroup of critically ill post-AKI survivors.

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Entanglement of Sepsis, Chronic Kidney Disease, and Other Comorbidities in Patients Who Develop Acute Kidney Injury

Cited by 15 publications

References 160 publications

Infection-Induced Kidney Diseases

Infection-Induced Kidney Diseases

Update on sepsis-associated acute kidney injury: emerging targeted therapies

Acute kidney injury in critically ill cancer patients: an update

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