Ensuring of Reliability of Metrological Characteristics of the Conductometric Systems With Differetial Sensors

Мельник, В. Г.; Дзядевич, С. В.; Novik, A. I.; Погребняк, В. Д.; Сліцький, О. В.; Лепіх, Я. І.; Lienkov, Serhii; Protsenko, Vladyslav

doi:10.18524/1815-7459.2011.4.119304

Cited by 3 publications

(4 citation statements)

References 1 publication

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“…A research, which we have done over the past few years, has allowed us to create a technical basis for a radical increase in CMRR of differential conductometric channels with non-identical sensors [32][33][34][35]. A comprehensive analysis of measurement processes in the previously developed differential conductometric circuits [14] allowed us to develop a measurement method with quasi-equilibrium of the bridge circuit, which theoretically allows eliminating in great degree the above error [32]. Its essence lies in bringing the bridge circuit with non-identical conductometric transducers to a state with a calculated deviation from complete equilibrium before adding the analyte to the buffer solution in the measurement cell.…”

Section: Bridge Circuit and Measurement Methodmentioning

confidence: 99%

“…The causes and methods for overcoming the individual parts of this problem we studied in our earlier works [14][15]. First, in [16][17][18][19], the effectiveness of a conductometric differential method in biosensors has been shown.…”

Section: Introductionmentioning

confidence: 99%

“…At large values of tanφ, their sensitivity sharply decreases. This disadvantage is significantly eliminated in the bridge circuits with the compensation of the voltage drop on C S [14]. If C S and R S of the working and reference converters are identical, CMRR of such circuits are high.…”

Section: Introductionmentioning

confidence: 99%

“…The effect of common mode interference in the differential conductometric channel does not distinguish from the response to a change in the local electrical conductivity in the active (selective) membrane of the biosensor. Thus, it is an additive error, which significantly limits the real sensitivity of the conductometric system and the reliability of the measurement results [14].…”

Section: Introductionmentioning

confidence: 99%

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Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Мельник¹,

Borshchov²,

Dzyadevych³

et al. 2021

Teh. elektrodin.

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The differential method of conductometric measurements does not fully solve the problem of the influence of changes in the background electrical conductivity of the working buffer solutions on the results of conversion of the biosensor responses. The variation in the background electrical conductivity of the buffer solution upon addition of the highly conductive analyte acts as a common mode interference and causes the additive error. Here we present a new measurement method and structure of the device for quantification of the analytes that provide a significant decrease in the measurement error associated with a change in the background electrical conductivity caused by the introduction of the analyte to the working solution prior to the generation of the informative signal. A block diagram of the device and a vector model of the balancing process of its measuring circuit are presented. The advantages of the developed method and biosensor analyzer for application within the possible changes of the transducer parameters and measurement conditions are demonstrated. References 28, figures 4.

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Section: Bridge Circuit and Measurement Methodmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Мельник¹,

Borshchov²,

Dzyadevych³

et al. 2021

Teh. elektrodin.

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Solutions for enhancement of sensitivity and metrological reliability of conductometric biosensor systems

et al. 2021

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The article presents the results of research aimed at the creation of highly sensitive, compact and inexpensive biosensor analyzers based on differential conductometry. The main factors, which reduce the sensitivity of the measuring channel and cause the measurement errors, are considered; the measurement methods to eliminate or minimize their effect are discussed. The results of theoretical and experimental studies of conductometric converters of biosensors and measuring circuits are presented. The technical realization of these methods is proposed; the important characteristics of the sensors and the developed devices are described, as well as the outcomes obtained at their approbation.

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Method of Measurement of Local Changes in Electric Conductivity of Solutions in Differential Conductometric Biosensor Systems

Мельник¹,

Borshchov²,

Dzyadevych³

et al. 2022

Praci Inst. elektrodin. Nac. akad. nauk Ukr.

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A method for measuring local changes in the electrical conductivity of solutions using differential conductometric sensors is considered. The method makes it possible to significantly reduce the measurement error due to changes in the background electrical conductivity of the measuring medium when applying the test substance with non-identical parameters of equivalent electrical circuits of the sensor components. The bridge measuring circuit is brought to a quasi-balanced state, while the voltages in the sections of the working solution of the working and reference transducers of the sensor coincide in phase with each other, and their values are proportional to the conductivity of these sections. At the same time, changes in the background electrical conductivity of the solution do not lead to a change in the imbalance signal of the bridge circuit, which allows measuring the informative local change in the electrical conductivity of the working transducer with high sensitivity. The method can be used for highly sensitive and accurate quantification of solutions of electrically conductive substances in technological processes in the energy, chemical, and food industries, in the latest technologies, in particular in biosensor analyzers. The research results of the experimental sample of the conductometric analyzer are given. Ref. 9, table.

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Ensuring of Reliability of Metrological Characteristics of the Conductometric Systems With Differetial Sensors

Cited by 3 publications

References 1 publication

Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Solutions for enhancement of sensitivity and metrological reliability of conductometric biosensor systems

Method of Measurement of Local Changes in Electric Conductivity of Solutions in Differential Conductometric Biosensor Systems

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