The South China Sea monsoon trough (SCSMT) presents remarkable year-toyear variability, which exerts great influences on the summer climate over the South China Sea and surrounding regions. The variation of SCSMT may be forced by the tropical Indo-Pacific sea surface temperature anomalies (SSTAs). The relationship between interannual variability of the SCSMT and the SSTA in tropical Indo-Pacific oceans experienced several interdecadal changes during 1958-2019, namely around the late 1970s, early 1990s, and mid-2000s, respectively. In epoch 1 (1958-1977), the significant SSTA pattern associated with the weakening of the SCSMT features the warming in the eastern tropical Indian Ocean (TIO) and the Maritime Continent (MC) which contributes to interannual variation of the SCSMT via inducing anomalous local meridional circulation. In epoch 2 (1978-1992), there is strong warming in the whole Indian Ocean basin which induces southwest-northeast vertical circulation anomalies and excites warm Kelvin wave in tropospheric atmosphere, leading to the weakening of the SCSMT. The SSTA in epoch 3 (1993-2003) features significant warming in the eastern TIO and MC which influences the SCSMT via abnormal meridional circulation and Kelvin wave, and weak cooling in the central Pacific which partly contributes to the weakening of the SCSMT via Rossby wave response. The SSTA pattern in epoch 4 (2004-2014) is similar to that in epoch 3, while the warming in the MC is weaker with insignificant meridional circulation and Kelvin-wave response, and the most significant feature is the cooling in the central to eastern Pacific (CEP) with strong Rossby wave response. These results suggest that, during different epochs, interannual variability of the SCSMT is modulated by SSTA in different key areas through different mechanisms, and the key area shifts eastward from the TIO to the CEP with time.